UCL1684 - Moligand™ , Inhibitor of K Ca2.1;Channel blocker of K Ca2.2;Inhibitor of K Ca2.2;Channel blocker of K Ca2.3;Inhibitor of K Ca2.3, CAS No.201147-18-4, Inhibitor of K Ca2.1;Channel blocker of K Ca2.2;Inhibitor of K Ca2.2;Channel blocker of K Ca2.3;Inhibitor of K Ca2.3
UCL1684 - Moligand™ , Inhibitor of K Ca2.1;Channel blocker of K Ca2.2;Inhibitor of K Ca2.2;Channel blocker of K Ca2.3;Inhibitor of K Ca2.3, CAS No.201147-18-4, Inhibitor of K Ca2.1;Channel blocker of K Ca2.2;Inhibitor of K Ca2.2;Channel blocker of K Ca2.3;Inhibitor of K Ca2.3
GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
This compound belongs to the class of organic compounds known as 4-aminoquinolines. These are organic compounds containing an amino group attached to the 4-position of a quinoline ring system.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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Application Protocols
Item-specific, manufacturer‑validated protocols
None provided in the product data. Tested applications, recommended concentrations, and dilution schemes are Not specified for this item; refer to CoA/Spec Sheet.
General guidance (for planning only; not item-specific)
Electrophysiology: Prepare DMSO stocks; dilute into external/internal solutions immediately before recording. Confirm final DMSO concentration does not affect cell viability or seal quality.
Cell-based assays: Validate dose–response with appropriate replicates and include vehicle controls. Monitor compound precipitation visually and by absorbance if possible.
Storage of working solutions: Use freshly prepared dilutions; discard after the experiment unless stability has been established in your system.
Always defer to your laboratory SOPs and the SDS for handling and disposal.
UCL1684 is widely cited as a potent small‑molecule inhibitor of small‑conductance Ca2+‑activated K+ channels (SK/KCa2; commonly SK1–SK3). These channels contribute to afterhyperpolarization currents and regulate neuronal and other excitable cell firing patterns.
Selectivity: Literature notes high functional potency at SK channels relative to many other K+ channel families; however, selectivity can be assay‑ and species‑dependent. Users should confirm target engagement in their system.
Research applications: Employed to delineate SK‑channel roles in electrophysiology, synaptic integration, vascular tone studies, and cellular signaling. Tool‑compound use includes benchmarking against peptide blockers (e.g., apamin) and assessing structure–activity relationships among KCa modulators.
Practical assay considerations
Because SK channels are Ca2+‑dependent, experimental design should control intracellular Ca2+ buffering (e.g., EGTA vs. BAPTA) and membrane potential. Include appropriate vehicle controls and, when possible, rescue or orthogonal modulation experiments to support mechanistic conclusions.
Compliance note
This product is supplied for research use only. No claims are made regarding clinical utility or diagnostic performance.
Buffer Applications
Applicability
UCL1684 is not a buffering agent. Buffer systems are only relevant here as vehicles for delivering the compound in biological assays.
General guidance
Common assay buffers: PBS, HEPES‑buffered saline, or physiological ionic solutions for patch‑clamp or imaging experiments.
Preparation: Dissolve UCL1684 first in DMSO to make a concentrated stock, then dilute into buffer with vigorous mixing to minimize precipitation. Maintain final DMSO at assay‑compatible levels.
Filtration: If sterility is required, filter the final working solution through a 0.22 µm membrane. Confirm compound stability under your buffer conditions (light, pH, temperature).
Item-specific note
Exact aqueous solubility limits, pH stability ranges, and precipitation thresholds for this SKU are Not specified for this item; refer to CoA/Spec Sheet.
Green Alternatives
Scope
As a research ligand, UCL1684 is not a process solvent or common reagent, so conventional green‑chemistry substitution frameworks (e.g., replacing chlorinated solvents) are not typically applicable.
General considerations
If your workflow involves dissolving UCL1684, consider greener co‑solvents and vehicles where compatible with assay performance:
Favor aqueous buffers after minimal DMSO stock dilution to reduce organic solvent burdens.
Evaluate bio‑based or lower‑toxicity solvents (e.g., ethanol) for intermediate dilutions if solubility permits.
Minimize waste by preparing right‑sized aliquots to avoid repeated freeze‑thaw and disposal of expired solutions.
Comparison (general)
DMSO vs ethanol: DMSO offers broader solubility but higher persistence; ethanol is more benign but may limit concentration and can impact certain assays. Select based on solubility and assay constraints.
Item-specific note
No greener “alternative compound” exists for the mechanism of action that UCL1684 provides; if a different pharmacological profile is acceptable, consult literature for other SK‑channel tool compounds with suitable handling profiles.
Pharmaceutical Uses
Scope
This product is provided strictly for research use only. It is not formulated, approved, or intended for human or veterinary use, as a drug substance, or as an excipient.
General context (literature)
UCL1684 is described in the research literature as a pharmacological tool for SK channel studies. While such compounds can inform early discovery, there are no claims here regarding GMP status, pharmacopeial monographs, or suitability for clinical development.
Manufacturing/formulation notes
If used in preclinical research formulations (in vitro or ex vivo), typical vehicles may include DMSO with aqueous dilution, or PEG/solutol systems where necessary. Validate compatibility and stability empirically.
Regulatory note
No pharmacopeial status, impurity limits, or excipient roles are specified for this SKU. All pharmaceutical-use attributes for this item are Not specified for this item; refer to CoA/Spec Sheet.
Physical Properties
Item-specific properties (from Product Data)
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
Literature/general physical data (for context only; not item specifications)
Melting point (literature): Tool compounds in this class are typically crystalline solids with melting points often >100 °C; consult primary references for UCL1684 specifically.
Solubility (literature): Commonly prepared as stock solutions in DMSO for biological assays; aqueous solubility varies by salt/counter‑ion. Specific solubility for this SKU is not specified.
LogP/logD (literature): SK-channel ligands are often moderately lipophilic to enable membrane access; exact partition data should be confirmed from the CoA or experimental determination.
Practical notes
If the item is supplied as a free base or neutral form, dissolution in anhydrous DMSO, DMF, or ethanol is typical for assay stocks; for salts, water or buffered aqueous mixtures may be suitable. Always filter sterilize assay stocks if required by your protocol.
For quantitative work, determine extinction coefficients, purity by HPLC, and water content (e.g., Karl Fischer) in-house if not provided. All definitive values for this SKU: Not specified for this item; refer to CoA/Spec Sheet.
Quality and Grades
Item-specific grade
Grade/Purity: Moligand™ (as provided). This designation indicates a research‑use ligand standard suitable for screening, target engagement studies, and assay development.
What Moligand™ implies (general guidance)
Identity and purity control: Typically encompasses rigorous identity verification (e.g., NMR/HRMS) and high chemical purity suitable for biological assays. Exact acceptance criteria, residual solvent limits, water content, and chromatographic purity for this SKU are Not specified for this item; refer to CoA/Spec Sheet.
Assay suitability: Low levels of UV‑active or reactive impurities are favored to minimize assay interference. If you require low‑UV baselines for LC/UV analytics, request spectral data for this lot.
Counter‑ion/salt form: The form (free base vs. salt) strongly affects solubility and handling. The specific form for this SKU is Not specified for this item; refer to CoA/Spec Sheet.
Recommendations
For screening or SAR studies, document lot-to-lot continuity with an internal reference HPLC trace and NMR. If performing quantitation, obtain exact purity for mass-balance corrections.
If your application demands trace-metal, peroxide, or water specifications, consult the CoA; any values not listed here are Not specified for this item; refer to CoA/Spec Sheet.
Reaction and Applications
Chemical reaction applications
This product is sold as a bioactive small molecule (ligand) and is not typically employed as a stoichiometric reagent, catalyst, or solvent in synthetic transformations. Consequently, named organic reactions and reagent roles are generally not applicable.
Research/assay applications (literature context; not item-specific claims)
UCL1684 is widely referenced as a potent tool compound for studying small‑conductance Ca2+‑activated K+ (SK/KCa2) channels in electrophysiology, calcium imaging, and patch‑clamp assays. It is used to dissect SK‑channel contributions to membrane excitability and afterhyperpolarization currents.
Typical use scenarios include validation of SK‑channel involvement in cellular phenotypes, benchmarking against other SK modulators (e.g., apamin), and use in pharmacological profiling.
Practical guidance
Prepare concentrated DMSO stocks (e.g., 1–10 mM) and dilute into assay buffers immediately before use to minimize precipitation; maintain final DMSO at assay‑compatible levels.
Include vehicle controls and, where possible, an orthogonal modulator for specificity controls.
Item-specific note
Manufacturer-validated application data are not provided for this SKU. Any particular concentrations, incubation times, or potencies should be determined empirically, and all critical parameters are Not specified for this item; refer to CoA/Spec Sheet and SDS.
Reaction Conditions
Not typically applicable
UCL1684 is a research ligand, not a process reagent. There are no standard “reaction conditions” associated with using UCL1684 as a chemical reagent.
Assay preparation conditions (general/literature)
Stock solutions: Commonly prepared at 1–10 mM in anhydrous DMSO; store aliquots protected from light and moisture. Working concentrations for electrophysiology or functional assays are determined empirically.
Vehicle control: Match final DMSO percentage in control wells/cells.
Stability: Assess short‑term stability at room temperature and longer‑term stability at 2–8 °C or −20 °C in sealed aliquots. Avoid repeated freeze–thaw cycles by preparing single‑use aliquots.
Item-specific note
Exact concentration ranges, incubation times, and stability data for this SKU are Not specified for this item; refer to CoA/Spec Sheet and SDS.
Safety and Handling
GHS/SDS information
Signal word: Not specified for this item; refer to SDS.
Hazard statements (H‑statements): Not specified for this item; refer to SDS.
Pictograms/GHS classification: Not specified for this item; refer to SDS.
General laboratory precautions (good practice)
Handle in a chemical fume hood to avoid inhalation of dust or aerosols.
Wear appropriate PPE: lab coat, nitrile gloves, and safety glasses; upgrade to chemical splash goggles and appropriate gloves if handling concentrated stock solutions or during weighing.
Avoid skin and eye contact; prevent ingestion and inhalation. Wash thoroughly after handling.
Incompatibilities and stability (general guidance)
Protect from strong oxidizers and strong acids/bases that could degrade heteroaromatic/amide functionalities typical of small-molecule ligands.
Avoid prolonged exposure to light and moisture if the compound is photosensitive or hygroscopic (verify on CoA/SDS for this SKU).
First-aid overview (consult SDS for authoritative instructions)
Inhalation: Move to fresh air; seek medical attention if symptoms persist.
Skin contact: Wash with soap and water; remove contaminated clothing.
Eye contact: Rinse cautiously with water for several minutes; seek medical advice if irritation persists.
Ingestion: Rinse mouth; do not induce vomiting; seek medical attention.
Waste disposal
Dispose of in accordance with institutional and local regulations for organic laboratory chemicals. Defer to the SDS for specific disposal guidance.
Solvent Selection
Applicability
UCL1684 is a small-molecule research ligand rather than a process solvent. Solvent selection here pertains to dissolving the compound for assay stocks and sample preparation.
General/literature guidance for SK‑ligand handling
Primary stock solvent: DMSO is commonly used due to broad solubility and compatibility with biological assays at low final percentages (e.g., ≤0.1–0.5% v/v). Ethanol or DMF may be alternatives.
Aqueous work: If supplied as a salt, partial aqueous solubility can improve; otherwise, co‑solvent systems (DMSO→buffer dilution) are standard.
Buffer compatibility: Phosphate‑buffered saline (PBS), HEPES, or physiological buffers are typical vehicles after preparing a DMSO concentrate. Validate that final DMSO content does not affect your readout.
Selection considerations
Polarity and ionization: If the compound bears basic or acidic centers (common in channel ligands), pH can modulate solubility; adjust buffer pH accordingly after initial DMSO dissolution.
Adsorption: Minimize adsorption losses by using low‑binding plasticware or silanized glass for low‑nanomolar applications.
Item-specific note
Exact solubility limits, pKa, and partition data for this SKU are Not specified for this item; refer to CoA/Spec Sheet.
Storage and Reconstitution
Item-specific conditions (from Product Data)
Storage: Room temperature.
Shipped in: Not specified for this item; refer to CoA/Spec Sheet.
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Reconstitution guidance (general)
If supplied as a solid: Equilibrate to room temperature in a desiccator before opening. Prepare a concentrated stock solution in anhydrous DMSO (commonly 1–10 mM), then aliquot into amber vials or low‑bind tubes.
If supplied as a solution: Mix well after arrival; note the solvent and concentration on the CoA. Store according to label instructions.
Handling and stability (general best practices)
Protect from excessive light and humidity. Use nitrogen backfill for long‑term storage of DMSO stocks when feasible. Avoid repeated freeze–thaw cycles by preparing single‑use aliquots.
Before critical experiments, verify integrity by analytical HPLC and/or MS. Record preparation dates and lot numbers in your ELN.
Notes
Any specific shelf‑life, retest date, counter‑ion form, and solubility for this SKU are Not specified for this item; refer to CoA/Spec Sheet.
For research use only.
Structure and Identity
Item-specific facts (from Product Data)
Product name: UCL1684 (SKU U614616)
CAS: 201147-18-4
PubChem CID: 656733
Grade: Moligand™
InChIKey: 135400 (as provided in the product data)
SMILES: Not specified for this item; refer to CoA/Spec Sheet.
Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
General/literature context
UCL1684 is widely cited in the literature as a small‑molecule ligand used to probe small‑conductance Ca2+‑activated K+ (SK/KCa2) channels. It is frequently discussed alongside apamin as an SK channel tool compound. This contextual information is provided for research background only; consult the CoA for definitive structural identifiers for this catalog item.
Descriptive structural notes (literature, not item-specific)
Literature sources describe UCL1684 as a heteroaromatic small molecule designed for high-affinity interaction with KCa2 family channels. Exact ring systems, substituents, and stereochemistry should be verified from authoritative structural databases or the item’s CoA/Spec Sheet for this SKU.
Identity verification guidance
For unambiguous identification in your lab, verify CAS and structural keys against the CoA and independently confirm by orthogonal methods as needed (e.g., HRMS, 1H/13C NMR, HPLC retention time vs. reference).
Synthetic Utility
Applicability
UCL1684 is sold as a finished small‑molecule research ligand rather than as a synthetic building block. It is not commonly used as a reagent, catalyst, or intermediate in general organic synthesis.
General/literature context
Publications focus on UCL1684 as a bioactive endpoint for pharmacology rather than on its use to effect chemical transformations. Derivatives may appear in SAR campaigns to optimize potency/selectivity at SK channels; such efforts involve standard heteroaromatic coupling, amide formation, and protection/deprotection strategies typical of medicinal chemistry.
Recommendations
If your objective is to synthesize analogs, consult the primary literature for reported routes, paying attention to late‑stage functionalizations that preserve core pharmacophores. Protecting group compatibility, ligand protonation state, and salt selection can critically influence purification and solid‑state properties.
Item-specific note
Any reagent‑grade specifications (e.g., water, metals, residual solvents) enabling downstream synthesis are Not specified for this item; refer to CoA/Spec Sheet.
Target Specificity
Item-specific information
Target, selectivity profile, and potency data are not provided in the product data for this SKU. Accordingly, specific target annotations are Not specified for this item; refer to CoA/Spec Sheet.
General/literature context (for background only)
The name UCL1684 is widely used in literature for a small‑molecule tool targeting small‑conductance Ca2+‑activated K+ channels (SK/KCa2). If target specificity is critical for your work, verify the structural identity and potency data for this exact SKU against primary literature and the CoA before use.
Frequently Asked Questions
What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at room temperature.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 201147-18-4. InChIKey HZWVJPDDZQOYGA-UHFFFAOYSA-P.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
Need help choosing the grade?
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
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