UK-371804 - 10mM in DMSO , CAS No.256477-09-5

CAS: 256477-09-5 Cat. No.: U656378 Formula: C₁₄H₁₆ClN₅O₄S Molecular Weight: 385.83 PubChem CID: 9952109

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

UK-371804 is a urokinase-type plasminogen activator ( uPA ) inhibitor with a K i of 10 nM.

In Vitro

UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC 50 =0.89 μM). UK-371804 has its excellent enzyme potency (K i =10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Ki: 10 nM (uPA)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

UK-371804 is a urokinase-type plasminogen activator ( uPA ) inhibitor with a K i of 10 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl
• PubChem CID: 9952109
• MeSH Entry Terms: 2-(((4-chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)isobutyric acid;UK 371,804;UK 371804;UK-371,804;UK-371804;UK371,804;UK371804
• Molecular Weight: 385.83

Associated Targets(Human)

PLAU Tchem Urokinase-type plasminogen activator (3 Activities)

Discover Target: PLAU

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 256477-09-5, the molecular formula is C14H16ClN5O4S, and the molecular weight is 385.83 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.