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UMB298 - 10mM in DMSO , CAS No.2266569-73-5
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor
In Vitro
UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth. UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MOLM13 and MM cells Concentration: 0.01~10 μM Incubation Time: 50 days Result: Inhibited cells growth. Western Blot AnalysisCell Line: MOLM13 cells Concentration: 1~10 μM Incubation Time: 2 hours Result: Reduced the H3K27ac level similar to CBP30 and caused MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. RT-PCRCell Line: MOLM13 cells Concentration: 3 μM Incubation Time: 2 hours Result: Down-regulated MYC expression.
IC50& Target:BRD4 5193 nM (IC 50 )
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
| Isomeric SMILES | CC1=C(C(=NO1)C)C2=CC3=NC(=C(N3C=C2)NC4CCCCC4)CCC5=CC(=C(C=C5)OC)Cl |
|---|---|
| PubChem CID | 137409212 |
| Molecular Weight | 479.01 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Solution Calculators
Reviews
Customer Reviews
Frequently Asked Questions
How should this product be stored?
Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 2266569-73-5, the molecular formula is C27H31ClN4O2, and the molecular weight is 479.01 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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