VES-POFP , CAS No.V1445655

CAS: V1445655 Cat. No.: V1445655 Formula: C₃₉H₅₃F₅O₅ Molecular Weight: 696.83

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

VES-POFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Molecular Weight

696.83

Application Protocols

Item-specific facts (from Product Data)

• No tested applications or protocols are specified for this item.

General working guidance for small-molecule library compounds

• Preparing a stock solution
  • Allow vial to equilibrate to room temperature in a desiccator to avoid moisture condensation.
  • Quickly weigh the required amount; prepare a 10–50 mM stock in dry DMSO or ethanol. Record exact concentration based on weight and solvent density.
  • Vortex and sonicate if needed; filter through a 0.22 µm PTFE syringe filter for particle removal.
• Aliquoting and use
  • Dispense single-use aliquots to minimize freeze–thaw cycles.
  • For biological assays, keep final DMSO ≤0.5–1% v/v unless otherwise validated.
  • Mix thoroughly after dilution; inspect for precipitation.
• Analytical confirmation
  • Verify concentration by UV–Vis if the compound has a known extinction coefficient or by quantitative NMR (qNMR) when feasible.
• Plate handling (HTS context)
  • Use low-bind labware to reduce adsorption losses.
  • Maintain cold chain only if stability data indicate a benefit; avoid repeated temperature cycling.

Biological Roles

Item-specific facts (from Product Data)

• No biological function, mechanism, or target information is provided for this item.

General guidance

• Absent a disclosed structure or literature references, no biological roles can be assigned or inferred.
• If used in biochemical assays, confirm identity and purity under assay conditions and determine compound stability in the chosen buffer/cosolvent over the assay timeframe.
• Implement appropriate controls: vehicle-only, heat-inactivated, and orthogonal readouts to de-risk assay artifacts (aggregation, fluorescence interference, redox cycling).

Note

• This product is supplied strictly for research use only. No clinical, diagnostic, or therapeutic claims are made or implied.

Buffer Applications

Not typically applicable

• VES-POFP is listed as a small-molecule/compound library item and is not itself a buffering agent.

General practical notes (if dissolving compound into buffers)

• Vehicle approach: Prepare a concentrated stock in DMSO or ethanol, then dilute into the buffer to a low final cosolvent percentage (commonly ≤0.5–1% v/v) to mitigate effects on pH and biological systems.
• Buffer selection: Use assay-appropriate buffers (e.g., phosphate, HEPES, Tris) and verify that pH remains stable after compound addition; some compounds can alter apparent pH or precipitate near their pKa.
• Filtration: If sterile conditions are required, sterile-filter the final working solution with a compatible membrane (PTFE or PES, depending on solvent fraction).
• Surfactants: For compounds prone to aggregation, a low percentage of nonionic surfactant (e.g., 0.01–0.05% Tween-20) can help maintain dispersion—verify assay compatibility.
• Stability check: Monitor for precipitation, color change, or UV–Vis drift over the assay window; prepare fresh solutions as needed.

Green Alternatives

Item-specific facts (from Product Data)

• No process or solvent information is specified for this item.

General guidance (green chemistry framing for handling/dissolution)

• Prefer inherently safer solvents for dissolution, workup, and purification when compatible with the compound:

Small comparison (general)

• Water/Buffer: Greenest option; limited by solubility and stability.
• Ethanol/Isopropanol: Low toxicity, renewable sourcing possible; good for many organics.
• Ethyl acetate: Biodegradable, low toxicity; useful for extractions and crystallizations.
• 2-MeTHF or CPME: Greener ethers versus THF/Et2O; higher stability and favorable safety profiles.
• Acetone/MeTHyl ethyl ketone: Readily biodegradable; strong solvency; check assay compatibility.
• Avoid when possible: Chlorinated solvents (DCM/CHCl3), NMP/DMF (reproductive toxicity), unless required for performance.

Trade-offs

• Solubility/assay constraints may necessitate DMSO or acetonitrile for analytical work. Minimize volumes and ensure proper waste segregation.
• If the compound is moisture- or base-sensitive, greener protic solvents may compromise stability—confirm via small stress tests.

Operational tips

• Use microscale screening to identify the greenest viable solvent.
• Recycle solvents when feasible and employ low-temperature evaporation to reduce energy consumption.

Pharmaceutical Uses

Item-specific facts (from Product Data)

• No pharmacopeial status, excipient role, or formulation guidance is specified for this item; research use only.

General context

• Without structural and toxicological data, this material is not suitable for clinical development, cGMP manufacturing, or human/animal administration.
• If explored as a reference material in pre-formulation research:
  • Determine solubility across pH 1–8 buffers with and without cosolvent.
  • Evaluate chemical stability (acid/base, oxidative, photolytic) and solid-state form (XRPD, DSC) to inform hypothetical formulation routes.
  • Document residual solvent profile and water content if any drying/recrystallization is performed.

Regulatory note

• No pharmacopoeial monograph is implied. For any work beyond early discovery, generate or obtain full CMC-relevant data under appropriate quality systems.

Physical Properties

Item-specific facts (from Product Data)

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Physical state (solid/liquid), color, odor: Not specified for this item; refer to CoA/Spec Sheet.

Literature/computed values

• Boiling point, melting point, density, refractive index, logP/logD, pKa, solubility: Not available without structure; not specified for this item.

General guidance for characterization (methods to determine properties upon receipt)

• Melting point (for solids): Use DSC or capillary method to assess phase behavior and potential polymorphism.
• Thermal stability: TGA/DSC under N2 for onset of decomposition; record any mass-loss events (solvent/water of crystallization).
• Solubility screen: Perform a tiered micro-scale screen at room temperature and 37 °C.
  • Polar aprotic: DMSO, DMF, acetonitrile
  • Protic: water (with cosolvent), methanol, ethanol, isopropanol
  • Nonpolar: ethyl acetate, dichloromethane, toluene, heptane
• Partitioning: If structure becomes available, estimate logP/logD by cLogP calculators; otherwise determine experimentally via shake-flask (octanol/water) or chromatographic retention (IAM/PHI columns).
• Spectra: Record UV–Vis (200–400 nm) in a compatible solvent to guide HPLC detection; collect FTIR and NMR for identity and impurity profiling.

Note: Treat all property values as method-dependent and batch-specific; the authoritative specifications are those on the CoA for the shipped lot.

Quality and Grades

Item-specific facts (from Product Data)

• Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.

General context for small-molecule library items

• Purity reporting: Library compounds are commonly supplied with HPLC/UPLC purity (e.g., area% at 220–254 nm) and LC–MS identity confirmation. If a UV cutoff or PDA purity is required for your method, request the detector wavelength and chromatographic conditions used.
• Grade definitions (general)
  • Research grade: Suitable for exploratory R&D; specifications defined by supplier tests (e.g., HPLC purity, MS match). Not for clinical or GMP use.
  • Analytical grade/HPLC grade: Typically indicates very low non-volatile residue and low UV background (primarily for solvents), not applicable unless specified.
• Stabilizers/additives: None specified for this item. If stability is a concern (e.g., hydrolysis, oxidation), suppliers may add trace stabilizers; presence/identity must be disclosed on the CoA/SDS.
• Trace metals, water content, and residual solvents: Not specified for this item; refer to CoA/Spec Sheet. For critical applications, perform KF and GC residual solvent profiling on receipt.

Recommendations

• Request and archive lot-specific CoA and SDS.
• Verify purity and identity under your analytical conditions (orthogonal methods) before biological testing or scale-up chemistry.
• If purity is below your acceptance criterion, consider re-purification (e.g., preparative HPLC) and document the new specification internally.

Reaction and Applications

Item-specific facts (from Product Data)

• Manufacturer applications: Not provided beyond inclusion in a small-molecule/compound library category.

Context and typical use of library compounds (general)

• Screening and discovery: Such items are commonly used for method development, reference standard work, and feasibility screens in chemical biology or medicinal chemistry. No biological activity or target is implied for this item without supporting data.
• Analytical applications: Calibration of LC–MS methods, retention-time indexing, and stress-testing workflows (photolysis, hydrolysis, oxidation) to develop stability-indicating methods.
• Derivatization studies: If functional groups permit, users may explore prodrug masking, isotopic labeling, or linker installation for affinity matrices—only after confirming structure and reactivity.

Practical tips

• Start with microgram-to-milligram quantities for any transformation or stability study.
• Characterize baseline purity and identity (LC–MS, NMR) before and after any operation.
• If reactivity is unknown, avoid strong acids/bases, high temperatures, or metal-catalyzed conditions until a small stress screen defines tolerance.

Not applicable

• Without a disclosed structure, specific named reactions, mechanisms, or selectivity notes cannot be provided for this item.

Reaction Conditions

Not applicable for this item without a known structure.

General guidance (if exploring transformations or stability)

• Solvent: Start with benign solvents (EtOAc, ethanol) or DMSO/MeCN for analytical runs; escalate to DMF/THF only if needed and compatible.
• Temperature: Begin at ambient; if necessary, increment in 10 °C steps while monitoring by TLC/LC–MS.
• Catalysts/reagents: Choose the mildest plausible options; avoid strong nucleophiles/electrophiles until functionality is understood.
• Atmosphere: Default to inert gas (N2/Ar) if oxygen/moisture sensitivity is unknown.
• Time/course: Use timepoints (e.g., 0.5, 2, 6, 24 h) to establish kinetics of change.

Analytical tracking

• LC–MS to detect new mass channels; PDA to observe chromophore changes; 1H NMR for gross conversion and impurity emergence.

Note

• Expected yields or selectivities cannot be provided absent literature precedents for a known structure.

Safety and Handling

Item-specific facts (from Product Data)

• GHS classification, pictograms, signal word, and H-statements: Not specified for this item; refer to the SDS.
• Storage conditions: Store at −20 °C.
• Shipping: Ice chest + ice pads.
• Research use: For research use only.

General safety guidance (not a substitute for SDS)

• Handle in a fume hood with appropriate PPE: lab coat, safety glasses, and chemical-resistant gloves (e.g., nitrile). Avoid inhalation of dusts/aerosols and skin contact.
• Unknown hazard class: Treat as potentially harmful/irritant. Avoid ingestion and environmental release. Keep containers tightly closed and clearly labeled.
• Incompatibilities: Until functional groups are known, segregate from strong oxidizers and acids/bases. Avoid reactive metals if halogenated/acidic functionalities are suspected.
• Hygroscopicity/photosensitivity: If appearance changes or discoloration occurs upon light/moisture exposure, protect from light and store with desiccant; consider inert-gas backfill for opened containers.
• First aid (overview):
  • Skin/eye contact: Rinse with water for ≥15 min; remove contaminated clothing; seek medical attention as needed.
  • Inhalation: Move to fresh air; monitor breathing; seek medical attention.
  • Ingestion: Rinse mouth; do not induce vomiting; seek medical attention.
• Spill response: Contain with inert absorbent; collect for disposal according to institutional and local regulations.

Always consult the lot-specific SDS for authoritative hazard information and institutional SOPs for handling practices.

Solvent Selection

Item-specific facts (from Product Data)

• No solubility or solvent preferences are specified for this item; refer to CoA/Spec Sheet.

General guidance for small molecules of unknown structure

• Primary stock solutions: DMSO is the most common solvent for research libraries due to broad solvency and assay compatibility at low final percentages.
• Solubility screening workflow (micro-scale)
  1. Start with DMSO at 10–50 mg/mL. If insoluble, warm gently (≤40 °C) and sonicate.
  2. If needed, evaluate DMF, NMP, ethanol, methanol, acetonitrile.
  3. For aqueous work, prepare cosolvent mixtures (e.g., 10–50% DMSO or ethanol in buffer). Adjust pH only if the ionization state is known.
  4. For nonpolar matrices, test EtOAc, MTBE, toluene, CPME, or heptane.
• Dielectric/polarity selection: Without structural data, bracket the polarity space—use a small panel spanning polar aprotic, protic, and nonpolar to quickly locate a working medium.
• Analytical compatibility: Choose HPLC solvents that minimize background and are compatible with your detectors (e.g., MeCN/H2O with 0.1% FA or MeOH/H2O with 0.1% FA for LC–MS). For normal-phase, ensure compound stability in nonpolar solvents.

Comparison of common dissolution choices (general)

• DMSO: Highest success rate, hygroscopic; limit final assay % to avoid cytotoxic effects.
• Ethanol: Good for many organics; higher assay tolerance than DMSO.
• Acetonitrile: Excellent LC–MS compatibility; moderate solvency.
• 2-MeTHF/CPME: Useful for workup/crystallization if nonpolar solubility is adequate.

Storage and Reconstitution

Item-specific facts (from Product Data)

• Storage conditions: Store at −20 °C.
• Shipping conditions: Ice chest + ice pads.

General best practices

• Container: Keep tightly closed in original container. If the compound is moisture-sensitive (unknown), store with desiccant; consider inert-gas backfill after first opening.
• Light: If any discoloration is observed or if the CoA/SDS indicates photosensitivity, protect from light (amber vial, foil wrap).
• Reconstitution
  • Select solvent based on a small solubility screen; DMSO or ethanol are common for initial stock solutions.
  • Prepare concentrated stocks (e.g., 10–50 mM) and dispense single-use aliquots to minimize freeze–thaw and headspace moisture ingress.
  • Label aliquots with compound ID, solvent, concentration, and date.
• Stability monitoring: Periodically check by LC–MS/HPLC for degradation or precipitation, especially after thawing.
• Freeze–thaw: Avoid repeated cycles; thaw at room temperature, mix gently, and immediately return unused material to −20 °C.

Authoritative references

• For any lot-specific handling constraints (e.g., hygroscopicity, hydrate/solvate form), consult the CoA and SDS supplied with the product.

Structure and Identity

Item-specific facts (from Product Data)

• Product name: VES-POFP (SKU: V1445655)
• CAS: V1445655 (catalog placeholder)
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

Interpretive notes (general)

• Structural features, ring systems, and functional groups cannot be described without a disclosed structure.
• If you have a batch CoA/SDS, extract identifiers (CAS, MF, MW, SMILES) to enable cheminformatics workflows, LC-MS method development, and impurity tracking.
• For library compounds, we recommend confirming identity by orthogonal methods upon receipt:
  • High-resolution MS (accurate mass, isotope pattern)
  • 1H/13C NMR (solvent chosen after solubility screen)
  • HPLC/UPLC purity check with PDA and MS detection
  • Optional: FTIR for functional-group fingerprints

2D structure description

• Not available; a text description requires at least a connectivity graph. Please consult the CoA or contact Aladdin Scientific for structural disclosure where available.

Synthetic Utility

Not typically applicable

• With no disclosed structure or functional-group information, VES-POFP cannot be positioned as a synthetic reagent or building block.

General considerations (if users intend derivatization)

• Confirm structure and purity (NMR, HRMS, HPLC) prior to any transformations.
• Run micro-scale reactivity probes under neutral conditions first; then explore mild base/acid or catalytic hydrogenation/oxidation only if stability permits.
• Map chemoselectivity using small panels of conditions rather than committing to a single route.
• Track mass balance meticulously; unknown side reactions can complicate interpretation.

Documentation

• Record exact conditions, solvents, and workup procedures to build an internal knowledge base for the compound’s reactivity profile.

Target Specificity

Item-specific facts (from Product Data)

• No target, binding data, or selectivity information is provided for this item.

General statement

• Without structural and bioactivity data, no inferences can be made about molecular targets or selectivity profiles. If used in discovery assays, apply broad counter-screening to identify assay-interference liabilities (e.g., PAINS motifs, redox cycling) only after structural information is available.

Frequently Asked Questions

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is V1445655, the molecular formula is C39H53F5O5, and the molecular weight is 696.83 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.