VU 6008667 - ≥98% , CAS No.2092923-21-0
In stock
SKU
V647507
VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC 50 s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration
In Vivo
VU 6008667 (1 mg/kg)/PO (3 mg/kg, solution dose) displays a diminished elimination half-life (t 1/2 =2.3 hr) driven by a smaller volume (V ss =7.4 L/kg) and higher clearance (CL p =82 mL/min/kg), with moderate oral bioavailability (17% F) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: RAT (PK study) Dosage: 1 mg/kg; 3 mg/kg Administration: oral adminstration Result: Had a desired short half-life in rat (t 1/2 = 2.3 hr), with moderate oral bioavailability (17% F).
Form:Solid
IC50& Target:IC50: 1.2 μM (Human M5),1.6 μM (Rat M5)
More Information
| CAS | 2092923-21-0 |
|---|---|
| Specifications & Purity | ≥98% |
| Storage | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC 50 s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration In Vivo VU 6008667 (1 mg/kg)/PO (3 mg/kg, solution dose) displays a diminished elimination half-life (t 1/2 =2.3 hr) driven by a smaller volume (V ss =7.4 L/kg) and higher clearance (CL p =82 mL/min/kg), with moderate oral bioavailability (17% F) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: RAT (PK study) Dosage: 1 mg/kg; 3 mg/kg Administration: oral adminstration Result: Had a desired short half-life in rat (t 1/2 = 2.3 hr), with moderate oral bioavailability (17% F). Form:Solid IC50& Target:IC50: 1.2 μM (Human M5),1.6 μM (Rat M5) |
| Solubility | DMSO : 100 mg/mL (227.87 mM; Need ultrasonic) |
| PubChem CID | 134824563 |
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