VU6028418 - ≥99% , CAS No.2649803-05-2

CAS: 2649803-05-2 Cat. No.: V651101 Formula: C₂₃H₂₇F₃N₄O Molecular Weight: 432.48

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

VU6028418 is a potent, highly selective and orally bioavailable M 4 mAChR antagonist with an IC 50 of 4.1 nM against hM 4

In Vivo

VU6028418 is orally bioavailable . In Vivo PK Parameters for VU6028418 parameter rat (SD) a mouse (CD-1) a dog (beagle) a dose (mg/kg) iv/po 1/10 1/3 1/3 CL p (mL/min/kg) 6.1 17 43 V ss (L/kg) 6.7 10.6 8.5 elimination t 1/2 (h) 13 NC 15 C max (ng/mL) po 17 000 181 70 T max (h) po 1.5 6.67 17 AUC 0-inf (ng/mL•h) po 30 000 NC 1100 F (%) po ≥100 ≥100 86 total brain/total plasma (K p ) 6.4 ND ND unbound brain/unbound plasma (K p,uu ) 0.61 ND ND CSF/plasma unbound (K p,u ) 0.24 ND ND a Values represent means from two to three animals. ND = not determined. NC = not calculated; there was insufficient data to define the elimination phase (i.e., C max was one of the last three time points). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: SD rat, CD-1 mouse and beagle dog Dosage: 1, 3 and 10 mg/kg Administration: Intravenous injection or oral administration (Pharmacokinetic Analysis) Result: Showed good pharmacokinetic results.

Form:Solid

IC50& Target:mAChR4

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

VU6028418 is a potent, highly selective and orally bioavailable M 4 mAChR antagonist with an IC 50 of 4.1 nM against hM 4.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

Canonical Smiles

FC1=CC(F)=C(F)C(C2=CC=C(N[C@H]3C[C@@](CN(CC4CCOCC4)C5)([H])[C@@]5([H])C3)N=N2)=C1

Molecular Weight

432.48

Chemical and Physical Properties

• Solubility: DMSO : 5.56 mg/mL (12.86 mM; ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C)