WM-3835 - ≥98% , CAS No.2229025-70-9

CAS: 2229025-70-9 Cat. No.: W414487 Formula: C₂₀H₁₇FN₂O₄S Molecular Weight: 400.42 PubChem CID: 134581412

GRADE & PURITY ≥98%

Synonyms

[1,​1'-​Biphenyl]​-​3-​carboxylic acid,4-​fluoro-​5-​methyl-​,2-​[(3-​hydroxyphenyl)​sulfonyl]​hydrazide

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

WM-3835 WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.

Targets

KAT7

In vitro

WM-3835 activates apoptosis while inhibites OS cell proliferation, migration and invasion. The activity of WM-3835 is ified in HBO1-KO OS cells. Also, the HBO1 inhibitor is non-cytotoxic in HBO1-low human osteoblasts, which indicates that the anti-OS cell efficacy of WM-3835 is primarily through HBO1 inhibition.

In vivo

intraperitoneal injection of a single dose of WM-3835 potently inhibites OS xenograft growth in SCID mice.

Cell Research(from reference)

Cell lines：Primary human OS cells (pOS-1 cells, pOS-2 cells) 

Concentrations：1 μM, 5 μM, 10 μM, 25 μM 

Incubation Time：24 h, 48 h, 72 h, 96 h 

Specifications

Synonyms

[1,​1'-​Biphenyl]​-​3-​carboxylic acid,4-​fluoro-​5-​methyl-​,2-​[(3-​hydroxyphenyl)​sulfonyl]​hydrazide

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

Pubchem Sid

504773168

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504773168

Canonical Smiles

CC1=CC(=CC(=C1F)C(=O)NNS(=O)(=O)C2=CC=CC(=C2)O)C3=CC=CC=C3

IUPAC Name

2-fluoro-N'-(3-hydroxyphenyl)sulfonyl-3-methyl-5-phenylbenzohydrazide

InChIKey

KVJFJJXCBRSCDY-UHFFFAOYSA-N

INCHI

1S/C20H17FN2O4S/c1-13-10-15(14-6-3-2-4-7-14)11-18(19(13)21)20(25)22-23-28(26,27)17-9-5-8-16(24)12-17/h2-12,23-24H,1H3,(H,22,25)

PubChem CID

134581412

Molecular Weight

400.42

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: Benzenesulfonamides 2-halobenzoic acids and derivatives m-Toluamides Benzenesulfonyl compounds Benzoyl derivatives Fluorobenzenes 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Sulfonohydrazides Hydrazinosulfonyl compounds Aryl fluorides Vinylogous halides Carboxylic acids and derivatives Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Biphenyl - Halobenzoic acid or derivatives - 2-halobenzoic acid or derivatives - Benzenesulfonamide - Benzenesulfonyl group - M-toluamide - Toluamide - Benzoic acid or derivatives - Benzoyl - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Toluene - Phenol - Halobenzene - Fluorobenzene - Hydrazinosulfonyl compound - Sulfonohydrazide - Aryl halide - Aryl fluoride - Vinylogous halide - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 80 mg/mL (199.79 mM); Ethanol: 80 mg/mL (199.79 mM); Water: Insoluble
• Sensitivity: Light sensitive
• Molecular Weight: 400.400 g/mol
• XLogP3: 3.800
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 400.089 Da
• Monoisotopic Mass: 400.089 Da
• Topological Polar Surface Area: 104.000 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 633.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1