WRR139 - ≥99% , CAS No.2138924-36-2

CAS: 2138924-36-2 Cat. No.: W657043 PubChem CID: 135300204

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer . WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells.

Form:Solid

In Vitro:WRR139 (0.01-100 μM; 1 h) inhibits NGLY1 in vitro and impairs processing of Nrf1 in HEK293 cells. WRR139 (5 μM; 18 h) disrupts Nrf1 processing, location, and activation in HEK293 cells. WRR139 (1 μM; 24 h) enhances the cytotoxicity of Carfilzomib in an NGLY1-dependent manner in U266, H929, and Jurkat cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer . WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC1=CC=C(C=C1)S(=O)(=O)C=CC(=O)NC(CCC2=CC=CC=C2)C(=O)NCCC(C)C
• IUPAC Name: (2S)-N-(3-methylbutyl)-2-[[(E)-3-(4-methylphenyl)sulfonylprop-2-enoyl]amino]-4-phenylbutanamide
• InChIKey: BLEQGDOEDLJWCG-NGIFANIDSA-N
• INCHI: 1S/C25H32N2O4S/c1-19(2)15-17-26-25(29)23(14-11-21-7-5-4-6-8-21)27-24(28)16-18-32(30,31)22-12-9-20(3)10-13-22/h4-10,12-13,16,18-19,23H,11,14-15,17H2,1-3H3,(H,26,29)(H,27,28)/b18-16+/t23-/m0/s1
• PubChem CID: 135300204

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (219.01 mM; Need ultrasonic)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2138924-36-2. InChIKey BLEQGDOEDLJWCG-NGIFANIDSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.