XY101 - 10mM in DMSO , CAS No.2349368-16-5

CAS: 2349368-16-5 Cat. No.: X656292 Molecular Weight: 563.48 PubChem CID: 138105957

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC 50 of 30 nM and a K d of 380 nM

In Vitro

XY101 potently inhibits cell growth, colony formation, and the expression of androgen receptor (AR), AR-V7 and prostate-specific antigen (PSA). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 30 nM (RORγ), Kd: 380 nM (RORγ)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC 50 of 30 nM and a K d of 380 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CCS(=O)(=O)C1=CC=C(C=C1)CC(=O)NC2=CC=C(C=C2)C3=C(C=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O)F
• PubChem CID: 138105957
• Molecular Weight: 563.48

Associated Targets(Human)

RORC Tchem Nuclear receptor ROR-gamma (0 Activities)

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)