≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Information
YUM70 is a potent inhibitor ofglucose-regulated protein 78 (GRP78)inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.
YUM70 is a potent inhibitor of glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
This compound belongs to the class of organic compounds known as hydroxyquinolines. These are compounds containing a quinoline moiety bearing a hydroxyl group.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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Reviews
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Application Protocols
No item-specific, tested application protocols are provided in the Product Data. The following generic protocols are offered as practical starting points for handling small-molecule research compounds; optimize as needed.
DMSO stock and aliquoting
Weigh compound quickly (minimize ambient exposure). Dissolve to 10–50 mM in anhydrous DMSO.
Vortex and, if necessary, sonicate briefly. Inspect for clarity; if hazy, reduce concentration or change solvent.
Dispense single-use aliquots (10–50 µL) in amber, low-bind tubes. Store at -20°C.
Aqueous working solutions
Prepare serial dilutions in DMSO to achieve convenient transfer volumes.
Add DMSO intermediate to pre-warmed buffer or media with vigorous mixing to reach the final test concentration. Keep final DMSO constant (e.g., 0.1–1%).
If precipitation occurs, lower final concentration, increase temperature slightly (≤37°C), or include compatible co-solvent/surfactant after control testing.
Analytical confirmation
Verify concentration by UV (if chromophore known) or LC–MS using an external standard.
Monitor stability over assay duration; re-make solutions if decomposition is detected.
Record-keeping
Document SKU, lot, preparation date, concentration, and solvent composition on each aliquot and in your ELN.
These are general recommendations; tailor to your biological or analytical assay.
Biological Roles
Item-specific biological targets or pathways are not provided in the Product Data. Do not infer activity without consulting primary literature tied to CAS 423145-35-1 and validating experimentally.
General considerations for small-molecule research compounds:
Potential roles: Such compounds may be explored as chemical probes in cell signaling, stress responses, metabolism, or protein–ligand interactions, depending on their structure and literature precedents (literature-dependent, not specified here).
Assay selection: Choose assays aligned to hypothesized mechanisms (e.g., enzyme inhibition, chaperone modulation, receptor binding), with orthogonal readouts to detect off-target or assay-interference effects.
ADME/physicochemical context: Solubility, lipophilicity, and chemical stability (none specified here) strongly influence cell permeability, nonspecific binding, and apparent potency; determine these empirically for your lot and conditions.
Counter-screens: Include redox, detergent, aggregation (e.g., detergent-sensitive activity, DLS), and pan-assay interference (PAINS) filters where applicable.
Important: This product is for research use only. No medical, diagnostic, or therapeutic claims are made or should be inferred from this catalog entry.
Buffer Applications
This material is not a buffering reagent. However, practical buffer-related guidance is often needed for preparing test solutions for biological assays.
General preparation guidance:
Vehicle: DMSO stocks are commonly diluted into physiological buffers (e.g., PBS, HBSS, assay-specific buffers). Keep final DMSO constant across all wells/samples (commonly 0.1–1% v/v).
Order of mixing: Add DMSO stock to buffer slowly with vigorous mixing to minimize precipitation. Pre-warm the buffer (25–37°C) if needed.
Surfactants: If aggregation is suspected, 0.01–0.05% nonionic surfactant (e.g., Tween 20) can help, provided it does not interfere with the assay.
Filtration: If particulate matter persists, sterile-filter through 0.22 µm PVDF/nylon only if compatible and if no adsorption losses are observed (run recovery checks by LC–MS/UV).
Buffer systems: Not applicable to this item; no intrinsic buffering capacity is claimed. Always validate compatibility with your biological readouts.
Green Alternatives
Because YUM70 is a discrete small molecule rather than a process solvent or bulk reagent, “green alternative” considerations primarily concern solvent and formulation choices during handling and assay preparation.
Greener handling options (general guidance):
Prefer DMSO or ethanol over DMF or NMP when feasible, balancing solubility and biological tolerance.
Use aqueous buffers with minimal organic cosolvent (≤0.5–1% v/v) where compatible with assay performance.
Minimize waste by preparing right-sized aliquots and adopting microscale screening formats.
Illustrative comparison (general):
DMSO vs DMF: DMSO offers comparable solvency with better biocompatibility and a more favorable EHS profile. DMF presents additional reproductive toxicity concerns and stricter waste handling.
Ethanol vs acetonitrile (for formulations): Ethanol is renewable and more biocompatible but provides weaker solvency; acetonitrile is petrochemical-derived and less tolerated biologically.
Operational sustainability tips:
Use amber vials and cold storage to extend shelf life and reduce material loss from degradation.
Implement closed, low-loss dispensing (positive-displacement tips, repeater pipettes) to limit solvent exposure and emissions.
Consolidate shipping with other cold-chain items to reduce packaging and transport footprint.
Pharmaceutical Uses
No pharmaceutical or clinical uses are claimed or supported for this catalog item. It is supplied strictly for research use only.
Context (general, non–item-specific):
Small molecules in discovery may be evaluated in pre-formulation studies (solubility, stability, excipient compatibility) purely for research. Such activities should not be construed as suitability for human or veterinary use.
Pharmacopeial status: Not specified for this item; it is not presented as a pharmacopeial-grade substance.
Excipient role: Not applicable; this product is not offered as an excipient.
If your work involves formulation research:
Characterize solubility across pH and cosolvent systems, assess stability (oxidative, hydrolytic, photolytic), and evaluate adsorption to plastics and filters.
Document all findings with lot numbers; do not extrapolate to clinical settings.
Physical Properties
Item-specific physicochemical data were not provided in the Product Data.
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Melting point: Not specified for this item; refer to CoA/Spec Sheet.
Boiling point: Not specified for this item; refer to CoA/Spec Sheet.
Density: Not specified for this item; refer to CoA/Spec Sheet.
Solubility: Not specified for this item; refer to CoA/Spec Sheet.
LogP/logD: Not specified for this item; refer to CoA/Spec Sheet.
pKa: Not specified for this item; refer to CoA/Spec Sheet.
Refractive index: Not applicable/unknown for solids; Not specified for this item; refer to CoA/Spec Sheet.
Small-molecule screening compounds are commonly supplied as solids or concentrated DMSO solutions. If supplied as a solid, initial dissolution in anhydrous DMSO (e.g., 10–50 mM) is a typical starting point; adjust per actual solubility (empirical testing recommended).
If hygroscopic or light-sensitive (status not specified here), minimize exposure to ambient humidity and light; use amber vials and desiccation.
Store at -20°C as specified to limit degradation and oxidative processes. Avoid repeated freeze–thaw by aliquoting stocks.
Always consult the CoA/SDS for definitive specifications and measured values for the specific lot purchased.
Quality and Grades
Grade/purity: Not specified for this item; refer to CoA/Spec Sheet.
Context and implications:
In small-molecule screening collections, materials are typically offered at research grade, suitable for discovery biology, in vitro assays, and method development. Absence of a stated “HPLC grade,” “bioactive grade,” or explicit purity threshold means end-users should verify suitability for their assay sensitivity and interference tolerance.
If purity is specified on the CoA (e.g., HPLC area %), consider potential co-eluting impurities that could confound phenotypic screens. Orthogonal purity checks (qNMR, LC–MS with UV and ELSD, HRMS) are recommended before critical studies.
Stabilizers: None are listed in the Product Data. If a stabilizer is present (e.g., BHT for oxidation-sensitive compounds), it will be declared on the CoA—evaluate its compatibility with your assay readout.
UV cutoff/fluorescence: Not specified. If using in optical assays, pre-screen compound absorbance/fluorescence to identify assay interference.
Documentation:
Request and review the lot-specific CoA and analytical package (chromatogram, MS, NMR) for definitive quality attributes.
For quantitative biology, run incoming quality control (identity, purity, water content by KF if relevant) to align with internal specifications.
Reaction and Applications
This product is cataloged as a small-molecule library compound for research; it is not primarily intended as a synthetic reagent. As such, classical organic reaction applications (e.g., as a catalyst, coupling partner, or solvent) are typically not applicable.
Relevant research applications (general, non–item-specific):
Chemical biology and discovery screening: Use as a test article in phenotypic or target-based assays after confirming identity/purity.
Mechanism-of-action studies: Suitable as a chemical probe candidate when supported by literature tied to the CAS. Validate activity in-house with orthogonal assays and counter-screens to rule out assay interference.
Biophysical binding: Evaluate with DSF, MST, ITC, or SPR as appropriate, controlling for solvent effects.
Practical tips:
Prepare concentrated DMSO stocks (e.g., 10 mM), aliquot, and minimize freeze–thaw. Verify solubility and stability by LC–MS over the assay timeframe.
Include vehicle controls and, where available, literature-referenced comparators linked to the same biological hypothesis (do not infer from this sheet; consult publications by CAS 423145-35-1).
Track batch/lot numbers rigorously in data records to ensure reproducibility across campaigns.
Reaction Conditions
Classical reaction condition guidance is not directly applicable because this product is not offered as a reagent for performing chemical transformations. Instead, the following outlines common conditions for preparing and using small-molecule test articles in in vitro experiments (general guidance):
Stock preparation: Dissolve in anhydrous DMSO to 10 mM (or as solubility permits). Confirm solution clarity and stability by LC–MS/UV after 0, 24, and 72 h at room temperature and 4°C.
Working concentrations: Determine empirically; many cell-based assays explore 0.01–50 µM ranges with serial dilutions. Include a consistent vehicle control.
Temperature: Prepare and store stocks at -20°C; perform dilutions at room temperature unless the assay requires otherwise. Avoid >37°C exposure unless solubility screening demands brief warming.
Light/oxygen: If the compound is suspected to be light- or air-sensitive (not specified), prepare and store under reduced light and inert headspace where practical.
Materials compatibility: Use glass or low-bind plastics to reduce adsorption losses; pre-rinse tips/vials with dilute working solution when quantitation is critical.
These are general, literature-informed practices. Always adapt to your assay system and verify compatibility and stability experimentally.
Safety and Handling
GHS/CLP details for this specific item were not provided in the Product Data.
Signal word: Not specified for this item; refer to SDS.
Hazard statements (H-phrases): Not specified for this item; refer to SDS.
GHS classification and pictograms: Not specified for this item; refer to SDS.
General laboratory safety guidance (always defer to the SDS for authoritative information):
Engineering controls: Work in a certified chemical fume hood when weighing powders or preparing solutions to avoid inhalation exposure.
PPE: Lab coat, safety glasses, and appropriate chemically resistant gloves (e.g., nitrile). Change gloves regularly when handling DMSO or other strong solvents.
Incompatibilities: Unknown for this specific molecule; as a precaution, avoid strong oxidizers and strong acids/bases until compatibility is confirmed (general practice for organic small molecules).
First aid (overview): If skin contact occurs, wash with soap and water. If eye contact occurs, rinse cautiously with water for several minutes and seek medical attention. If inhaled or ingested, follow institutional emergency procedures and consult the SDS.
Spill/cleanup: Avoid dust generation; absorb solutions with inert material and dispose of as hazardous chemical waste per local regulations.
Waste: Collect in properly labeled organic waste streams. Do not dispose to drain.
Note: This product is for research use only.
Solvent Selection
This item’s specific solubility profile is not provided. The following solvent strategy is general guidance for small organic research compounds; empirical testing is advised.
Primary stock solvent (typical): Anhydrous DMSO, targeting 10–50 mM stocks. Confirm solubility visually and by LC–MS.
Secondary solvents for co-solvation or formulation screens: DMF, ethanol, methanol, acetonitrile. Combine with aqueous buffers (e.g., PBS, HBSS) to reach desired final solvent fraction in assays.
Aqueous compatibility: Many hydrophobic compounds require ≤0.5–1% v/v DMSO in final assays to maintain cell health; determine tolerability for your system.
Polarity class (general): Unknown for this item; treat as an organic, non-volatile small molecule pending structural confirmation.
Practical selection tips:
Begin with DMSO. If precipitation occurs upon dilution into aqueous media, pre-warm buffer (25–37°C), add slowly with vortexing, and keep final organic fraction consistent across controls.
For biophysical assays (SPR/DSF), match solvent composition in sample and reference channels to minimize baseline drift.
Avoid adsorptive losses by using low-bind plastics or glass and adding carrier proteins (e.g., 0.01–0.1% BSA) only if compatible with the assay.
Comparison (general considerations):
DMSO: Broad solvency, low volatility; may affect enzyme kinetics at >1–2%.
Ethanol: Volatile, biologically tolerated at ≤0.5–1%; lower solvency vs DMSO.
DMF: Strong solvency; consider toxicity and disposal constraints.
Acetonitrile: Useful for HPLC and some assays; limited biocompatibility at modest %.
Solvent: If supplied as a solid, reconstitute in anhydrous DMSO to prepare a concentrated stock (e.g., 10–50 mM), then aliquot. If supplied as a solution, verify concentration and consider sub-aliquoting upon receipt.
Light/moisture: In absence of item-specific data, protect from light and moisture. Use amber vials and a desiccant in secondary containment.
Equilibration: Allow container to warm to room temperature in a desiccator before opening to prevent condensation.
Handling and storage tips:
Aliquot to minimize freeze–thaw cycles; repeated thawing can accelerate degradation.
Headspace: If long-term storage is planned, consider inert gas backfill (N2/Ar) after opening.
Stability/shelf life: Not specified for this item; refer to CoA/Spec Sheet. Verify integrity periodically by LC–MS/HPLC.
Disposal: Dispose of unused solutions and contaminated materials as organic chemical waste according to institutional and local regulations.
Research use only: Not for human or veterinary use.
Structure and Identity
Brief overview: YUM70 is listed in our small-molecule library category. Limited structure identifiers are provided for this specific catalog item; consult primary literature and the CoA/SDS for full structural details.
SKU: Y413413
Product name: YUM70
CAS: 423145-35-1 (as provided)
PubChem CID: 3138755 (as provided)
InChIKey: 25861 (as provided)
SMILES: Not specified for this item; refer to CoA/Spec Sheet.
Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
Structural features (general notes):
Specific functional groups, stereochemistry, and ring systems are not listed in the Product Data. Refer to authoritative databases using the CAS or CID to confirm structural motifs (literature/third-party resources).
2D structure description: Not specified for this item; refer to CoA/Spec Sheet.
Identity verification guidance (general):
Confirm identity via orthogonal methods (HRMS, 1H/13C NMR, and, if chiral, optical rotation or chiral HPLC).
Match spectral data against peer-reviewed references indexed to CAS 423145-35-1 (literature).
Synthetic Utility
This catalog entry is a small-molecule research compound and is not primarily intended as a synthetic building block or reagent. Therefore, direct synthetic applications (e.g., as a coupling partner, catalyst, or protecting group reagent) are typically not applicable.
General notes (if pursuing custom synthesis or derivatization):
Consult peer-reviewed literature indexed to CAS 423145-35-1 for any reported syntheses, intermediates, or structure–activity relationship (SAR) derivatives (literature-dependent; not specified here).
If derivatization is desired (e.g., biotinylation, photoaffinity tags), confirm functional handles in the structure (not provided here) and evaluate stability of putative reactive sites under coupling conditions.
For analytical support, develop LC–MS and NMR methods to track conversions and impurity profiles; use orthogonal detection (UV + MS + ELSD) if the chromophore is weak or unknown.
Bottom line: Treat this item as a test article rather than a reagent, unless literature for the specific CAS indicates otherwise.
Target Specificity
Target, epitope, clone, isotype, species reactivity, and similar attributes are not applicable to this small-molecule item. No target specificity information is provided in the Product Data for YUM70.
Target name: Not specified for this item; refer to CoA/Spec Sheet and peer-reviewed literature linked to CAS 423145-35-1.
Mechanism of action: Not specified for this item; consult literature and validate in-house.
Note: Do not infer biological targets from the catalog name alone. Establish specificity using orthogonal biochemical and biophysical assays.
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Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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