GRADE & PURITYBioReagent?BioReagent grade — tested suitable for life-science and molecular-biology use. Use for cell culture, assays, and biochemical work needing biological compatibility.≥98%
Synonyms
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-AFC | Caspase-3 Substrate IV, Fluorogenic
Storage
Protected from light,Store at -20°C,Desiccated,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Application
Apoptosis, Cell signaling, Drug screening, Enzyme activity assay
BioReagent, ≥98% BioReagent for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Protected from light,Store at -20°C,Desiccated,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Z-DEVD-AFC is a synthetic polypeptide whose core part consists of four amino acids: Asp-Glu-Val-Asp (DEVD), linked to a fluorophore AFC (7-amino-4-trifluoromethylcoumarin). During the process of cell apoptosis, especially when some caspases are activated, Z-DEVD-AFC will be cleaved to release AFC, which emits bright fluorescence and acts as a real-time monitor of the apoptotic process.
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity.
Specifications
Synonyms
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-AFC | Caspase-3 Substrate IV, Fluorogenic
Specifications & Purity
BioReagent, ≥98%
Biochemical and Physiological Mechanisms
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity.
Stability And Storage
Store at -20℃ long term (24 months). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle. Store in the dark. Desiccated.
Storage
Protected from light, Store at -20°C, Desiccated, Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
BioReagent
Purity
≥98%
Names and Identifiers
Alternate CAS
1177935-21-5
Molecular Weight
821.7
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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