20-COOH-LTB4 - ≥97%, 100 μg/ml in ethanol , CAS No.80434-82-8

CAS: 80434-82-8 Cat. No.: C353436 Formule: C₂₀H₃₀O₆ Poids moléculaire: 366.45 Numéro CE: 632-880-2 PubChem CID: 5280877

GRADE & PURITY ≥97%, 100 μg/ml in ethanol

Synonyms

BML1-E06 | HY-113483 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioate | 20-carboxyleukotriene B4 | 20-Carboxy-leukotriene B4 | 20-Carboxy-leukotriene- B4 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioic acid | C059

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

20-COOH-LTB|4|is an ω-oxidized metabolite of leukotriene B|4|. Leukotrienes have been shown to be potent eicosanoid lipid mediators derived from phospholipase-released Arachidonic Acid . These compounds have been reported to be involved in inflammation and numerous homeostatic biological functions. In rat hepatocytes, 20-COOH-LTB|4|is noted to be a substrate for β-oxidation pathways found in peroxisomes and mitochondria.

Specifications

Synonymes

BML1-E06 | HY-113483 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioate | 20-carboxyleukotriene B4 | 20-Carboxy-leukotriene B4 | 20-Carboxy-leukotriene- B4 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioic acid | C059

Spécifications et pureté

≥97%, 100 μg/ml in ethanol

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥97%

Propriétés du produit

pKa

pKa: 4.66

Noms et identifiants

Sourires canoniques

C(CCC(=O)O)CC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O

IUPAC Name

(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenedioic acid

InChIKey

SXWGPVJGNOLNHT-VFLUTPEKSA-N

INCHI

1S/C20H30O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-18,21-22H,1,3,9-11,14-16H2,(H,23,24)(H,25,26)/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m1/s1

Isomères SMILES

C(CCC(=O)O)C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O

WGK Allemagne

3

PubChem CID

5280877

Poids moléculaire

366.45

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Classe Fatty Acyls
      • Subclass Fatty acids and conjugates

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Classe: Fatty Acyls
• Subclass: Fatty acids and conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Long-chain fatty acids
• Alternative Parents: Hydroxy fatty acids Unsaturated fatty acids Dicarboxylic acids and derivatives Secondary alcohols Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Long-chain fatty acid - Hydroxy fatty acid - Unsaturated fatty acid - Dicarboxylic acid or derivatives - Secondary alcohol - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.
• External Descriptors: Leukotrienes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in water, ethanol, DMF, DMSO, and PBS pH 7.2.
• Indice de réfraction: n20D1.55
• Point d'éclair (°F): 57.2 °F
• Point d'éclair (°C): 14 °C
• Point d'ébullition (°C): 78° C
• Poids moléculaire: 366.400 g/mol
• XLogP3: 2.400
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 15
• Exact Mass: 366.204 Da
• Monoisotopic Mass: 366.204 Da
• Topological Polar Surface Area: 115.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 504.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 4
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 4
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 80434-82-8, the molecular formula is C20H30O6, and the molecular weight is 366.45 g/mol. InChIKey SXWGPVJGNOLNHT-VFLUTPEKSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.