≥95%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
product describtion:
A cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50<1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases, including PI-3 Kinase (60% inhibition at 10 µM). Effectively inhibits Akt-mediated cellular GSK3β Ser9 and mTOR Ser2448 phosphorylation (4 µM in HCT116 cultures) in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth by 50% when administered at an oral dosage of 30 mg/kg in mice (5 times/wk for 3 wks) in vivo.
| Canonical Smiles | C1=CC=C2C(=C1)C(=CN2)C(=O)CCl |
|---|---|
| IUPAC Name | 2-chloro-1-(1H-indol-3-yl)ethanone |
| InChIKey | LLZQFAXTCYDVTR-UHFFFAOYSA-N |
| INCHI | 1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2 |
| Isomeric SMILES | C1=CC=C2C(=C1)C(=CN2)C(=O)CCl |
| WGK Germany | 3 |
| Molecular Weight | 193.63 |
| Reaxy-Rn | 142045 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=142045&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Indoles and derivatives |
| Subclass | Indoles |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Indoles |
| Alternative Parents | Aryl alkyl ketones Substituted pyrroles Benzenoids Vinylogous amides Heteroaromatic compounds Alpha-chloroketones Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Alkyl chlorides |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Indole - Aryl alkyl ketone - Aryl ketone - Substituted pyrrole - Benzenoid - Alpha-haloketone - Alpha-chloroketone - Pyrrole - Heteroaromatic compound - Vinylogous amide - Ketone - Azacycle - Alkyl chloride - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Alkyl halide - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G2403374 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403375 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403376 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403377 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403378 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403379 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403380 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403381 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403382 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403383 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403405 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403406 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403407 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| G2403408 | Certificate of Analysis | Apr 25, 2024 | C169278 |
| Solubility | DMSO: 100 mg/mL |
|---|---|
| Sensitivity | light sensitive |
| Molecular Weight | 193.630 g/mol |
| XLogP3 | 2.700 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 2 |
| Exact Mass | 193.029 Da |
| Monoisotopic Mass | 193.029 Da |
| Topological Polar Surface Area | 32.900 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 207.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
