8-OH-DPAT - Moligand™, ≥97% , Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Agonist of 5-HT 1D receptor;Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor;Agonist of 5-HT 2A receptor;Agonist of 5-HT 2B receptor;Agonist of 5-HT 2C receptor;A, Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Agonist of 5-HT 1D receptor;Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor;Agonist of 5-HT 2A receptor;Agonist of 5-HT 2B receptor;Agonist of 5-HT 2C receptor;Agonist of 5-HT 5A receptor;Ago

CAS: 78950-78-4 Cat. No.: O414014 Formule: C₁₆H₂₅NO Poids moléculaire: 247.19

QUALITÉ & PURETÉ Moligand™, ≥97%

Synonyms

CCG-204665 | DPAT | 8-hydroxy-n,n-dipropyl-2-aminotetralin | (R)-8-Hydroxy-2-dipropylaminotetralin | Q4644282 | 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol | DTXSID30897384 | [3H]-8-OH-DPAT | [3H]8-OH-DPAT | EX-A2914 | 8-HYDROXY-2-(DI-n-PROPYLAMIN

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Information

8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic5-HT1Aagonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.

Targets

5-HT1A (Cell-free) 8.19(pIC50)

In vitro

The drug is only weakly effective at 5-HT1B subtype, the pIC50 being 5.42 ± 0.08 (n = 5). Since 8-OH-DPAT has no effect on 5-HT1B binding at concentrations lower than 100 nM. 8-OH-DPAT is able to reduce the accumulation of both autophagic-derived and photoreceptor outer segment-derived lipofuscin, increase antioxidant protection and reduce oxidative damage in cultured human RPE cells.

In vivo

Intravenous administration of the selective 5-HT1A-receptor agonist 8-OH-DPAT rapidly reverses the hypotensive and bradycardic responses established during severe hemorrhage with relatively little variability. 8-OH-DPAT is relatively lipophilic and readily crosses the blood-brain barrier.

Cell Research(from reference)

Cell lines：Retinal pigment epithelial (RPE) cells 

Concentrations：10 μM 

Incubation Time：24 h 

Spécifications

Synonymes

CCG-204665 | DPAT | 8-hydroxy-n,n-dipropyl-2-aminotetralin | (R)-8-Hydroxy-2-dipropylaminotetralin | Q4644282 | 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol | DTXSID30897384 | [3H]-8-OH-DPAT | [3H]8-OH-DPAT | EX-A2914 | 8-HYDROXY-2-(DI-n-PROPYLAMIN

Spécifications et pureté

Moligand™, ≥97%

Mécanismes biochimiques et physiologiques

8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic 5-HT1A agonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

AGONIST

Mécanisme d'action

Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Agonist of 5-HT 1D receptor;Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor;Agonist of 5-HT 2A receptor;Agonist of 5-HT 2B receptor;Agonist of 5-HT 2C receptor;Agonist of 5-HT 5A receptor;Ago

Pureté

≥97%

Noms et identifiants

Pubchem Sid

528762913

Sourires canoniques

CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O

IUPAC Name

7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol

InChIKey

ASXGJMSKWNBENU-UHFFFAOYSA-N

INCHI

1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3

Isomères SMILES

CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O

CAS alternatif

78950-78-4

Termes d'entrée MeSH

8-Hydroxy-2-(di-n-propylamino)tetralin;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (+-)-Isomer;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (R)-Isomer,;8-Hydroxy-2-(di-n-propylamino)tetr

Poids moléculaire

247.19

Reaxy-Rn

3546291

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3546291&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Tetralins

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Tetralins
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Tetralins
• Alternative Parents: Aralkylamines 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Trialkylamines Organopnictogen compounds Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Tetralin - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Tertiary aliphatic amine - Tertiary amine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as tetralins. These are polycyclic aromatic compounds containing a tetralin moiety, which consists of a benzene fused to a cyclohexane.
• External Descriptors: tertiary amino compound - phenols - tetralins

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro DMSO: 49 mg/mL (198.07 mM); Ethanol: 49 mg/mL (198.07 mM); Water: Insoluble
• Poids moléculaire: 247.380 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 247.194 Da
• Monoisotopic Mass: 247.194 Da
• Topological Polar Surface Area: 23.500 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 237.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1