ABBV-744 - Moligand™, 10mM in DMSO , CAS No.2138861-99-9

CAS: 2138861-99-9 Cat. No.: A409120 Formule: C₂₈H₃₀FN₃O₄ Poids moléculaire: 491.55

QUALITÉ & PURETÉ Moligand™, 10mM in DMSO

Synonyms

1H-​Pyrrolo[2,​3-​c]​pyridine-​2-​carboxamide, N-​ethyl-​4-​[2-​(4-​fluoro-​2,​6-​dimethylphenoxy)​-​5-​(1-​hydroxy-​1-​methylethyl)​phenyl]​-​6,​7-​dihydro-​6-​methyl-​7-​oxo-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

ABBV-744 ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.
In vitro

ABBV-744 is a potent inhibitor specific for BDII of BRD2/3/4, with >250-fold differential binding preference for BDII over BDI and excellent drug-like properties. ABBV-744 is also a potent and selective inhibitor of the AR (androgen receptor) transcription pathway.

In vivo

In vivo, doses of ABBV-744 at fractions of its maximum tolerated dose (MTD) induces tumor growth inhibition in AML and prostate cancer xenograft models that were comparable to those observed with ABBV-075 when dosed at its MTD.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Spécifications

Synonymes

1H-​Pyrrolo[2,​3-​c]​pyridine-​2-​carboxamide, N-​ethyl-​4-​[2-​(4-​fluoro-​2,​6-​dimethylphenoxy)​-​5-​(1-​hydroxy-​1-​methylethyl)​phenyl]​-​6,​7-​dihydro-​6-​methyl-​7-​oxo-

Spécifications et pureté

Moligand™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Propriétés du produit

ALogP

4.36

hba_count

3

Nombre de HBD

2

Liaison rotative

6

Noms et identifiants

Isomères SMILES

CCNC(=O)C1=CC2=C(N1)C(=O)N(C=C2C3=C(C=CC(=C3)C(C)(C)O)OC4=C(C=C(C=C4C)F)C)C

Poids moléculaire

491.55

Reaxy-Rn

31981858

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31981858&ln=

Cibles associées (humaines)

BRD4 Tchem Bromodomain-containing protein 4 (5 Activities)

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRDT Tchem Bromodomain testis-specific protein (2 Activities)

Discover Target: BRDT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD3 Tchem Bromodomain-containing protein 3 (1 Activities)

Discover Target: BRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD2 Tchem Bromodomain-containing protein 2 (1 Activities)

Discover Target: BRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• DMSO (mg/mL) Solubilité maximale: 98
• DMSO (mM) Solubilité maximale: 199.369341877734
• Eau (mg/mL) Solubilité maximale: ＜1

Foire aux questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2138861-99-9, the molecular formula is C28H30FN3O4, and the molecular weight is 491.55 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.