AF38469 - 10mM in DMSO , CAS No.1531634-31-7

CAS: 1531634-31-7 Cat. No.: A655208 Formule: C₁₅H₁₁F₃N₂O₃ Poids moléculaire: 324.25 PubChem CID: 72706115

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC 50 value of 330 nM.

In Vivo

AF38469 (1 mg/kg; i.v.) has a low volume of distribution (blood volume of 0.7 L/kg) and low clearance (4.8 L/h/kg), and a half-life (t1/2) of 1.2 h in rat . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50:330 nM (Sortilin)

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC 50 value of 330 nM.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

• Isomères SMILES: CC1=NC(=CC=C1)NC(=O)C2=C(C=C(C=C2)C(F)(F)F)C(=O)O
• PubChem CID: 72706115
• Termes d'entrée MeSH: AF38469
• Poids moléculaire: 324.25

Cibles associées (humaines)

SORT1 Tchem Sortilin (2 Activities)

Discover Target: SORT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)