10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Aloin Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
In vitro
Aloin, a natural anthracycline from Aloe vera, is a tyrosinase inhibitor with inhibitory rates of 2mM. Aloin shows a pronounced antiproliferative effect at physiological concentration (IC50 = 97 μM), causes cell cycle arrest in the S phase and markedly increases HeLaS3 cell apoptosis (to 24%). Aloin causes a reduction in the proportion of cells undergoing mitosis by induction of apoptosis, inhibition of topo II alpha protein expression and downregulation of cyclin B1 protein expression in MCF-7 cell line.
In vivo
Cell Data
cell lines：HF1A3, HF4.9 and HF28RA cells
Concentrations：
Incubation Time：
Powder Purity:≥98%
| Isomeric SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C([C@H]2[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C=C(C=C3O)CO |
|---|---|
| WGK Germany | 3 |
| RTECS | LZ6520000 |
| Molecular Weight | 418.39 |
| Beilstein | 6077558 |
| Reaxy-Rn | 25113924 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25113924&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 177 mg/mL (199.94 mM); Water: 177 mg/mL (199.94 mM); Ethanol: 177 mg/mL (199.94 mM); |
|---|---|
| Melt Point(°C) | 148-149°C |
| 1. Xiaozhang Ying, Congcong Yu, Wentao Yang, Lin Ye, Rongtai Sun, Tianyuan Gu, Shunwu Fan, Shasha Yao. (2023) The transformation of multifunctional bio-patch to hydrogel on skin wounds for efficient scarless wound healing. Materials Today Bio, [PMID:38188643] [10.1016/j.mtbio.2023.100901] |
| 2. Zhi-feng Cai, Chen-hua Deng, Jiao Wang, Yao Zuo, Jing-long Wu, Xiao-peng Wang, Tian-zhi Lv, Yuan-yuan Wang, Deng-yun Feng, Jie Zhao, Cai-feng Zhang, Ji-ming Zhang. (2021) Sensitive and selective determination of aloin with highly stable histidine-capped silver nanoclusters based on the inner filter effect. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [PMID:] [10.1016/j.colsurfa.2021.127224] |
| 3. Qinrun Lai, Hong Wang, Xinbo Guo, Arshad Mehmood Abbasi, Taixia Wang, Tong Li, Xiong Fu, Jingyuan Li, Rui Hai Liu. (2016) Comparison of phytochemical profiles, antioxidant and cellular antioxidant activities of seven cultivars of Aloe. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 51 (6): (1489-1494). [PMID:] [10.1111/ijfs.13093] |
| 4. Xin-Yu Xiao, Qian-Wei Luo, Wang-Shu Li, Ze-Kun Chen, Zhuo Yang, Ya-Xuan Zhu, Mu-Rong Lei, Fang-Fang Zhuo, Ming Yu, Tian-Tian Wei, Hong-Wei Jin, Zhong-Yao Li, Zhi-Yuan Lu, Zhu-Qing Zhang, Hua Wang, Yong-Cheng Wang, Qing Xia, Wei Yu, Bo Han, Peng-Fei Tu, Ke-Wu Zeng. (2025) Nanoparticles Induce Protein Corona Conformational Change to Reshape Intracellular Interactome for Microglial Polarization. ACS Nano, [PMID:40913578] [10.1021/acsnano.5c12630] |
| 5. Shen Zhang, Meiqi Bai, Jing Qian, Yuyu Guo. (2021) Water-soluble luminescent gold nanoclusters reduced and protected by histidine for sensing of barbaloin and temperature. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2021.106564] |
