Amisulpride - Moligand™, 10mM in DMSO , Dopamine receptors; D2 & D3 antagonist, CAS No.71675-85-9, Dopamine receptors; D2 & D3 antagonist

CAS: 71675-85-9 Cat. No.: A408070 Molecular Weight: 369.48 EC Number: 275-831-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

DAN-2163 | 4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

DAN-2163 | 4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Dopamine receptors; D2 & D3 antagonist

Product Properties

• ALogP: 1.5

Names and Identifiers

• Isomeric SMILES: CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC
• WGK Germany: 3
• RTECS: CV2308701
• Molecular Weight: 369.48
• Reaxy-Rn: 6876191
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6876191&ln=

Associated Targets(Human)

DRD2 Tclin D(2) dopamine receptor (3 Activities)

Discover Target: DRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor (2 Activities)

Discover Target: DRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR7 Tclin 5-hydroxytryptamine receptor 7 (1 Activities)

Discover Target: HTR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro Water: 36 mg/mL (200.84 mM); DMSO: Insoluble; Ethanol: Insoluble
• Melt Point(°C): 127 °C

References

1. Huanhuan Yang, Cong Liu, Chuanhong Zhu, Yan Zheng, Juan Li, Qianyun Zhu, Hao Wang, Xiangming Fang, Quan Liu, Man Liang, Zilong Liu.  (2023)  Determination of ten antipsychotics in blood, hair and nails: Validation of a LC–MS/MS method and forensic application of keratinized matrix analysis.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:37406464] [10.1016/j.jpba.2023.115557]

2. Junlei He, Jiahao Yuan, Juan Du, Xiaoguang Chen, Xinguo Zhang, Ande Ma, Jialiang Pan.  (2018)  Automated on-line SPE determination of amisulpride in human plasma using LC coupled with restricted-access media column.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2018.10.029]

3. Wen-Peng Zhang, Dong-Ying Chen.  (2017)  Crystal structures and physicochemical properties of amisulpride polymorphs.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:28371719] [10.1016/j.jpba.2017.03.030]