Ampicilline Na - pour la culture cellulaire , CAS No.69-52-3

CAS: 69-52-3 Cat. No.: A105484 Formule: C₁₆H₁₈N₃NaO₄S Poids moléculaire: 371.39 Numéro CE: 200-708-1

GRADE & PURITY for Cell culture

Synonyms

AMPICILLIN SODIUM (MONOGRAPHIE USP) | (2S,5R,6R)-6-{[(2R)-2-amino-2-phénylacétyl]amino}-3,3-diméthyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | A836527 | Ampicilline (sous forme de sodium) | AMPICILLINE SODIUM [LIVRE VERT] | D-(-)-alpha-Amino

Storage

A conserver entre 2 et 8°C

Shipped In

Glace humide

Vue d’ensemble

L'ampicilline est légèrement soluble dans l'eau, pratiquement insoluble dans l'alcool, le chloroforme, l'éther et les huiles fixes, mais soluble dans les acides ou les bases dilués. La solution ne doit pas être stérilisée à l'autoclave ; une solution mère doit être stérilisée par filtration et conservée à l'état congelé, où elle sera stable pendant des mois.
Utilisé pour sélectionner la résistance à l'ampicilline dans les cellules mutées et transformées.

Specifications

Synonymes

AMPICILLIN SODIUM (MONOGRAPHIE USP) | (2S,5R,6R)-6-{[(2R)-2-amino-2-phénylacétyl]amino}-3,3-diméthyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | A836527 | Ampicilline (sous forme de sodium) | AMPICILLINE SODIUM [LIVRE VERT] | D-(-)-alpha-Amino

Spécifications et pureté

pour la culture cellulaire

Mécanismes biochimiques et physiologiques

Mode d'action : Il s'agit d'un antibiotique β-lactame qui inhibe la synthèse de la paroi cellulaire bactérienne en inactivant les transpeptidases sur la surface interne de la membrane cellulaire bactérienne. Mode de résistance : L'administration avec une

Conditions de stockage de stockage

A conserver entre 2 et 8°C

Expédié en

Glace humide

Grade

for Cell culture

Noms et identifiants

Pubchem Sid

504769486

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504769486

Sourires canoniques

CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)[O-])C.[Na+]

IUPAC Name

sodium;(2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

InChIKey

KLOHDWPABZXLGI-YWUHCJSESA-M

INCHI

1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

Isomères SMILES

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)C(=O)[O-])C.[Na+]

Poids moléculaire

371.39

Reaxy-Rn

1231014

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1231014&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 N-acyl-alpha amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: N-acyl-alpha amino acids and derivatives
• Alternative Parents: Penams Aralkylamines Benzene and substituted derivatives Thiazolidines Tertiary carboxylic acid amides Amino acids Azetidines Thiohemiaminal derivatives Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Monocarboxylic acids and derivatives Carboximidic acids Dialkylthioethers Carboxylic acids Hydrocarbon derivatives Carbonyl compounds Monoalkylamines Organic oxides Organic sodium salts Organic zwitterions Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-acyl-alpha amino acid or derivatives - Penam - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Beta-lactam - Tertiary carboxylic acid amide - Thiazolidine - Azetidine - Carboxamide group - Amino acid - Lactam - Carboximidic acid - Carboximidic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Azacycle - Organic alkali metal salt - Organoheterocyclic compound - Thioether - Hemithioaminal - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Dialkylthioether - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Carbonyl group - Primary amine - Organic sodium salt - Amine - Organic oxide - Organic zwitterion - Organic salt - Organic nitrogen compound - Hydrocarbon derivative - Primary aliphatic amine - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom.
• External Descriptors: organic sodium salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: H2O: soluble50 mg/mL
• Point de fusion (°C): 215°C
• Poids moléculaire: 371.400 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 371.092 Da
• Monoisotopic Mass: 371.092 Da
• Topological Polar Surface Area: 141.000 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 568.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3