BIS-TRIS - Anhydrous Grade, ≥98% , CAS No.6976-37-0

CAS: 6976-37-0 Cat. No.: B433343 Molecular Weight: 209.24 Beilstein Registry Number: 2205275 EC Number: 686-880-2

GRADE & PURITY Anhydrous Grade, ≥98%

Synonyms

1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- | 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol | Bis(2-hydroxyethyl)iminotris(hydroxymethyl)methane BIS-TRIS | Bistris; NSC 119932; NSC 24868; NuPage Bis-Tris | NSC24868 |

Storage

Room temperature

Specifications

Synonyms

1, 3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- | 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1, 3-diol | Bis(2-hydroxyethyl)iminotris(hydroxymethyl)methane BIS-TRIS | Bistris; NSC 119932; NSC 24868; NuPage Bis-Tris | NSC24868 |

Specifications & Purity

Anhydrous Grade, ≥98%

Storage

Room temperature

Grade

Anhydrous Grade

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C(CO)N(CCO)C(CO)(CO)CO
• IUPAC Name: 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
• InChIKey: OWMVSZAMULFTJU-UHFFFAOYSA-N
• INCHI: 1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2
• Isomeric SMILES: C(CO)N(CCO)C(CO)(CO)CO
• WGK Germany: 3
• Molecular Weight: 209.24
• Beilstein: 2205275
• Reaxy-Rn: 2205275
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2205275&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Amines
        • Level5 Alkanolamines
          • Level6 1,2-aminoalcohols

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Alkanolamines
• Direct Parent: 1,2-aminoalcohols
• Alternative Parents: Trialkylamines Primary alcohols Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Tertiary aliphatic amine - Tertiary amine - 1,2-aminoalcohol - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Alcohol - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.
• External Descriptors: pentol

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: water: 500mg/mL, clear, colorless to faint yellow or tan
• Melt Point(°C): 103-104°C
• Molecular Weight: 209.240 g/mol
• XLogP3: -3.300
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 209.126 Da
• Monoisotopic Mass: 209.126 Da
• Topological Polar Surface Area: 104.000 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 125.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Hui Yang, Yingying Hou, Yujie Pan, Tingting Zhang, Qi Meng, Jianzhong Han, Weilin Liu, Daofeng Qu.  (2023)  Effect of chewing ability on in vivo oral digestive characteristics and in vitro gastrointestinal starch hydrolysis of three different types of cooked rice.  Food & Function,  14  (20): (9324-9336).  [PMID:37781893] [10.1039/D3FO02225K]

2. Pengzhi Li, Xutao Zhang, Qi Yang, Pengjian Gong, Chul B. Park, Guangxian Li.  (2023)  Sustainable polyester vitrimer capable of fast self-healing and multiple shape-programming via efficient synthesis and configuration processing.  Journal of Materials Chemistry A,  11  (20): (10912-10926).  [PMID:] [10.1039/D3TA00302G]

3. Wenjuan Huang, Liwen Wang, Ruhui Yang, Ronggui Hu, Qinxiang Zheng, Xingjie Zan.  (2022)  Combined delivery of small molecule and protein drugs as synergistic therapeutics for treating corneal neovascularization by a one-pot coassembly strategy.  Materials Today Bio,      [PMID:36281304] [10.1016/j.mtbio.2022.100456]

4. Pengzhi Li, Bin Lan, Xutao Zhang, Siyuan Lei, Qi Yang, Pengjian Gong, Chul B. Park, Guangxian Li.  (2022)  Facile in situ construction of a covalent adaptable network polyester vitrimer with advanced performance in repairability, foamability and recyclability.  GREEN CHEMISTRY,  24  (14): (5490-5501).  [PMID:] [10.1039/D2GC01320G]

5. Pengyan Hao, Xiaoxiao Wu, Liwen Wang, Shaoyin Wei, Hongyan Xu, Wenjuan Huang, Yana Li, Tinghong Zhang, Xingjie Zan.  (2020)  One-Pot Generating Subunit Vaccine with High Encapsulating Efficiency and Fast Lysosome Escape for Potent Cellular Immune Response.  BIOCONJUGATE CHEMISTRY,      [PMID:32639141] [10.1021/acs.bioconjchem.0c00274]

6. Tinghong Zhang, Long Zhang, Xiaoxiao Wu, Hongyan Xu, Pengyan Hao, Wenjuan Huang, Yagang Zhang, Xingjie Zan.  (2020)  Hexahistidine–Metal Assemblies: A Facile and Effective Codelivery System of Subunit Vaccines for Potent Humoral and Cellular Immune Responses.  MOLECULAR PHARMACEUTICS,      [PMID:32469222] [10.1021/acs.molpharmaceut.0c00212]

7. Changyun Quan, Yue Zhang, Yuanyuan Liu, Liping Wen, Haixia Yang, Xueqin Huang, Minghui Yang, Binjie Xu.  (2024)  Electrochemical Glucose Sensor Based on Dual Redox Mediators.  Biosensors-Basel,  15  (1): (9).  [PMID:39852060] [10.3390/bios15010009]

8. Xianjiang Ye, Ran Yang, Zhizhi Yang, Baote Huang, Talha Riaz, Chao Zhao, Jicheng Chen.  (2025)  Novel angiotensin-I-converting enzyme (ACE) inhibitory peptides from Porphyra haitanensis: Screening, digestion stability, and mechanistic insights.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106460]

9. De-Zhuang Jia, Lei Li, Yang Yang, Jie Zhang, Tai-Bao Yang, Hao Lin, Hua-Dong Huang, Gan-Ji Zhong, Zhong-Ming Li.  (2025)  Recycling Thermoplastic Polyester with Dynamic Covalent Networks.  MACROMOLECULES,      [PMID:] [10.1021/acs.macromol.5c01764]

10. Weiqiang Han, Xia Liao.  (2025)  Enhanced Interfacial Compatibility Induced by Two-Step Reactive Extrusion: Toward Simultaneously Strengthening Mechanical and Foaming Properties of PEF/PGA Blends.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.5c03094]

11. Chenbo Liao, Qingkai Xu, Chaolumen Wu, Daling Fang, Shengyang Chen, Shimou Chen, Jiangshui Luo, Lei Li.  (2016)  Core–shell nano-structured carbon composites based on tannic acid for lithium-ion batteries.  Journal of Materials Chemistry A,  4  (43): (17215-17224).  [PMID:] [10.1039/C6TA07359J]

12. Weiqiang Han, Xia Liao.  (2025)  Construction of biobased PEF/PTMC composite vitrimer with advanced performance in mechanical properties, reprocessability and foamability via catalyst-free method.  Applied Materials Today,      [PMID:] [10.1016/j.apmt.2025.102668]

13. Xiaohai He, Bo Gao, Qingyuan Wu, Chengrui Xin, Junjie Xue, Fangwei Lu, Xin-Ping Qu, Simin Li, Fan Zhang, Hui Shen.  (2025)  Polydopamine-coated cerium oxide core–shell nanoparticles for efficient and non-damaging chemical–mechanical polishing.  DALTON TRANSACTIONS,      [PMID:39903199] [10.1039/D4DT03546A]

14. Wendong Yang, Pei Liu, Linfeng Wang, Jintao Meng, Hua Jiang, Shuangyan Gui, Jinhua Guo, Jun Wang, Jun Zhou, Jiangjiang Duan.  (2024)  Revisiting the attenuation mechanism of alkaline all-iron ion redox flow batteries.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.150491]

15. Xiaofeng Yang, Zhanglin Lin, Ya Xiang, Binrui Chen, Zisha Lao.  (2025)  A Robust and Easy Protein Purification Method Using SpyDock-Modified Resin.  Bio-protocol,  15  (8): (e5270).  [PMID:40291415] [10.21769/BioProtoc.5270]

16. Yiyao Zhang, Guangyun Zhang, Fen Yang, Zhikang Zou.  (2025)  Development of Mobile-Phase Buffers and Evaluation of Analytical Performance for HbA1c Assays.  BIOMEDICAL CHROMATOGRAPHY,  39  (10): (e70136).  [PMID:40884333] [10.1002/bmc.70136]

17. Pan An, Yijie Fan, Yujia Lv, Hao Xiu, Wenwen Li, Sen Yang, Zeyu Song, Yu Zhou, Huiting Ma, Mengshen Zhang, Panxing Ren, Pengfei Li, Jiaxing Wu, Yongpeng Cui, Dan Luo, Yajun Wang.  (2026)  Accelerating electron injection in NiFeOx/Co:BiVO4 via dopamine-mediated interfacial electric field for self-powered water oxidation.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2026.126953]