BIS-TRIS propane - ≥98% , CAS No.64431-96-5

CAS: 64431-96-5 Cat. No.: B299299 Molecular Weight: 282.33 Beilstein Registry Number: 1786109 EC Number: 264-899-3

GRADE & PURITY ≥98%

Synonyms

Bis-Tris propane | MFCD00004689 | Q4917173 | SY018877 | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | BIS-TRIS propane, anhydrous, free-flowing, Redi-Dri(TM), >=99.0% | UNII-N5YD0CS4DO | 1,3-Bis(tris[hydro

Storage

Room temperature,Argon charged

Shipped In

Normal

Overview

useful pH range 6.3 - 9.5 pKa (25 °C) (1) 6.8, (2) 9.0 BIS-TRIS Propane is Good′s buffer. It acts as ligand and forms series of dinuclear hydroxo complexes with Lanthanides(III) in the pH range 7-9. It is useful for diagnostic assay manufacturing industry.

application：

BIS-TRIS Propane may be used in the following studies:

As buffer to investigate the influence of anions with varying nucleophilic properties on the autoxidation of oxymyoglobin (MbO2).

Purification of glucose-binding protein from membranes of Sulfolobus solfataricus.

As buffer during GeO2 mineralisation. 

Specifications

Synonyms

Bis-Tris propane | MFCD00004689 | Q4917173 | SY018877 | 2-[3-(2-HYDROXY-1, 1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1, 3-DIOL | BIS-TRIS propane, anhydrous, free-flowing, Redi-Dri(TM), >=99.0% | UNII-N5YD0CS4DO | 1, 3-Bis(tris[hydro

Specifications & Purity

≥98%

Storage

Room temperature, Argon charged

Shipped In

Normal

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504756970
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756970
• Canonical Smiles: C(CNC(CO)(CO)CO)CNC(CO)(CO)CO
• IUPAC Name: 2-[3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propylamino]-2-(hydroxymethyl)propane-1,3-diol
• InChIKey: HHKZCCWKTZRCCL-UHFFFAOYSA-N
• INCHI: 1S/C11H26N2O6/c14-4-10(5-15,6-16)12-2-1-3-13-11(7-17,8-18)9-19/h12-19H,1-9H2
• Isomeric SMILES: C(CNC(CO)(CO)CO)CNC(CO)(CO)CO
• WGK Germany: 3
• Molecular Weight: 282.33
• Beilstein: 1786109
• Reaxy-Rn: 1786109
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1786109&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Amines
        • Level5 Alkanolamines
          • Level6 1,2-aminoalcohols

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Alkanolamines
• Direct Parent: 1,2-aminoalcohols
• Alternative Parents: Dialkylamines Primary alcohols Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: 1,2-aminoalcohol - Secondary amine - Secondary aliphatic amine - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Alcohol - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.
• External Descriptors: hexol

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water
• Sensitivity: Moisture sensitive
• Melt Point(°C): 164-165°C
• Molecular Weight: 282.330 g/mol
• XLogP3: -4.600
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 12
• Exact Mass: 282.179 Da
• Monoisotopic Mass: 282.179 Da
• Topological Polar Surface Area: 145.000 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 183.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Jie Gu, Shuyun Zheng, Xiaolong Lu, Hao Zhang, Kai Ren, Ziqiang Liu, Chao Liu, Chunrui Wu.  (2024)  A new strategy for solving hydrophobic membrane wetting: membrane structure design for membrane pore drying by spontaneous dehydration.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2024.123664]

2. Jiandong Shen, Bijiang Zhong, Wenshui Xia, Yanshun Xu.  (2024)  Action of structural proteins in textural deterioration of grass carp (Ctenopharyngodon idellus) fillets during refrigerated storage.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  59  (4): (2659-2666).  [PMID:] [10.1111/ijfs.17010]

3. Seokjoon Kim, Seungjin Lee, Seokhwan Kim, Jiye Shin, Byung Seok Cha, Eun Sung Lee, Ki Soo Park.  (2024)  Colorimetric detection of arsenite using Tris-mediated gold nanoparticle aggregation and chitosan lateral flow strip-based signal enhancement.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2024.135469]

4. Bao-Di Ma, Jia-Yi Li, Jian-He Xu, Tao Yu, Xu-Dong Kong.  (2025)  ADP-ribose is a competitive inhibitor of methanol dehydrogenases from Bacillus methanolicus.  JOURNAL OF BIOLOGICAL CHEMISTRY,      [PMID:40818608] [10.1016/j.jbc.2025.110599]

5. Yu Han, Yuelin Luo, Bao-Di Ma, Jie Li, Jian-He Xu, Xu-Dong Kong.  (2024)  Structural Insights of a cis-Epoxysuccinate Hydrolase Facilitate the Development of Robust Biocatalysts for the Production of l-(+)-Tartrate.  BIOCHEMISTRY,      [PMID:38803051] [10.1021/acs.biochem.4c00141]