Vilobelimab (anti-complément C5) - Primary antibody, specific to C5, Human IgG4SP, INHIBITOR of Complement C5 inhibitor, INHIBITOR of Complement C5 inhibitor

CAS: 2250440-41-4 Cat. No.: Ab182712
DISPONIBLE À COMMANDE
GRADE & PURITY Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ≥95%(SDS-PAGE&SEC-HPLC) See COA
Application
Animal Model, ELISA, Flow Cytometry, Functional Assay
Host species
Human
Reactive species
African green monkey, Human
Isotype
Human IgG4SP
Conjugation
Unconjugated
★
Size
USA
Allemagne (EU)*
Price
Qty
100μg
Ab182712-100μg
En stock ≥10
—
113,90$US
1mg
Ab182712-1mg
2 En stock
—
571,90$US
5mg
Ab182712-5mg
1 En stock
—
1 479,90$US
10mg
Ab182712-10mg
Fabrication sur commande aux États-Unis · 2–4 semaines ·
—
2 367,90$US
Enter a quantity for the sizes you want to add.
🧪
Why this grade

Sans transporteur, Recombinant, ExactAb™, Faible Endotoxine, Sans Azide, Validé, ≥95%(SDS-PAGE&SEC-HPLC), Voir COA Animal Free,Azide Free,Carrier Free,ExactAb™,Low Endotoxin,Recombinant,Validated for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Conserver à -80°C, éviter les congélations et décongélations répétées Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Vue d’ensemble

Le vilobélimab (anti-complément C5) est un anticorps monoclonal anti-C5a dirigé contre l'allergène C5a, un produit pro-inflammatoire de la division du complément qui joue un rôle central dans la médiation du dysfonctionnement des organes. Le vilobélimab (anti-complément C5) agit comme un inhibiteur de C5a, inhibant l'activation des neutrophiles, la chimiotaxie et réduisant la signalisation inflammatoire. Il peut être utilisé dans des études liées à la septicémie, au COVID-19, etc.
Pureté
≥95% (SDS-PAGE&SEC)
Niveau d'endotoxine
≤1.0EU/mg
Fonction de la protéine
L'activation du C5 par une C5 convertase initie l'assemblage spontané des composants tardifs du complément, C5-C9, dans le complexe d'attaque membranaire. C5b possède un site de liaison transitoire pour C6. Le complexe C5b-C6 est la base sur laquelle le complexe lytique est assemblé.
Dérivée de la dégradation protéolytique du complément C5, l'anaphylatoxine C5 est un médiateur du processus inflammatoire local. Elle induit la contraction des muscles lisses, augmente la perméabilité vasculaire et provoque la libération d'histamine par les mastocytes et les leucocytes basophiles. La C5a stimule également la locomotion des leucocytes polymorphonucléaires (chimiokinèse) et dirige leur migration vers les sites d'inflammation (chimiotaxie).

Specifications

Product Name
Vilobelimab (anti-complément C5) - Primary antibody, specific to C5, Human IgG4SP, INHIBITOR of Complement C5 inhibitor
Synonymes
Anticorps C3 et PZP-like alpha-2-macroglobulin domain-containing protein 4 | Anticorps C5 | Anaphylatoxine C5a | Anticorps C5a | Anticorps C5b | Anticorps CO5_HUMAN | Anticorps de la chaîne alpha'' du complément C5 | Anticorps du complément C5 | Composant
Spécifications et pureté
Sans transporteur, Recombinant, ExactAb™, Faible Endotoxine, Sans Azide, Validé, ≥95%(SDS-PAGE&SEC-HPLC), Voir COA
Espèce hôte
Human
Spécificité
C5
Conjugation
Unconjugated
Grade
Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Type d'action
INHIBITOR
Mécanisme d'action
INHIBITOR of Complement C5 inhibitor
Isotype
Human IgG4SP
Type de chaîne lumineuse
kappa
SDS-PAGE
27.0 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 192.2 kDa, under non-reducing conditions.
Méthode de purification
Protein A purified
Concentration
See COA
CAS
2250440-41-4
Stockage et expédition
Conditions de stockage de stockage
Conserver à -80°C, éviter les congélations et décongélations répétées
Expédié en
Dry ice packs + Cold packs
Stabilité et stockage
Conserver à -80℃ pendant 24 mois. Dès réception, il est recommandé de faire une aliquote. Éviter les cycles de congélation/décongélation.
Images

Vilobelimab (anti-Complement C5) (Ab182712) - ELISA
Immobilized Human Complement C5 Protein at 2.0 μg/mL can bind Vilobelimab (anti-Complement C5) (Ab182712) with the EC₅₀ of 69.06 ng/mL.

Vilobelimab (anti-Complement C5) (Ab182712) - SEC
The purity of Vilobelimab (anti-Complement C5) (Ab182712) is more than 95% verified by HPLC.

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Cibles associées (humaines)
C5 Tclin Complement C5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Mécanismes d'action
Certificats (CoA, COO, BSE/TSE et tableau d'analyse)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateArticle
ZJ24F0708110Certificate of AnalysisMay 19, 2026 Ab182712
ZJ24F0708111Certificate of AnalysisMay 19, 2026 Ab182712
ZJ24F0708112Certificate of AnalysisMay 19, 2026 Ab182712
FAQ et articles
Calculateurs de solution
Avis

Avis des clients

Need help choosing the grade?

Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.

View Animal Free grade guide → View Carrier Free grade guide → View Recombinant grade guide → View Validated grade guide → View ExactAb™ grade guide → View Low Endotoxin grade guide → View Azide Free grade guide →

Produits apparentés

Mouse Anti-Human IgM Antibody - Secondary antibody, for ELISA various applications, from Human, generated in Mouse, IgG1
Mouse Anti-Human IgG H&L (HRP) - Secondary antibody, for ELISA various applications, from Human, generated in Mouse, IgG1
Goat Anti-Human IgG H&L (HRP) - Secondary antibody, for WB,ELISA,IHC various applications, from Human, generated in Goat, IgG
Mouse Anti-Human IgG Antibody - Secondary antibody, for ELISA,CLIA various applications, from Human, generated in Rat, IgG1
Human IgG - Isotype Control Antibody, for WB,CLIA,LF,EIA,PRTIA various applications, generated in Human, >95%, IgG
Goat Anti-Human IgG Antibody - Secondary antibody, ≥ 95%
Mouse Anti-Human IgA H&L Antibody - Secondary antibody, Mouse IgG1
Goat Anti-Human IgG (HRP) - Secondary antibody
Goat Anti-Human IgG (Biotin) - Secondary antibody
Goat Anti-Human IgG (Cy5) - Secondary antibody
Goat Anti-Human IgG (APC) - Secondary antibody
Goat Anti-Human IgG (PE) - Secondary antibody
Goat Anti-Human IgG (TRITC) - Secondary antibody
Goat Anti-Human IgG (FITC) - Secondary antibody
Tesidolumab (anti-Complement C5) - Primary antibody, specific to C5, >95%, Human IgG1, BINDING AGENT of Complement C5 binding agent
Ravulizumab (anti-Complement C5) - Primary antibody, specific to C5, >95%, Human IgG2, INHIBITOR of Complement C5 inhibitor
Mouse Anti-Human IgE epsilon chain Antibody - Secondary antibody
Eculizumab (anti-Complement C5) - Primary antibody, specific to C5, >95%, Human IgG2+Human IgG4, INHIBITOR of Complement C5 inhibitor
Goat Anti-Human IgG Fc Antibody - Secondary antibody, Goat IgG
Crovalimab (anti-Complement C5) - Primary antibody, specific to C5, Human IgG1, INHIBITOR of Complement C5 inhibitor
Pozelimab (anti-Complement C5) - Primary antibody, specific to C5, Human IgG4SP, INHIBITOR of Complement C5 inhibitor
Human IgG2-Kappa - Isotype Control Antibody, Human IgG2
Human IgG3-kappa - Isotype Control Antibody, Human IgG3
Human IgG1-kappa, anti-Spike RBD - Isotype Control Antibody, specific to Spike RBD, Human IgG1
Human IgG4-kappa - Isotype Control Antibody, IgG4
Goat Anti-Human IgG (AF647) - Secondary antibody, IgG
Goat Anti-Human IgG (AF405) - Secondary antibody, IgG
Human IgG (FITC) - Isotype Control Antibody, IgG
Human IgG (APC) - Isotype Control Antibody, IgG
Human IgG (PE) - Isotype Control Antibody, IgG
Human IgG1(P331S/E430G)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(P331S/E430G)
Human IgG1(D265A/N297A)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(D265A/N297A)
Human IgG1(K409R/E356D/M358L)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(K409R/E356D/M358L)
Human IgG1(P329G/E356D/M358L)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(P329G/E356D/M358L)
Human IgG1(F405L)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(F405L)
Human IgG1(N297Q)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(N297Q)
Human IgG (Biotin) - Isotype Control Antibody, IgG
Human IgG1(N297S)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(N297S)
Human IgG1(E233A/L235A)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(E233A/L235A)
Human IgG1(K214R/N297A)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(K214R/N297A)
Human IgG1(K214R/L234A/L235A)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(K214R/L234A/L235A)
Human IgG1(N297A/E356D/M358L)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(N297A/E356D/M358L)
Human IgG1(L234F/L235E)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(L234F/L235E)
Human IgG1(D265A)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(D265A)
Human IgG1(K214R/L234F/L235E/P331S)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(K214R/L234F/L235E/P331S)
Human IgG1(K214R/E356D/M358L)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(K214R/E356D/M358L)
Human IgG1(L234A/L235A/G237A)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(L234A/L235A/G237A)
Human IgG1(L234A/L235A/F405L)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(L234A/L235A/F405L)
Human IgG1(D270N)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(D270N)
Human IgG4(S228P)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG4(S228P)
Human IgG1(N297A)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG1(N297A)
Human IgG4(S228P/L235E/P329G)-kappa, anti-HEL - Isotype Control Antibody, specific to HEL, Human IgG4(S228P/L235E/P329G)
Human IgG1-lambda1, anti-Spike RBD - Isotype Control Antibody, specific to Spike RBD, Human IgG1
Human IgG1-lambda2, anti-Spike RBD - Isotype Control Antibody, specific to Spike RBD, Human IgG1
Goat Anti-Human IgG (AF555) - Secondary antibody, IgG
Lendalizumab (anti-Complement C5) - Primary antibody, specific to C5, Human IgG2SA
Human IgG1-kappa (AF405), anti-Spike RBD - Isotype Control Antibody, specific to Spike RBD
Human IgG1-kappa (AF647), anti-Spike RBD - Isotype Control Antibody, specific to Spike RBD
Human IgG1-kappa (APC), anti-Spike RBD - Isotype Control Antibody, specific to Spike RBD
Human IgG1-kappa (Biotin), anti-Spike RBD - Isotype Control Antibody, specific to Spike RBD
Human IgG1-kappa (AF700), anti-Spike RBD - Isotype Control Antibody, specific to Spike RBD
Human IgG1-kappa (FITC), anti-Spike RBD - Isotype Control Antibody, specific to Spike RBD
Human IgG1-kappa (AF555), anti-Spike RBD - Isotype Control Antibody, specific to Spike RBD
Centrose patent anti-dysadherin (anti-Dysadherin) - Primary antibody, specific to FXYD5
Human IgG (AF647) - Isotype Control Antibody
Human IgG (AF488) - Isotype Control Antibody
Human IgG (AF700) - Isotype Control Antibody
Human IgG (AF405) - Isotype Control Antibody
Goat Anti-Human IgG (AF488) - Secondary antibody
Goat Anti-Human IgG Fc (Cy5) - Secondary antibody
Goat Anti-Human IgG Fc (AF555) - Secondary antibody, specific to Human IgG Fc
Goat Anti-Human IgG Fc (TRITC) - Secondary antibody
Goat Anti-Human IgG Fc (AF700) - Secondary antibody, specific to Human IgG Fc
Goat Anti-Human IgG Fc (AF405) - Secondary antibody
Goat Anti-Human IgG Fc (Biotin) - Secondary antibody, specific to Human IgG Fc
Goat Anti-Human IgG Fc (AF647) - Secondary antibody
Goat Anti-Human IgG Fc (FITC) - Secondary antibody, specific to Human IgG Fc
Human IgG (AF555) - Isotype Control Antibody

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