Chloramphenicol - Moligand™, ≥98%(HPLC), Ready Made Solution, 100mg/mL in ethanol: isopropanol (95:5) , CAS No.56-75-7

CAS: 56-75-7 Cat. No.: C476223 Formule: C₁₁H₁₂Cl₂N₂O₅ Poids moléculaire: 323.13 Beilstein Registry Number: 2225532 Numéro CE: 200-287-4

GRADE & PURITY Moligand™, ≥98%(HPLC), Ready Made Solution, 100mg/mL in ethanol: isopropanol (95:5)

Synonyms

Chloramex | Laevomycetinum | Chloramfilin | Chloramsaar | Chlornitromycin | Ertilen | Chloramficin | Chloro-25 vetag | Chloronitrin | Ciplamycetin | Econochlor | Micoclorina | Stanomycetin | Aquamycetin | Austracil | chloramphenicol | Chloroamphenicol | C

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Application：

Chloramphenicol is a synthetic antibiotic, which is isolated from Ziziphus veneeri. It usually takes 10-20 μ The concentration of g/mL is used for bacterial selection in molecular biology applications and as a selector for transformed cells containing Chloramphenicol resistance genes.

Preparation instructions:

This product is a ready made solution of 100 mg/mL in ethanol:isopropanol (95:5). It is shipped in dry ice and stored at -20°C.

Explanation：

Store in a closed container in a dry and ventilated place. Open containers must be carefully resealed and kept upright to prevent leakage. Storage level (TRGS 510): Flammable liquid ")

Specifications

Synonymes

Chloramex | Laevomycetinum | Chloramfilin | Chloramsaar | Chlornitromycin | Ertilen | Chloramficin | Chloro-25 vetag | Chloronitrin | Ciplamycetin | Econochlor | Micoclorina | Stanomycetin | Aquamycetin | Austracil | chloramphenicol | Chloroamphenicol | C

Spécifications et pureté

Moligand™, ≥98%(HPLC), Ready Made Solution, 100mg/mL in ethanol: isopropanol (95:5)

Mécanismes biochimiques et physiologiques

1、Action mechanism: Chloramphenicol blocks the Peptidyl transferase step by combining with 50S Ribosome subunit and preventing aminoacyl tRNA from attaching to Ribosome, thus inhibiting the synthesis of bacterial protein. It also inhibits the synthesis of

Conditions de stockage de stockage

Protected from light,Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Pureté

≥98%(HPLC)

Propriétés du produit

ALogP

1.1

Noms et identifiants

Pubchem Sid

528772763

Sourires canoniques

C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

IUPAC Name

2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide

InChIKey

WIIZWVCIJKGZOK-RKDXNWHRSA-N

INCHI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

Isomères SMILES

C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

WGK Allemagne

3

RTECS

AB6825000

Poids moléculaire

323.13

Beilstein

2225532

Reaxy-Rn

2063328

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2063328&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Nitrobenzenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Nitrobenzenes
• Intermediate Tree Nodes: Not available
• Direct Parent: Nitrobenzenes
• Alternative Parents: Nitroaromatic compounds Secondary alcohols Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Carboximidic acids Primary alcohols Organopnictogen compounds Organonitrogen compounds Organochlorides Organic zwitterions Organic oxides Hydrocarbon derivatives Aromatic alcohols Alkyl chlorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Nitrobenzene - Nitroaromatic compound - C-nitro compound - Secondary alcohol - Organic nitro compound - Carboximidic acid - Carboximidic acid derivative - Organic oxoazanium - Allyl-type 1,3-dipolar organic compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Aromatic alcohol - Organopnictogen compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Organochloride - Alkyl halide - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Organic zwitterion - Alcohol - Alkyl chloride - Organic oxide - Hydrocarbon derivative - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as nitrobenzenes. These are compounds containing a nitrobenzene moiety, which consists of a benzene ring with a carbon bearing a nitro group.
• External Descriptors: Aromatic compounds

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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TAS2R41 Tchem Taste receptor type 2 member 41 (0 Activities)

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TAS2R8 Tchem Taste receptor type 2 member 8 (0 Activities)

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PDE5A Tclin Phosphodiesterase 5A (5113 Activities)

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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

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F2 Tclin Thrombin (11687 Activities)

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CA2 Tclin Carbonic anhydrase II (17698 Activities)

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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HMGCR Tclin HMG-CoA reductase (2475 Activities)

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NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

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INSR Tclin Insulin receptor (5558 Activities)

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PGR Tclin Progesterone receptor (8562 Activities)

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ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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VDR Tclin Vitamin D receptor (26531 Activities)

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ACE Tclin Angiotensin-converting enzyme (1423 Activities)

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DRD2 Tclin Dopamine D2 receptor (23596 Activities)

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GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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DRD4 Tchem Dopamine D4 receptor (7907 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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HRH2 Tclin Histamine H2 receptor (5428 Activities)

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ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)

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HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)

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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

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HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)

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AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)

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ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

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AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

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CALCR Tclin Calcitonin receptor (2215 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

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HRH1 Tclin Histamine H1 receptor (7573 Activities)

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ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

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AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)

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OPRD1 Tclin Delta opioid receptor (15096 Activities)

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OPRK1 Tclin Kappa opioid receptor (16155 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

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SLC18A2 Tclin Synaptic vesicular amine transporter (118 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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alr Alanine racemase (2 Activities)

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Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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folP Dihydropteroate synthase (129 Activities)

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Alternaria solani (773 Activities)

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Schaalia meyeri (78 Activities)

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Enterococcus durans (113 Activities)

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Vibrio anguillarum (183 Activities)

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Trichophyton benhamiae (1686 Activities)

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Nannizzia gypsea (2039 Activities)

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Streptococcus (3973 Activities)

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Streptococcus sobrinus (228 Activities)

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Streptococcus pneumoniae (31063 Activities)

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Enterococcus (1748 Activities)

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Arthroderma uncinatum (22 Activities)

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Paraphyton cookei (39 Activities)

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Eggerthella lenta (139 Activities)

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Nannizzia nana (27 Activities)

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Campylobacter jejuni (634 Activities)

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Helicobacter pylori (3113 Activities)

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Pseudomonas (460 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Burkholderia cepacia (649 Activities)

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Pseudomonas fluorescens (1630 Activities)

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Pseudomonas putida (467 Activities)

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Sinorhizobium meliloti (74 Activities)

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Fusarium solani (1274 Activities)

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Enterobacter cloacae (7976 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Proteus (150 Activities)

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Proteus vulgaris (5823 Activities)

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Salmonella typhimurium (15756 Activities)

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Shigella boydii (323 Activities)

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Shigella flexneri (1836 Activities)

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Vibrio cholerae (1211 Activities)

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Vibrio parahaemolyticus (473 Activities)

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Vibrio vulnificus (80 Activities)

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Pasteurella multocida (1166 Activities)

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Bacteroides fragilis (1445 Activities)

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Bacteroides thetaiotaomicron (562 Activities)

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Parabacteroides distasonis (282 Activities)

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Fusobacterium mortiferum (179 Activities)

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Fusobacterium varium (184 Activities)

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Mécanismes d'action

Propriétés chimiques et physiques

• Sensibilité: Light sensitive
• Rotation spécifique [α]: 20 ° (C=5, EtOH)
• Point d'éclair (°F): 57.2°F closed cup
• Point d'éclair (°C): 14.0°C closed cup
• Point de fusion (°C): 149-153°C
• Poids moléculaire: 323.130 g/mol
• XLogP3: 1.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 322.012 Da
• Monoisotopic Mass: 322.012 Da
• Topological Polar Surface Area: 115.000 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 342.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1