Cimetidine - Moligand™, 10mM in DMSO , Histamine H2 receptor antagonist, CAS No.51481-61-9, Histamine H2 receptor antagonist

CAS: 51481-61-9 Cat. No.: C408701 Molecular Weight: 252.34 EC Number: 257-232-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

SKF-92334 | 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.
In vitro

In vivo

Cell Data

cell lines：MV4-11

Concentrations：

Incubation Time：

Powder Purity:≥96%

Specifications

Synonyms

SKF-92334 | 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST, INHIBITOR

Mechanism of action

Histamine H2 receptor antagonist

Names and Identifiers

• Isomeric SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N
• WGK Germany: 3
• RTECS: MF0035500
• Molecular Weight: 252.34
• Reaxy-Rn: 807826
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=807826&ln=

Associated Targets(Human)

HRH2 Tclin Histamine H2 receptor (4 Activities)

Discover Target: HRH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC29A4 Tchem Equilibrative nucleoside transporter 4 (1 Activities)

Discover Target: SLC29A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC47A2 Tchem Multidrug and toxin extrusion protein 2 (1 Activities)

Discover Target: SLC47A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC47A1 Tchem Multidrug and toxin extrusion protein 1 (1 Activities)

Discover Target: SLC47A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 56 mg/mL (201.97 mM); Water: ˂1 mg/mL Ethanol: ˂1 mg/mL
• Melt Point(°C): 141°C

References

1. Lu Zhao, Jie Liu, Yunfeng Bai, Feng Feng, Xiaoming Yang.  (2021)  Exploration of carbon dots derived from epimedium towards detecting dopamine and hydrogen peroxide.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2021.127179]

2. Renjie Xu, Hongdan Zhu, Lingmin Hu, Beimeng Yu, Xiaohua Zhan, Yichu Yuan, Ping Zhou.  (2020)  Characterization of the intestinal absorption of morroniside from Cornus officinalis Sieb. et Zucc via a Caco-2 cell monolayer model.  PLoS One,  15  (5): (e0227844).  [PMID:32470043] [10.1371/journal.pone.0227844]

3. Lisha Jin, Sisi Zhou, Shujie Zhu, Shaowei Lei, Weijuan Du, Huidi Jiang, Su Zeng, Hui Zhou.  (2019)  Dehydrocorydaline induced antidepressant-like effect in a chronic unpredictable mild stress mouse model via inhibiting uptake-2 monoamine transporters.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:31604070] [10.1016/j.ejphar.2019.172725]

4. Qingquan Zeng, Mengru Bai, Cui Li, Shuanghui Lu, Zhiyuan Ma, Yunchun Zhao, Hui Zhou, Huidi Jiang, Dongli Sun, Caihong Zheng.  (2019)  Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine.  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,      [PMID:31160284] [10.1128/AAC.00199-19]

5. Yufeng Chen, Fan Xue, Guobin Xia, Zhenlei Zhao, Chun Chen, Yunhong Li, Ying Zhang.  (2019)  Transepithelial transport mechanisms of 7,8-dihydroxyflavone, a small molecular TrkB receptor agonist, in human intestinal Caco-2 cells.  Food & Function,  10  (8): (5215-5227).  [PMID:31384856] [10.1039/C9FO01007F]

6. Renjie Xu, Yichu Yuan, Jia Qi, Jia Zhou, Xiaowen Guo, Jian Zhang, Ruanjuan Zhan.  (2018)  Elucidation of the Intestinal Absorption Mechanism of Loganin in the Human Intestinal Caco-2 Cell Model.  Evidence-based Complementary and Alternative Medicine,      [PMID:30671130] [10.1155/2018/8340563]

7. Xu Renjie, Peng Ying, Wang Mengyue, Li Xiaobo.  (2018)  Intestinal Absorption of Isoalantolactone and Alantolactone, Two Sesquiterpene Lactones from Radix Inulae, Using Caco-2 Cells.  EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS,  44  (2): (295-303).  [PMID:30209793] [10.1007/s13318-018-0510-x]

8. Li Wang, Yan Sun, Qi Liu.  (2015)  Determination of Pharmaceuticals and Personal Care Product Components in Wastewater Using Capillary Electrophoresis Coupled with Solid Phase Extraction.  ANALYTICAL LETTERS,      [PMID:] [10.1080/00032719.2014.966377]

9. Guodong Shan, Xiuqin Fan, Qingcheng Wang, Li Zhang, Lijun Ge, Weibo Lu, Jing Xue, Kang Chen, Zejun Wang, Qing Shen.  (2025)  Development of a Captiva EMR-lipid clean-up and LC-MS/MS methodology for detecting H2 receptor antagonists in functional foods and food-medicine homology materials.  Applied Food Research,      [PMID:] [10.1016/j.afres.2025.100772]