CPS2 - ≥99% , CAS No.2756741-90-7

CAS: 2756741-90-7 Cat. No.: C646566 Formule: C₃₈H₄₂N₁₂O₁₀S₂ Poids moléculaire: 890.94

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

Vue d’ensemble

CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader ( IC 50 = 24 nM). CPS2 can be used for the research of acute myeloid leukemia

In Vitro

CPS2 (5~333 nM; 12 hours; Ramos cells) stands out as the most potent degrader. CPS2 (0.5~2 μM; HSCs) inhibits the proliferation of HSCs without inducing cytotoxicity. CPS2 (1~10000 nM; 48 hours; NB4 cells) induces potent CDK2 degradation. CPS2 (250 nM; 0~6 hours; Ramos and NB4 cells) rapidly induces the degradation of CDK2. CPS2 (10~500 nM; 6 hours; Ramos cells) induces only CDK2 degradation and does not directly perturb the other CDK proteins under subnanomolar concentration conditions. CPS2 (250 nM; 6 hours; NB4 cells) stands out as the most downregulated protein in cells treated for 6 hours with CPS2, confirming the selectivity of CPS2 for CDK2. CPS2 (0~250 nM; NB4 cells) makes the levels of CDK2 obviously decreased. CPS2 (2 μM; 3 days; HL60 cells) obviously promotes ATRA-induced CD11b upregulation. The antileukemic effects of CPS2 are mediated by CDK2 degradation. CPS2 also induces granulocytic differentiation of HSCs, as assessed by cell morphological analysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Ramos cells Concentration: 5~333 nM Incubation Time: 12 hours Result: Stood out as the most potent degrader.

Form:Solid

IC50& Target:CDK2 24 nM (IC 50 )

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader ( IC 50 = 24 nM). CPS2 can be used for the research of acute myeloid leukemia.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥99%

Noms et identifiants

• Poids moléculaire: 890.94

Propriétés chimiques et physiques

• Solubilité: DMSO : 32.5 mg/mL (36.48 mM; Need ultrasonic)