≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Protected from light,Argon charged,Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of metalloproteinase ADAM8 with an IC 50 value of 182 nM. cyclo(RLsKDK) (TFA) has potential applications in inflammatory diseases and cancer.
Appearance:Solid
In Vitro:cyclo(RLsKDK) (TFA) promotes ADAM8 activation and CD23 shedding with IC 50 values of 120 nM and 182 nM, respectively. cyclo(RLsKDK) (TFA) (200 nM; 0-120 h) increases activity of pro-ADAM8. cyclo(RLsKDK) (TFA) (200 nM and 500 nM; 12 h) promotes t
In Vivo:cyclo(RLsKDK) (TFA) (10 µg/g; i.p.; once weekly for 4 weeks) significantly reduces tumour load in mice which implant Panc1_ctrl or Panc1_A8 cells. cyclo(RLsKDK) (TFA) improves the survival rate of pancreatic ductal adenocarcinoma (PDAC) mice, reduces solu
Biological Activity:cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of metalloproteinase ADAM8 with an IC 50 value of 182 nM. cyclo(RLsKDK) (TFA) has potential applications in inflammatory diseases and cancer.
Specifications
Specifications & Purity
≥98%
Storage
Protected from light, Argon charged, Desiccated, Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
Molecular Weight
841.88
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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