D-Sérine - Moligand™, ≥98.5% , Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D, CAS No.312-84-5, Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D

CAS: 312-84-5 Cat. No.: S105977 Formule: C₃H₇NO₃ Poids moléculaire: 105.09 Beilstein Registry Number: 1721403 Numéro CE: 206-229-4

GRADE & PURITY Moligand™, ≥98.5%

Synonyms

D-Ser | (R)-Serine | D-(+)-Serine;d-serine;D-2-Amino-3-hydroxypropionic acid; (R)-2-Amino-3-hydroxypropionic acid | N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide | A20674 | C00740 | s6224 | NCGC00094363-10 | NCGC00094363-07 | NCGC00261773-01 |

Storage

Room temperature

Shipped In

Normal

Vue d’ensemble

La D-sérine a été utilisée comme substrat de l'activité de la D-aminoacide oxydase (DAO) dans les cellules d'astrocytome humain 1321N1. Elle a également été utilisée en administration intracérébroventriculaire chez le rat pour l'induction d'un effet antinociceptif.

La D-sérine a été utilisée pour prévenir la désensibilisation glycine-dépendante du récepteur N-méthyl D-aspartate (NMDAR) et pour étudier ses effets sur les NMDAR afin de corriger les anomalies comportementales chez les rats après ligature partielle du nerf sciatique (PSNL)

description du produit：

La D-sérine est un acide aminé inhabituel exprimé dans le cerveau des mammifères. La D-sérine est un acide aminé dextro présent dans les neurones, les astrocytes et la microglie. Elle est synthétisée à partir de la L-sérine par l'enzyme sérine racémase. La racémase catalyse également la dégradation de la D-sérine en ammoniaque et en pyruvate. Elle est oxydée en hydroxypyruvate par la D-aminoacide oxydase.

application：

La D-sérine est impliquée dans la biosynthèse des purines, des pyrimidines et d'autres acides aminés. La D-sérine est également un agoniste du site glycine du récepteur du glutamate de type NMDA. Elle agit également comme intermédiaire du Lacosamide.

Specifications

Synonymes

D-Ser | (R)-Serine | D-(+)-Serine;d-serine;D-2-Amino-3-hydroxypropionic acid; (R)-2-Amino-3-hydroxypropionic acid | N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide | A20674 | C00740 | s6224 | NCGC00094363-10 | NCGC00094363-07 | NCGC00261773-01 |

Spécifications et pureté

Moligand™, ≥98.5%

Mécanismes biochimiques et physiologiques

Agoniste au niveau du site de liaison de la glycine NMDA et du récepteur post-synaptique inhibiteur de la glycine.

Conditions de stockage de stockage

Room temperature

Expédié en

Normal

Grade

Moligand™

Type d'action

AGONIST

Mécanisme d'action

Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D

Note

Dans la mesure du possible, les solutions doivent être préparées et utilisées le même jour. Toutefois, si vous devez préparer des solutions de base à l'avance, nous vous recommandons de les conserver sous forme d'aliquotes dans des flacons hermétiques à -20°C. Ces aliquotes sont généralement utilisables pendant un mois. En général, ces solutions peuvent être utilisées pendant un mois. Avant utilisation, et avant d'ouvrir le flacon, nous vous recommandons de laisser votre produit s'équilibrer à température ambiante pendant au moins 1 heure. Se référer à la FDS pour plus d'informations Vous avez besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥98.5%

Noms et identifiants

Pubchem Sid

488184641

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488184641

Sourires canoniques

C(C(C(=O)O)N)O

IUPAC Name

(2R)-2-amino-3-hydroxypropanoic acid

InChIKey

MTCFGRXMJLQNBG-UWTATZPHSA-N

INCHI

1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

Isomères SMILES

C([C@H](C(=O)O)N)O

WGK Allemagne

3

Poids moléculaire

105.09

Beilstein

1721403

Reaxy-Rn

1721402

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1721402&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Serine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Serine and derivatives
• Alternative Parents: D-alpha-amino acids Beta hydroxy acids and derivatives Amino acids Monocarboxylic acids and derivatives Carboxylic acids Primary alcohols Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Serine or derivatives - Alpha-amino acid - D-alpha-amino acid - Beta-hydroxy acid - Hydroxy acid - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Alcohol - Primary amine - Primary alcohol - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Primary aliphatic amine - Organic oxide - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as serine and derivatives. These are compounds containing serine or a derivative thereof resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Other amino acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 (0 Activities)

Discover Target: GRIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2A Tclin Glutamate receptor ionotropic, NMDA 2A (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2B Tclin Glutamate receptor ionotropic, NMDA 2B (0 Activities)

Discover Target: GRIN2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2D Tclin Glutamate receptor ionotropic, NMDA 2D (0 Activities)

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GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

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SLC1A4 Tbio Neutral amino acid transporter A (18 Activities)

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Cortex (4 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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BLM Tchem Bloom syndrome protein (4248 Activities)

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RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

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SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)

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GRIN1 Tclin Ionotropic glutamate receptor NMDA 1/2D (23 Activities)

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SLC1A5 Tchem Neutral amino acid transporter B(0) (65 Activities)

Discover Target: SLC1A5

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Hdac6 Histone deacetylase 6 (222 Activities)

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Staphylococcus aureus (210822 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Slc16a10 Monocarboxylate transporter 10 (73 Activities)

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Grin1 Glutamate NMDA receptor; Grin1/Grin2c (1127 Activities)

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Slc1a5 Amino acid transporter (271 Activities)

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Slc7a10 Asc-type amino acid transporter 1 (14 Activities)

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in water (346 mg/ml at 20°C), and mineral acids. Insoluble in alcohol, ether, and benzene.
• Rotation spécifique [α]: -15 ° (C=10, HCl(1+5))
• Point de fusion (°C): 220°C
• Poids moléculaire: 105.090 g/mol
• XLogP3: -3.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 105.043 Da
• Monoisotopic Mass: 105.043 Da
• Topological Polar Surface Area: 83.600 Ų
• Heavy Atom Count: 7
• Formal Charge: 0
• Complexity: 72.600
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1