Dexmedetomidine - Moligand™, ≥98% , Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor, CAS No.113775-47-6, Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor

CAS: 113775-47-6 Cat. No.: D129818 Molecular Weight: 200.28 EC Number: 601-281-8
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
(S)-5-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole | 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole | DEXMEDETOMIDINE | MPV 1440 | Dexmedetomidina [INN-Spanish] | Medetomidine, (s)- | 113775-47-6 (free base) | 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imid
Storage
Store at 2-8°C,Protected from light
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
50mg
D129818-50mg
3
$96.90
100mg
D129818-100mg
2
$154.90
250mg
D129818-250mg
1
$308.90
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C,Protected from light Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 22 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

Specifications

Synonyms
(S)-5-(1-(2, 3-Dimethylphenyl)ethyl)-1H-imidazole | 4-[(1S)-1-(2, 3-dimethylphenyl)ethyl]-1H-imidazole | DEXMEDETOMIDINE | MPV 1440 | Dexmedetomidina [INN-Spanish] | Medetomidine, (s)- | 113775-47-6 (free base) | 5-[(1S)-1-(2, 3-dimethylphenyl)ethyl]-1H-imid
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
A sedative, analgestic, α2-Adrenergic agonist and (+)-isomer of medetomidine.
Storage
Store at 2-8°C, Protected from light
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor
Purity
≥98%
Names and Identifiers
Canonical SmilesCC1=C(C(=CC=C1)C(C)C2=CN=CN2)C
IUPAC Name5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
InChIKeyCUHVIMMYOGQXCV-NSHDSACASA-N
INCHI1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1
Isomeric SMILES CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C
Molecular Weight 200.28
Reaxy-Rn 5379243
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5379243&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassXylenes
Intermediate Tree Nodes Not available
Direct Parento-Xylenes
Alternative Parents Imidazoles  Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents O-xylene - Heteroaromatic compound - Imidazole - Azole - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as o-xylenes. These are aromatic compounds that contain a o-xylene moiety, which is a monocyclic benzene carrying exactly two methyl groups at the 1- and 2-positions.
External Descriptors medetomidine
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C9 Tchem Cytochrome P450 2C9 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA2B Tclin Alpha-2B adrenergic receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA2C Tclin Alpha-2C adrenergic receptor (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA2A Tclin Alpha-2A adrenergic receptor (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA1D Tclin Alpha-1D adrenergic receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adra1b Adrenergic receptor alpha-1 (5652 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adra2c Adrenergic receptor alpha-2 (3313 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

20 results found

Lot NumberCertificate TypeDateItem
F2608342Certificate of AnalysisJun 12, 2026 D129818
F2608343Certificate of AnalysisJun 12, 2026 D129818
F2608344Certificate of AnalysisJun 12, 2026 D129818
L2314115Certificate of AnalysisSep 17, 2025 D129818
L2314114Certificate of AnalysisSep 17, 2025 D129818
H2525241Certificate of AnalysisAug 26, 2025 D129818
H2525242Certificate of AnalysisAug 26, 2025 D129818
H2525243Certificate of AnalysisAug 26, 2025 D129818
C2505288Certificate of AnalysisMar 10, 2025 D129818
C2505290Certificate of AnalysisMar 10, 2025 D129818
L2314117Certificate of AnalysisNov 29, 2023 D129818
L2314116Certificate of AnalysisNov 29, 2023 D129818
L2216874Certificate of AnalysisJan 06, 2023 D129818
H2325065Certificate of AnalysisDec 13, 2022 D129818
B2317695Certificate of AnalysisDec 13, 2022 D129818
B2317660Certificate of AnalysisDec 13, 2022 D129818
B2317637Certificate of AnalysisDec 13, 2022 D129818
K1628018Certificate of AnalysisJun 20, 2022 D129818
B2222164Certificate of AnalysisFeb 28, 2022 D129818
A2218067Certificate of AnalysisJan 25, 2022 D129818

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Chemical and Physical Properties
SolubilitySoluble in chloroform, and methanol.
SensitivityLight sensitive
Melt Point(°C)146-149°C
Molecular Weight200.280 g/mol
XLogP33.100
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass200.131 Da
Monoisotopic Mass200.131 Da
Topological Polar Surface Area28.700 Ų
Heavy Atom Count15
Formal Charge0
Complexity205.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Gao Yang, Kang Kai, Liu Yan-song, Li Na-na, Han Qiu-yuan, Liu Hai-tao, Kong Wei-lan, Zhang Xing, Huang Rui, Yang Zhen-yu, Qi Zhi-dong, Zheng Jun-bo, Li Ming, Wang Hong-liang, Li Jia-yu, Liu Rui-jin, Wang Si-cong, Zhang Wei-hua, Zhao Ming-yan, Yu Kai-jiang.  (2020)  Mechanisms of Renal-Splenic Axis Involvement in Acute Kidney Injury Mediated by the α7nAChR-NF-κB Signaling Pathway.  INFLAMMATION,  44  (2): (746-757).  [PMID:33141376] [10.1007/s10753-020-01374-y]
2. Wang Huikang, Cao Shiya, Pan Di, Faisal Ayub Kiani, Li Hao, Nan Sha, Lin Xuan, Mahmoud M. Abouelfetouh, Zulfiqar Ahmed, Ding Mingxing, Ding Yi.  (2025)  Elucidation of Dexmedetomidine-Induced Analgesic Tolerance Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and NR2B Expression via the Spinal SGK1/NF-κB Signalling Pathway.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  29  (6): (e70372).  [PMID:40099662] [10.1111/jcmm.70372]
3. Zengjun Xie, Zhihui He, Zhen Yuan, Miao Wang, Feifan Zhou.  (2024)  The Regulation of Cerebral Lymphatic Drainage in the Transverse Sinus Region of the Mouse Brain.  Journal of Biophotonics,      [PMID:39289863] [10.1002/jbio.202400250]
4. Xufeng Sun, Danlan Fang, Xiaoyu Zhang, Hongjing Zhu, Yingying Sun, Guantong Liu, Bin Sun, Jun Lu, Shoujun Zhu.  (2025)  Engineering Near-Infrared-II Nanoprobes Reveal Dexmedetomidine Potentiating Brain Waste Clearance in Healthy and Sleep-Restricted Mice.  ACS Nano,      [PMID:41004722] [10.1021/acsnano.5c10519]
5. Chenglong Li, Shuhao Xu, Xin Li, Huaiyu Su, Can Qian, Yingying Hou, Sanjun Shi.  (2025)  A Transformable Nanoplatform Precisely Positions Fibroblast-Like Synoviocytes via FAP-α for Improved Rheumatoid Arthritis Therapy.  Advanced Healthcare Materials,      [PMID:40931560] [10.1002/adhm.202503277]
6. Yimei Yang, Jing Xie, Junsu Wang, Hongyu Tu, Ping Lu, Kun Yu, Fei Lu, Guangqian Lan, Ruiqi Xie, Rong Yin, Enling Hu, Wentao Lin, Xianglin Lin.  (2025)  Polyphenol-functionalized silk fibroin incorporates self-assembled drug delivery platforms for oral ulcers treatment by robust wet adhesion and sustained drug release.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40945820] [10.1016/j.ijbiomac.2025.147592]
7. Zhuohui Luo, Zaibin Xu, Kongyan Wang, Huiyu Hu, Jiawen Huang.  (2025)  Citri Sarcodactylis Fructus Alleviates LPS‐Induced Acute Lung Injury by Inhibiting Inflammation and Inflammasome Activation.  Food Science & Nutrition,  13  (9): (e70881).  [PMID:40901654] [10.1002/fsn3.70881]
8. XiaoRong Meng, Dandan Meng, Chenhui Xiang, Lingling Pu, Xiaofei Yin, Jing Yang.  (2025)  Apelin-13 treats postmenopausal osteoporosis by reducing mitochondrial oxidative phosphorylation and modulating the OPG/RANK/RANKL/IGF-1 pathway.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:41043277] [10.1016/j.bbrc.2025.152738]
9. Yaqing Kang, Xiaoqing Han, Shijie Zhou, Xingbo Wang, Yanjing Wang, Panpan Song, Xiaochen Su, Mengmeng Qin, Dongyang Qian, Huan Meng, Jiao Yan, Fang Pu, Haiyuan Zhang.  (2025)  Engineered Apoptotic Extracellular Vesicles for Programmable Regulation of Neutrophil-Macrophage-ROS Pathogenic Axis to Reconstruct Rheumatoid Arthritis Microenvironment.  ADVANCED MATERIALS,      [PMID:41041946] [10.1002/adma.202508072]
10. Hui Ma, Jiancheng Zhao, Wenbo Dong, Gang Wei, Pan Zhou, Xingshun Cong, Kefeng Wu, Yingxiong Wang, Jing Liao, Qi Zhao.  (2025)  High-resolution pure shift NMR spectroscopy for fast structural analysis of complex drug compounds with overlapping multiplets.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2025.142492]
11. Shixin Lu, Zhaopeng Cai, Yuheng Lu, Youchen Tang, Jiapeng Song, Jiajun Huang, Ziying Cheng, Dingcai Wu, Peng Wang.  (2025)  A universal strategy for growing multifunctional hydrogel coatings on diverse polymers via Fenton reaction.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.163936]
12. Lan Tang, Xin Zhang, Ye Huang, Depeng Kong, Yiwen Yan, Zhimin Ou, Mulan Zhu, Yi Li, Jianwei Wang.  (2025)  Study on dexamethasone-fast dissolving oral film based on pullulan-vitamin E succinic acid.  Journal of Radiation Research and Applied Sciences,      [PMID:] [10.1016/j.jrras.2025.101653]
13. Liang Shan, Liu Shiwei, Long Zhihe, Li Xiaojiao, Han Qian, Wei Xianhao, Xing Lili, Xue Xinyu, Chen Meihua.  (2025)  A self-powered hydration-monitoring and drug-delivery skin patch for closed-loop treatment of atopic dermatitis.  Microsystems & Nanoengineering,  11  (1): (1-14).  [PMID:40825931] [10.1038/s41378-025-01000-7]
14. Renjie Cao, Tingting Zhao, Ying Wang, Shaofei Song, Yuan Li, Mengling Hou, Yanxin Zhang, Sengpeng Wong, Siqi Wang, Yuran Wang, Hong Peng, Min Huang, Yiming Jiang.  (2025)  Constitutive Androstane Receptor in Macrophages Regulates Toll-Like Receptor 4-Mediated Innate Immune Responses Against Endotoxemic Liver Injury.  Advanced Science,      [PMID:40820881] [10.1002/advs.202506725]
15. Yu Li, Pei Xie, Ruixin Gong, Junlong Chen, Yaxue Liu, Zongning Yin.  (2025)  Treating rheumatoid arthritis using fibroblast-activated protein-α-responsive micelles through a cascade control program.  Journal of Materials Chemistry B,      [PMID:41114432] [10.1039/D5TB01441G]
16. Qianqian Wang, Juan Du, Enling Ye, Zhongyan Bao, Minjie Zhao, Jing Wang, Fengqin Feng, Weihong Min, Hong Yang.  (2025)  Wheat peptides improved sarcopenia by enhancing muscle protein synthesis in mice and zebrafish.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.107717]
17. Sifang Zhao, Fengjiao Chen, Mengxin Ban, Jian Zhou, Kerong Wu, Tengbo Yu, Bowen Chen, Lingling Zhao, Ziyu Liu.  (2025)  Phenylboronic Acid-Modified and ROS-Responsive Polymeric Nanoparticles for Targeted Anticancer Drug Delivery.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.5c03593]
18. Pengchao Zhao, Zhishen Zhang, Dianhao Gong, Hongzhen Luo, Huiying Yu, Xin Li, Kun Lei, Chunshan Quan, Yun Xue, Lijun Guan.  (2025)  Multifunctional Prussian-Blue-Based Nanocomposite Hydrogel for Infected Wound Regeneration.  Gels,  11  (11): (895).  [PMID:41294580] [10.3390/gels11110895]
19. Min-Jie Shi, Jiang-Zheng Liu, Wei-Hua Yu, Rui Liu, Lu-Yao Li, Meng Cao, Yun-Ze Tian, Xiao-Di Zhang, Hao Wu, Jian-Zhong Li, Chun-Xu Hai, Wen-Li Li, Jia Li, De-Qin Kong.  (2025)  Repurposing the anesthetic dexmedetomidine: a novel antidote for sulfur mustard analog-induced acute lung injury via multi-mechanism modulation.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:41421231] [10.1016/j.intimp.2025.116069]
20. Gongshuai Song, Tian Zhao, Yingcong Yang, Yangcheng Ge, Wei Tang, Taijiao Xiang, Danli Wang, Tinglan Yuan, Ling Li, Yong Cheng, Mengna Zhang, Jinyan Gong.  (2026)  Promoting the formation of β-lactoglobulin amyloid fibrils induced by cold plasma treatment: self-assembly mechanism, emulsifying properties, and stability.  FOOD RESEARCH INTERNATIONAL,      [PMID:41763791] [10.1016/j.foodres.2026.118469]
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