DMOG - ≥98%(HPLC) , CAS No.89464-63-1

CAS: 89464-63-1 Cat. No.: D136754 Formule: C₆H₉NO₅ Poids moléculaire: 175.14 Numéro CE: 686-981-1

GRADE & PURITY ≥98%(HPLC)

Synonyms

AS-40798 | methyl N-(2-methoxy-2-oxoacetyl)glycinate | methyl n-[methoxy(oxo)acetyl]glycinate | Glycine, N-(methoxyoxoacetyl)-, methyl ester | methyl 2-((2-methoxy-2-oxoethyl)amino)-2-oxoacetate | methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate | 2-(m

Storage

Conserver à -20°C

Shipped In

Glacière + blocs de glace

Vue d’ensemble

Le Diméthyloxallyl Glycine (DMOG) est un inhibiteur compétitif de HIF-PH (HIF-1α prolyl hydroxylase), perméable aux cellules.

Specifications

Synonymes

AS-40798 | methyl N-(2-methoxy-2-oxoacetyl)glycinate | methyl n-[methoxy(oxo)acetyl]glycinate | Glycine, N-(methoxyoxoacetyl)-, methyl ester | methyl 2-((2-methoxy-2-oxoethyl)amino)-2-oxoacetate | methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate | 2-(m

Spécifications et pureté

≥98%(HPLC)

Mécanismes biochimiques et physiologiques

Le DMOG est un inhibiteur de la prolyl-4-hydroxylase perméable aux cellules, qui régule à la hausse le HIF (facteur inductible à l'hypoxie). Le niveau protéique de la sous-unité HIF-1α est régulé de manière post-transcriptionnelle par la prolyl et l'aspar

Conditions de stockage de stockage

Conserver à -20°C

Expédié en

Glacière + blocs de glace

Type d'action

INHIBITOR

Note

Dans la mesure du possible, les solutions doivent être préparées et utilisées le même jour. Toutefois, si vous devez préparer des solutions de base à l'avance, nous vous recommandons de les conserver sous forme d'aliquotes dans des flacons hermétiques à -20°C. Ces aliquotes sont généralement utilisables pendant un mois. En général, ces solutions peuvent être utilisées pendant un mois. Avant utilisation, et avant d'ouvrir le flacon, nous vous recommandons de laisser votre produit s'équilibrer à température ambiante pendant au moins 1 heure. Se référer à la FDS pour plus d'informations Vous avez besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥98%(HPLC)

Noms et identifiants

Pubchem Sid

488190296

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488190296

Sourires canoniques

COC(=O)CNC(=O)C(=O)OC

IUPAC Name

methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate

InChIKey

BNJOZDZCRHCODO-UHFFFAOYSA-N

INCHI

1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)

Isomères SMILES

COC(=O)CNC(=O)C(=O)OC

WGK Allemagne

3

Poids moléculaire

175.14

Reaxy-Rn

2096268

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2096268&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 N-acyl-alpha amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: N-acyl-alpha amino acids and derivatives
• Alternative Parents: Alpha amino acid esters Dicarboxylic acids and derivatives Methyl esters Secondary carboxylic acid amides Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Alpha-amino acid ester - N-acyl-alpha amino acid or derivatives - Dicarboxylic acid or derivatives - Methyl ester - Carboxamide group - Carboxylic acid ester - Secondary carboxylic acid amide - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in water at 30mg/ml.
• Point d'ébullition (°C): 182 °C/12 mmHg
• Point de fusion (°C): 51 °C
• Poids moléculaire: 175.140 g/mol
• XLogP3: -0.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 175.048 Da
• Monoisotopic Mass: 175.048 Da
• Topological Polar Surface Area: 81.700 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 200.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1