(E)-[6]-Dehydroparadol - ≥95% , CAS No.878006-06-5

CAS: 878006-06-5 Cat. No.: D649327 Formule: C₁₇H₂₄O₃ Poids moléculaire: 276.37 PubChem CID: 6438480

GRADE & PURITY ≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol , is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells

In Vitro

(E)-[6]-Dehydroparadol (M15) (5-80 µM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC 50 s of 43.02 and 41.59 µM, respectively. (E)-[6]-Dehydroparadol (10-40 µM; 24 h) induces apoptosis in HCT-116 and H-1299 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(E)-[6]-Dehydroparadol (compound 19) (5 µM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Nrf2

Specifications

Spécifications et pureté

≥95%

Mécanismes biochimiques et physiologiques

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol ( HY-14616 ), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ACTIVATOR

Pureté

≥95%

Noms et identifiants

• Isomères SMILES: CCCCCCCC(=O)/C=C/C1=CC(=C(C=C1)O)OC
• PubChem CID: 6438480
• Poids moléculaire: 276.37

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO : ≥ 140 mg/mL (506.57 mM)
• Poids moléculaire: 276.400 g/mol
• XLogP3: 4.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 276.173 Da
• Monoisotopic Mass: 276.173 Da
• Topological Polar Surface Area: 46.500 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 299.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 878006-06-5, the molecular formula is C17H24O3, and the molecular weight is 276.37 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.