EN219 - ≥98% , CAS No.380351-29-1

CAS: 380351-29-1 Cat. No.: E651926 Formule: C₁₇H₁₃Br₂ClN₂O Poids moléculaire: 456.56

QUALITÉ & PURETÉ ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Application

230

Vue d’ensemble

EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC 50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination

In Vitro

EN219 (1 μM; 90 min) interacts with RNF114 C8, TUBB1 C201, HSPD1 C442, and HIST1H3A C97 demonstrated by isotopic tandem orthogonal proteolysisABPP (isoTOP-ABPP) analysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:RNF114 470 nM (IC 50 )

Spécifications

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC 50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination.

Conditions de stockage de stockage

Store at 2-8°C,Protected from light,Desiccated

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥98%

Noms et identifiants

Sourires canoniques

ClCC(N1N=C(C2=CC=C(Br)C=C2)CC1C3=CC=C(Br)C=C3)=O

Poids moléculaire

456.56

Propriétés chimiques et physiques

• Solubilité: DMSO : 65 mg/mL (142.37 mM; Need ultrasonic)