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(-)-Epigallocatechin gallate - Moligand™, ≥98% , Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B, CAS No.989-51-5, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B

CAS: 989-51-5 Cat. No.: E107404 Formule: C22H18O11 Poids moléculaire: 458.37 Beilstein Registry Number: 17(5)8,506 Numéro CE: 619-381-5
268 Citations COA
(-)-Epigallocatechin gallate - Moligand™, ≥98% CAS No(989-51-5) E107404 by Aladdin Scientific
DISPONIBLE À COMMANDE
QUALITÉ & PURETÉ Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
EGCG | EPIGALLOCATECHIN GALLATE [INCI] | Epigallocic acid | NCGC00164319-04 | EGCG | NCGC00164319-01 | UNII-BQM438CTEL | (-)-Epigallocatechin gallate (85% (-)-epigallocatechin gallate, 10% (-)-epigallocatechin, 5% (-)- epicatechin gallate) | SPECTRUM21023
Storage
Store at 2-8°C,Protected from light,Argon charged
Shipped In
Wet ice
★
Taille
USA
Allemagne (EU)*
Prix
Qté
25mg
E107404-25mg
4 En stock
—
9,90$US
100mg
E107404-100mg
2 En stock
—
10,90$US
500mg
E107404-500mg
6 En stock
—
12,90$US
2.5g
E107404-2.5g
8 En stock
—
14,90$US
5g
E107404-5g
Sur commande · 8–12 semaines
19,90$US
25g
E107404-25g
Sur commande · 8–12 semaines
49,90$US
Enter a quantity for the sizes you want to add.
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SDS
Safety data
COA
Certificate
DS
Fiche technique
SP
Fiche de spécifications
Vue d’ensemble Spécifications Noms et identifiants Documentation Données avancées Taxonomic Classification Structure 3D Cibles associées (humaines) Cibles associées (non humaines) Mécanismes d'action Certificats (CoA, COO, BSE/TSE et tableau d'analyse) Propriétés chimiques et physiques FAQ et articles Citations of This Product Calculateurs de solution Avis
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Pourquoi cette qualité

Moligand™, ≥98% Moligand™ pour les flux de travail chromatographiques et analytiques sensibles nécessitant une interférence de ligne de base minimale.

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Stockage & expédition

Store at 2-8°C,Protected from light,Argon charged Expédition Wet ice. Consultez le COA spécifique au lot pour les spécifications exactes.

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Documents qualité

SDS, COA, fiche technique et fiche de spécifications disponibles au téléchargement. COA spécifique au lot accessible via la recherche par numéro de lot.

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Preuve documentaire

Cité dans 268 publications à comité de lecture couvrant la chromatographie, la synthèse organique et les réactions de couplage croisé.

Vue d’ensemble

(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS).
An inhibitor of Bcl-2 and NOS2

Spécifications

Synonymes
EGCG | EPIGALLOCATECHIN GALLATE [INCI] | Epigallocic acid | NCGC00164319-04 | EGCG | NCGC00164319-01 | UNII-BQM438CTEL | (-)-Epigallocatechin gallate (85% (-)-epigallocatechin gallate, 10% (-)-epigallocatechin, 5% (-)- epicatechin gallate) | SPECTRUM21023
Spécifications et pureté
Moligand™, ≥98%
Mécanismes biochimiques et physiologiques
β-secretase (BACE1) inhibitor (IC50= 1.6μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ,α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate de
Conditions de stockage de stockage
Store at 2-8°C,Protected from light,Argon charged
Expédié en
Wet ice
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Grade
Moligand™
Type d'action
AGONIST, INHIBITOR
Mécanisme d'action
Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B
Pureté
≥98%
Noms et identifiants
Pubchem Sid
504753949
Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/504753949
Sourires canoniques
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
IUPAC Name
[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
InChIKey
WMBWREPUVVBILR-WIYYLYMNSA-N
INCHI
1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1
Isomères SMILES
C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
WGK Allemagne
2
RTECS
KB5200000
Numéro ONU
3077
Groupe d'emballage
III
Poids moléculaire
458.37
Beilstein
17(5)8,506
Reaxy-Rn
375093
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=375093&ln=

Documentation

📋 Fiche de données de sécurité (FDS)

Document complet couvrant les dangers, la manipulation, le stockage et la conformité réglementaire.

<<<<<<< HEAD Télécharger la SDS → ======= Télécharger la SDS → >>>>>>> release248-p3

✅ Certificat d'analyse (COA)

Données qualité spécifiques au lot. Saisissez votre numéro de lot pour récupérer le COA exact.

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📊 Fiche technique

Résumé de référence rapide des spécifications et applications du produit.

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🔬 Fiche de spécifications

Attributs de qualité complets et critères d'acceptation pour cette qualité.

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Données avancées

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClasseFlavonoids
SubclassFlavans
Intermediate Tree Nodes Flavan-3-ols - Catechins
Direct ParentCatechin gallates
Alternative Parents Epigallocatechins  3'-hydroxyflavonoids  4'-hydroxyflavonoids  5-hydroxyflavonoids  7-hydroxyflavonoids  Galloyl esters  p-Hydroxybenzoic acid alkyl esters  m-Hydroxybenzoic acid esters  1-benzopyrans  Pyrogallols and derivatives  Benzoyl derivatives  Alkyl aryl ethers  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Carboxylic acid esters  Monocarboxylic acids and derivatives  Oxacyclic compounds  Polyols  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Catechin gallate - Epigallocatechin - 3'-hydroxyflavonoid - 4'-hydroxyflavonoid - 5-hydroxyflavonoid - 7-hydroxyflavonoid - Hydroxyflavonoid - Galloyl ester - Gallic acid or derivatives - P-hydroxybenzoic acid alkyl ester - M-hydroxybenzoic acid ester - P-hydroxybenzoic acid ester - Benzoate ester - Chromane - Benzopyran - 1-benzopyran - Pyrogallol derivative - Benzenetriol - Benzoic acid or derivatives - Benzoyl - Alkyl aryl ether - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Benzenoid - Monocyclic benzene moiety - Carboxylic acid ester - Carboxylic acid derivative - Polyol - Oxacycle - Ether - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as catechin gallates. These are organic compounds containing a gallate moiety glycosidically linked to a catechin.
External Descriptors Proanthocyanidins
Structure 3D
Modèle de structure chimique interactif





Cibles associées (humaines)
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Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EP300 Tchem Histone acetyltransferase p300 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DYRK1A Tchem Dual specificity tyrosine-phosphorylation-regulated kinase 1A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
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STAT1 Tchem Signal transducer and activator of transcription 1-alpha/beta (1 Activities)
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ABCB1 Tchem Multidrug resistance protein 1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KAT2B Tchem Histone acetyltransferase KAT2B (1 Activities)
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TERT Tchem Telomerase reverse transcriptase (2 Activities)
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TTR Tclin Transthyretin (2 Activities)
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PGAM1 Tchem Phosphoglycerate mutase 1 (2 Activities)
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BCL2 Tclin Apoptosis regulator Bcl-2 (2 Activities)
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BACE1 Tchem Beta-secretase 1 (1 Activities)
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APP Tclin Amyloid-beta A4 protein (1 Activities)
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PGD Tchem 6-phosphogluconate dehydrogenase, decarboxylating (1 Activities)
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TAS2R5 Tchem Taste receptor type 2 member 5 (0 Activities)
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Mécanismes d'action
Certificats (CoA, COO, BSE/TSE et tableau d'analyse)
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34 results found

Lot NumberCertificate TypeDateArticle
J2613455J2613455Certificate of AnalysisOct 16, 2026 E107404
J2613448J2613448Certificate of AnalysisOct 16, 2026 E107404
J2613410J2613410Certificate of AnalysisOct 16, 2026 E107404
J2613411J2613411Certificate of AnalysisOct 16, 2026 E107404
J2613440J2613440Certificate of AnalysisOct 16, 2026 E107404
J2613437J2613437Certificate of AnalysisOct 16, 2026 E107404
A2606081A2606081Certificate of AnalysisOct 31, 2025 E107404
J2528383J2528383Certificate of AnalysisOct 31, 2025 E107404
J2528384J2528384Certificate of AnalysisOct 31, 2025 E107404
J2528634J2528634Certificate of AnalysisOct 31, 2025 E107404
J2528637J2528637Certificate of AnalysisOct 31, 2025 E107404
B2602297B2602297Certificate of AnalysisOct 31, 2025 E107404
E2508089E2508089Certificate of AnalysisMay 16, 2025 E107404
E2508082E2508082Certificate of AnalysisMay 16, 2025 E107404
B2527402B2527402Certificate of AnalysisMar 05, 2025 E107404
B2527401B2527401Certificate of AnalysisMar 05, 2025 E107404
B2527400B2527400Certificate of AnalysisMar 05, 2025 E107404
J2421532J2421532Certificate of AnalysisOct 29, 2024 E107404
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J2421530J2421530Certificate of AnalysisOct 29, 2024 E107404
D2416253D2416253Certificate of AnalysisApr 25, 2024 E107404
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L2318272L2318272Certificate of AnalysisDec 25, 2023 E107404
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G2214193G2214193Certificate of AnalysisNov 27, 2023 E107404
J2308486J2308486Certificate of AnalysisNov 16, 2023 E107404
J2308485J2308485Certificate of AnalysisNov 16, 2023 E107404
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L2215539L2215539Certificate of AnalysisJan 03, 2023 E107404
L2215631L2215631Certificate of AnalysisJan 03, 2023 E107404
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G2214195G2214195Certificate of AnalysisDec 20, 2021 E107404
G2214194G2214194Certificate of AnalysisDec 20, 2021 E107404
L2116394L2116394Certificate of AnalysisDec 20, 2021 E107404
Propriétés chimiques et physiques
SolubilitéSolvent:water, Max Conc. mg/mL: 4.58, Max Conc. mM: 10; Solvent:DMSO, Max Conc. mg/mL: 45.84, Max Conc. mM: 100
SensibilitéLight Sensitive；Air sensitive
Rotation spécifique [α]-175.5 ° (C=1, EtOH)
Point de fusion (°C)212°C
Poids moléculaire458.400 g/mol
XLogP31.200
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass458.085 Da
Monoisotopic Mass458.085 Da
Topological Polar Surface Area197.000 Ų
Heavy Atom Count33
Formal Charge0
Complexity667.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
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Citations of This Product
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Controlled-release & nanoparticle carrier58
Organic synthesis — reaction medium87
Drug / compound screening58
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Nanoparticle / material biocompatibility9
Cell viability11
Cytotoxicity screening15
Immune cell assay5
Industrial & non-pharma application4
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Extraction & workup solvent53
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Apoptosis (7044) dual specificity tyrosine phosphorylation regulated kinase 1A Inhibitor (17) E1A binding protein p300 Inhibitor (10) Endogenous Metabolite (1000) lysine acetyltransferase 2B Inhibitor (7) Metabolic Enzyme/Protease (4878) Metabolite (8554) TAS2R5 Agonist (3)

Produits apparentés

(-)-Epigallocatechin gallate - Moligand™, analytical standard , CAS No.989-51-5
(-)-Epigallocatechin Gallate - Moligand™, 10mM in DMSO , Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B, CAS No.989-51-5
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