Epothilone B - ≥98%(HPLC) , Tubulin stabiliser, CAS No.152044-54-7, Tubulin stabiliser

Name: Epothilone B - ≥98%(HPLC) , Tubulin stabiliser, CAS No.152044-54-7, Tubulin stabiliser
SKU: E100865
Availability: InStock

CAS: 152044-54-7 Cat. No.: E100865 Formule: C₂₇H₄₁NO₆S Poids moléculaire: 507.68 Numéro CE: 604-822-6

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Epothilone B - ≥98%(HPLC) CAS No(152044-54-7) by Aladdin Scientific

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DISPONIBLE À COMMANDE

GRADE & PURITY ≥98%(HPLC)

Synonyms

Storage

A l'abri de la lumière,A conserver à -20°C

Shipped In

Glacière + blocs de glace

Specifications Propriétés du produit Noms et identifiants Documentation Advanced Data Taxonomic Classification Structure 3D Cibles associées (humaines) Cibles associées (non humaines) Mécanismes d'action Certificats (CoA, COO, BSE/TSE et tableau d'analyse) Propriétés chimiques et physiques Citations of This Product Références Calculateurs de solution Avis

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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

A l'abri de la lumière,A conserver à -20°C Ships Glacière + blocs de glace Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonymes

Spécifications et pureté

≥98%(HPLC)

Mécanismes biochimiques et physiologiques

L'épothilone B (EPO906, Patupilone) est un agent stabilisateur des microtubules de type Taxol dont la CE0,01 est de 1,8 μM. L'épothilone B, agent de stabilisation des microtubules, favorise la polymérisation de la tubuline et induit l'arrêt du cycle cellu

Conditions de stockage de stockage

A l'abri de la lumière,A conserver à -20°C

Expédié en

Glacière + blocs de glace

Type d'action

STABILISER

Mécanisme d'action

Tubulin stabiliser

Note

Dans la mesure du possible, les solutions doivent être préparées et utilisées le même jour. Toutefois, si vous devez préparer des solutions de base à l'avance, nous vous recommandons de les conserver sous forme d'aliquotes dans des flacons hermétiques à -20°C. Ces aliquotes sont généralement utilisables pendant un mois. En général, ces solutions peuvent être utilisées pendant un mois. Avant utilisation, et avant d'ouvrir le flacon, nous vous recommandons de laisser votre produit s'équilibrer à température ambiante pendant au moins 1 heure. Besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥98%(HPLC)

Propriétés du produit

ALogP	4.2

Noms et identifiants

Pubchem Sid	504758872
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504758872
Sourires canoniques	CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C
IUPAC Name	(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
InChIKey	QXRSDHAAWVKZLJ-PVYNADRNSA-N
INCHI	1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
Isomères SMILES	C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C
WGK Allemagne	3
Poids moléculaire	507.68
Reaxy-Rn	25967768
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25967768&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Classe Macrolides and analogues
    - Subclass Epothilones and analogues

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Classe	Macrolides and analogues
Subclass	Epothilones and analogues
Intermediate Tree Nodes	Not available
Direct Parent	Epothilones and analogues
Alternative Parents	2,4-disubstituted thiazoles Heteroaromatic compounds Secondary alcohols Lactones Cyclic ketones Carboxylic acid esters Oxacyclic compounds Monocarboxylic acids and derivatives Epoxides Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Epothilone - 2,4-disubstituted 1,3-thiazole - Azole - Heteroaromatic compound - Thiazole - Carboxylic acid ester - Ketone - Lactone - Secondary alcohol - Cyclic ketone - Carboxylic acid derivative - Dialkyl ether - Oxirane - Ether - Oxacycle - Monocarboxylic acid or derivatives - Azacycle - Organoheterocyclic compound - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Carbonyl group - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organopnictogen compound - Alcohol - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as epothilones and analogues. These are macrolides consisting of a 16-member lactone ring conjugated at the carbon 16 with a 1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl group. Some epothilone analogues containing a lactam ring instead of the lactone ring.
External Descriptors	Macrolides and lactone polyketides
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Structure 3D

Cibles associées (humaines)

TUBB4B Tclin Tubulin beta-2 chain (26 Activities)

Discover Target: TUBB4B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR1I2 Tchem Pregnane X receptor (6667 Activities)

Discover Target: NR1I2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

1A9 (618 Activities)

Lot Number	Certificate Type	Date	Article
E2203238	Certificate of Analysis	Feb 04, 2026	E100865
E2203241	Certificate of Analysis	Feb 04, 2026	E100865
E2203272	Certificate of Analysis	Feb 04, 2026	E100865
I1318068	Certificate of Analysis	Apr 09, 2025	E100865
I2516050	Certificate of Analysis	Feb 26, 2022	E100865

Sensibilité	Light sensitive.
Rotation spécifique [α]	-36° (C=0.2,MeOH)
Point de fusion (°C)	94 °C
Poids moléculaire	507.700 g/mol
XLogP3	4.200
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	2
Exact Mass	507.265 Da
Monoisotopic Mass	507.265 Da
Topological Polar Surface Area	137.000 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	815.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	7
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Epothilone B - ≥98%(HPLC) , Tubulin stabiliser, CAS No.152044-54-7, Tubulin stabiliser

Why this grade

Storage & shipping

Quality documents

Literature proof

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Avis des clients

📚 Citations by Application

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