Epothilone D - ≥98% , Tubulin stabiliser, CAS No.189453-10-9, Tubulin stabiliser

Name: Epothilone D - ≥98% , Tubulin stabiliser, CAS No.189453-10-9, Tubulin stabiliser
Brand: Aladdin Scientific
SKU: E189063
Availability: InStock

CAS: 189453-10-9 Cat. No.: E189063 Formule: C₂₇H₄₁NO₅S Poids moléculaire: 491.68

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Epothilone D - ≥98% CAS No(189453-10-9) by Aladdin Scientific

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DISPONIBLE À COMMANDE

QUALITÉ & PURETÉ ≥98%

Synonyms

(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methylthiazol-4-yl)vinyl]-1-oxacyclohexadec-13-ene-2,6-dione|EPOTHILONE D [MI]|Z-12,13-desoxyepothilone B|Epo D|(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxacyclohexadec-13-ene-2,6-dione|EPOTHILONE D [WHO-DD]|(4S-(4R*,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione|Epothilone D|epothilone-D|OXACYCLOHEXADEC-13-ENE-2,6-DIONE, 4,8-DIHYDROXY-5,5,7,9,13-PENTAMETHYL-16-((1E)-1-METHYL-2-(2-METHYL-4-THIAZOLYL)ETHENYL)-, (4S,7R,8S,9S,13Z,16S)-|(4S,7R,8S,9S,16S,Z)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)oxacyclohexadec-13-ene-2,6-dione|N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide|12,13-desoxyepothilone b, cis|(2S)-1-{[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile|Epothiolone D|KOS 862|(-)-Epothilone D|Biologically synthesized Epothilone D|12,13-Deoxyepothilone B|(-)-Desoxyepothilone B|Desoxyepothilone b|DEpoB cpd|Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (4S,7R,8S,9S,13Z,16S)-|Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)-, (4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-|(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione|Dalcetrapib pound JTT-705 pound(c)|Desoxyepothilone B; (3S,7S,14S,15S,16R)-3,15-Dihydroxy-2,2,10,14,16-pentamethyl-7-[1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-6-oxacyclohexadec-9-ene-1,5-dione|KOS862|KOS-862|Epothilon D|Oxacyclohexadec-13-ene-2,6-dione, 4,6-dihydroxy-5,5,7,9,13-pentamethyl-16-((1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)-, (4S,7R,8S,9S,13Z,16S)-|Epothilone B, desoxy|12,13-Desoxyepothilone B|12,13-Desoxy-Epothilone B|(4S,7R,8S,9s,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-oxacyclohexadec-13-ene-2,6-dione|EPD

Storage

Conserver à -20°C

Shipped In

Glacière + blocs de glace

Fiche de spécifications

Spécifications Propriétés du produit Noms et identifiants Données avancées Taxonomic Classification Structure 3D Cibles associées (humaines) Cibles associées (non humaines) Mécanismes d'action Certificats (CoA, COO, BSE/TSE et tableau d'analyse) Propriétés chimiques et physiques Calculateurs de solution Avis Foire aux questions

Spécifications

Synonymes

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

Agent stabilisateur des microtubules. Analogue de l'épothilone A et B. Améliore la densité des microtubules et l'intégrité axonale. Effets antinéoplasiques et neuroprotecteurs in vivo. Perméable à la barrière hémato-encéphalique.

Conditions de stockage de stockage

Conserver à -20°C

Expédié en

Glacière + blocs de glace

Type d'action

STABILISER

Mécanisme d'action

Tubulin stabiliser

Note

Dans la mesure du possible, les solutions doivent être préparées et utilisées le même jour. Toutefois, si vous devez préparer des solutions de base à l'avance, nous vous recommandons de les conserver sous forme d'aliquotes dans des flacons hermétiques à -20°C. Ces aliquotes sont généralement utilisables pendant un mois. En général, ces solutions peuvent être utilisées pendant un mois. Avant utilisation, et avant d'ouvrir le flacon, nous vous recommandons de laisser votre produit s'équilibrer à température ambiante pendant au moins 1 heure. Besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥98%

Propriétés du produit

ALogP

Noms et identifiants

Pubchem Sid

504758870

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504758870

Sourires canoniques

CC1CCCC(=CCC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC2=CSC(=N2)C)C)C

IUPAC Name

(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione

InChIKey

XOZIUKBZLSUILX-GIQCAXHBSA-N

INCHI

1S/C27H41NO5S/c1-16-9-8-10-17(2)25(31)19(4)26(32)27(6,7)23(29)14-24(30)33-22(12-11-16)18(3)13-21-15-34-20(5)28-21/h11,13,15,17,19,22-23,25,29,31H,8-10,12,14H2,1-7H3/b16-11-,18-13+/t17-,19+,22-,23-,25-/m0/s1

Isomères SMILES

C[C@H]1CCC/C(=C\C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C2=CSC(=N2)C)/C)/C

Poids moléculaire

491.68

Reaxy-Rn

25203628

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25203628&ln=

Données avancées

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Classe Macrolides and analogues
    - Subclass Epothilones and analogues

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Classe	Macrolides and analogues
Subclass	Epothilones and analogues
Intermediate Tree Nodes	Not available
Direct Parent	Epothilones and analogues
Alternative Parents	2,4-disubstituted thiazoles Heteroaromatic compounds Secondary alcohols Lactones Cyclic ketones Carboxylic acid esters Oxacyclic compounds Monocarboxylic acids and derivatives Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Epothilone - 2,4-disubstituted 1,3-thiazole - Azole - Heteroaromatic compound - Thiazole - Carboxylic acid ester - Ketone - Lactone - Secondary alcohol - Cyclic ketone - Carboxylic acid derivative - Oxacycle - Monocarboxylic acid or derivatives - Azacycle - Organoheterocyclic compound - Alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Carbonyl group - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as epothilones and analogues. These are macrolides consisting of a 16-member lactone ring conjugated at the carbon 16 with a 1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl group. Some epothilone analogues containing a lactam ring instead of the lactone ring.
External Descriptors	Macrolides and lactone polyketides
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Structure 3D

Cibles associées (humaines)

ACHN (49357 Activities)

Lot Number	Certificate Type	Date	Article
K2328310	Certificate of Analysis	Sep 02, 2026	E189063
K2328311	Certificate of Analysis	Sep 02, 2026	E189063
K2328312	Certificate of Analysis	Sep 02, 2026	E189063
K2328313	Certificate of Analysis	Sep 02, 2026	E189063
K2328314	Certificate of Analysis	Sep 02, 2026	E189063
K2328315	Certificate of Analysis	Sep 02, 2026	E189063
K2328316	Certificate of Analysis	Sep 02, 2026	E189063
K2328317	Certificate of Analysis	Sep 02, 2026	E189063
J2523118	Certificate of Analysis	Nov 13, 2023	E189063
L2522133	Certificate of Analysis	Nov 13, 2023	E189063

Poids moléculaire	491.700 g/mol
XLogP3	5.000
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	491.271 Da
Monoisotopic Mass	491.271 Da
Topological Polar Surface Area	125.000 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	777.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	2
Covalently-Bonded Unit Count	1

Epothilone D - ≥98% , Tubulin stabiliser, CAS No.189453-10-9, Tubulin stabiliser

Spécifications

Données avancées

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