Factor XIII, CAS No.9013-56-3

CAS: 9013-56-3 Cat. No.: np330962

GRADE & PURITY BioReagent, Native, ≥94%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Accession #

P00488,P05160

Bioactivity

See COA

Vue d’ensemble

Human Factor XIII is a tetramer composed of two pairs of chains held together by noncovalent bonds. After activation of the zymogen via Thrombin to its active enzyme form, Factor XIIIa is responsible for catalyzing the formation of covalent bridges between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is very insoluble and resistant to lysis.

Buffer composition =50 mM Tris-HCl/0.1 M NaCl/1 mM EDTA/10u/mL aprotinin/20% glycerol/pH 7.5

Extinction Coefficient (1%)=13.8

Molecular Weight = 320,000 daltons

The human factor XIII is ≥94% as judged by SDS-PAGE. One plasma equivalent unit (PEU) is equal to ~108 Loewy units. The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.

Specifications

Product Name

Factor XIII, CAS No.9013-56-3

Synonymes

Native Human Factor XIII protein | Human Factor XIII Native Protein | Coagulation Factor XIII, Human Plasma | Human Factor XIII | Fibrin Stabilizing Factor | F13A1 | F13B | F13A | FXIIIB

Grade

BioReagent, Native

Spécifications et pureté

BioReagent, Native, ≥94%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Mécanismes biochimiques et physiologiques

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fib

Bioactivité

See COA

Accession #

P00488,P05160

Poids moléculaire prévu

320 kDa

CAS

9013-56-3

Type de molécule

Protein

Stockage et expédition

Concentration

from Human plasma; Protein concentration: See COA

Conditions de stockage de stockage

Store at -80°C,Avoid repeated freezing and thawing

Expédié en

Dry ice packs + Cold packs

Stabilité et stockage

Store at -80℃ long term. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Définition de l'unité

One plasma equivalent unit (PEU) is equal to ~108 Loewy units.