Recombinant Human GLIPR1L1 Protein: Properties & Applications

Recombinant Human GLIPR1L1 protein is a member of the GLIPR1 (Glioma Pathogenesis-Related Protein 1) family, belonging to the CAP superfamily, and is produced recombinantly for use as a research tool in cancer biology, immune regulation, and cell signaling studies.

Product Name

Recombinant Human GLIPR1L1 Protein

SKU

rp367973

Protein Family

GLIPR1 family; CAP superfamily (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 proteins)

Species Origin

Human (Homo sapiens)

Application Areas

Cancer biology, cell signaling, immune response, functional assays

Format

Recombinant protein

What Is GLIPR1L1?

GLIPR1L1 (GLI Pathogenesis-Related 1 Like 1) is a member of the GLIPR1 protein family, which belongs to the broader CAP superfamily. CAP superfamily proteins are defined by a conserved CAP domain and include cysteine-rich secretory proteins (CRISPs), antigen 5 proteins, and pathogenesis-related proteins of group 1 (PR-1). These proteins are found across eukaryotes and are involved in diverse biological processes including immune defense, cell proliferation, and apoptosis regulation.

GLIPR1L1 shares structural homology with other GLIPR family members and is thought to play roles in cell signaling and potentially in modulating immune responses. Like other CAP superfamily members, GLIPR1L1 may interact with lipids or membrane components, contributing to its biological activity.

Biochemical Properties of Recombinant Human GLIPR1L1 Protein

Recombinant Human GLIPR1L1 protein (SKU: rp367973) is produced using recombinant expression technology to ensure consistency and reproducibility across experiments. Recombinant production allows researchers to obtain well-defined protein preparations suitable for functional studies, binding assays, and use as standards in immunoassays.

The recombinant protein retains the characteristic CAP domain structure associated with the GLIPR family, which is important for its biological activity. Researchers should consult the product datasheet for specific details regarding purity, molecular weight, host expression system, formulation, and storage conditions, as these parameters are critical for experimental design and reproducibility.

Biological Functions and Research Significance

Members of the GLIPR1 family have attracted attention in the context of cancer biology and immune regulation. GLIPR1 itself has been studied for its roles in apoptosis induction and tumor suppression, and related family members such as GLIPR1L1 are of interest for understanding similar or complementary pathways. The CAP superfamily as a whole is implicated in innate immunity, cell-cell communication, and pathogen defense mechanisms.

Research into GLIPR1L1 may provide insights into mechanisms of tumor biology, immune evasion, or therapeutic targeting. Recombinant protein tools are essential for in vitro studies, including receptor binding characterization, signaling pathway analysis, and the development of antibody-based detection reagents.

Applications in Life Science Research

Recombinant Human GLIPR1L1 protein is suitable for a range of research applications:

• Functional assays: Investigating the role of GLIPR1L1 in cell proliferation, apoptosis, or immune activation using in vitro cell-based models.
• Protein–protein interaction studies: Identifying binding partners that mediate GLIPR1L1's biological effects.
• Immunoassay development: Serving as a standard or positive control in ELISA and other immunodetection platforms.
• Structural studies: Supporting efforts to characterize the three-dimensional structure of GLIPR1L1 and its CAP domain.

For optimal results, researchers should follow the handling and storage recommendations provided in the product datasheet and perform appropriate validation experiments for their specific assay systems.

Ordering and Storage Information

Recombinant Human GLIPR1L1 protein is available from Aladdin Scientific under SKU rp367973. For complete specifications—including purity grade, host expression system, formulation buffer, recommended storage temperature, and shelf life—please refer to the official product datasheet available on the Aladdin Scientific website.

When placing an order, lab managers and procurement teams should verify the required quantity and confirm cold-chain shipping requirements with Aladdin Scientific customer service to ensure product integrity upon arrival.

Frequently asked questions

What is GLIPR1L1 and why is it important for research?

GLIPR1L1 is a member of the GLIPR1 protein family and the CAP superfamily, proteins involved in immune defense, cell signaling, and apoptosis regulation. It is of interest to researchers studying cancer biology and immune modulation because related family members have demonstrated roles in tumor suppression and innate immunity.

What expression system is used to produce Recombinant Human GLIPR1L1 protein (rp367973)?

Specific details about the host expression system for rp367973 are provided in the product datasheet. Please consult the Aladdin Scientific product page or contact customer service for the most up-to-date technical specifications.

How should Recombinant Human GLIPR1L1 protein be stored?

Storage conditions, including recommended temperature and buffer formulation, are specified in the product datasheet for rp367973. In general, recombinant proteins should be stored according to the manufacturer's instructions, typically at -20°C or -80°C, and repeated freeze-thaw cycles should be avoided to maintain activity.

What quality controls are performed on rp367973?

Aladdin Scientific performs quality control testing on recombinant proteins to verify purity and identity. For specific QC data such as SDS-PAGE purity assessment and endotoxin levels for rp367973, please refer to the certificate of analysis (CoA) available upon request or on the product page.

Can Recombinant Human GLIPR1L1 protein be used in cell-based functional assays?

Yes, recombinant human GLIPR1L1 protein is suitable for use in cell-based functional assays, including studies of cell proliferation, apoptosis, and immune activation. Researchers should validate the protein's activity in their specific assay system and consult the datasheet for recommended working concentrations.

References

1. Gibbs GM, Roelants K, O'Bryan MK. The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins—roles in reproduction, cancer, and immune defense. Endocrine Reviews. 2008;29(7):865-897. doi:10.1210/er.2008-0032
2. Murphy EV, Zhang Y, Zhu W, Biggs J. The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors. Gene. 1995;159(1):131-135. PMID:7607556

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.