Tumors

On August 19, 2026, Merck and Moderna announced positive topline results from a Phase III clinical trial in melanoma. The study evaluated a patient-specific messenger RNA (mRNA) neoantigen therapy in combination with pembrolizumab. The therapy was previously designated mRNA-4157/V940 during ...

Peptides have become an important class of molecules in modern medicinal chemistry and chemical biology. Compared with traditional small molecules, peptides often offer higher target selectivity and stronger molecular recognition capability, while still retaining good structural tunability. As a ...

Vascular endothelial growth factor receptor (VEGFR) inhibitors are a class of compounds that block signaling through VEGF receptor tyrosine kinases. VEGFR plays a central role in angiogenesis, the formation of new blood vessels, which is a critical process in tumor growth and progression.

The anticancer drug Lenalidomide was once one of the world's top-selling small molecule drugs and orphan drugs, with sales of up to 9.978 billion US dollars in 2022, and its development company Celgene made huge profits.

Antibody-coupled drug ADCs are a hot frontier in cancer therapy, providing a targeted therapy approach that combines the specificity of monoclonal antibodies with the potency of cytotoxic agents.