Forsythin - analytical standard, ≥97% , CAS No.487-41-2

CAS: 487-41-2 Cat. No.: F104482 Molecular Weight: 534.55 PubChem CID: 24721571

GRADE & PURITY Analytical standard, ≥97%

Synonyms

Phillyrin | Phillyroside | Phyllyrin | Phillygenin β-D-Glucopyranoside | 4-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H | 3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl β-D-Glucopyranoside

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Specifications

Synonyms

Phillyrin | Phillyroside | Phyllyrin | Phillygenin β-D-Glucopyranoside | 4-[(1S, 3aR, 4R, 6aR)-4-(3, 4-Dimethoxyphenyl)tetrahydro-1H | 3H-furo[3, 4-c]furan-1-yl]-2-methoxyphenyl β-D-Glucopyranoside

Specifications & Purity

analytical standard, ≥97%

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Analytical standard

Purity

≥97%

Names and Identifiers

• Isomeric SMILES: COC1=C(C=C(C=C1)[C@H]2[C@H]3CO[C@@H]([C@H]3CO2)C4=C(C=C(C=C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)OC)OC
• PubChem CID: 24721571
• Molecular Weight: 534.55

Chemical and Physical Properties

• Sensitivity: Moisture sensitive
• Molecular Weight: 534.600 g/mol
• XLogP3: 0.800
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 8
• Exact Mass: 534.21 Da
• Monoisotopic Mass: 534.21 Da
• Topological Polar Surface Area: 146.000 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 757.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Ying Ju, Chunling Yin, Yan Zhang, Xiangru Meng, Liuchuang Zhao, Leqian Hu.  (2022)  Rapid detection and quality evaluation of Shuang-Huang-Lian injection by ATR-IR and NIR spectroscopy combined with chemometrics.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36283204] [10.1016/j.saa.2022.122008]

2. Xin Guo, Pingping Cao, Xiongfeng Lian, Meng Hu, Jingyi Zhao, Wenjing Shen, Haili Wang, Hailong Yu, Yingzhu Chen.  (2021)  The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:34425100] [10.1016/j.ejphar.2021.174439]

3. Duan Qiong, Li Ruochen, Wang Mingxiao, Cui Zhenting, Zhu Xia, Chen Fanghong, Han Feng, Ma Jianxin.  (2024)  Exploring the anti-NSCLC mechanism of phillyrin targeting inhibition of the HSP90-AKT pathway.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,      [PMID:39356318] [10.1007/s00210-024-03481-1]

4. Chenggang Huang, Jiajia Teng, Wei Liu, Junzhe Wang, An Liu.  (2024)  Modulation of macrophages by a phillyrin-loaded thermosensitive hydrogel promotes skin wound healing in mice.  CYTOKINE,      [PMID:38417214] [10.1016/j.cyto.2024.156556]

5. Kaiping Xiang, Bing Wang, Lanying Wang, Yunfei Zhang, Hanzeng Li, Yanping Luo.  (2024)  Oxidative Stress, Oxidative Damage, and Cell Apoptosis: Toxicity Induced by Arecoline in Caenorhabditis elegans and Screening of Mitigating Agents.  Toxins,  16  (8): (352).  [PMID:39195762] [10.3390/toxins16080352]

6. Zhirui Du, Xueqiao Yan, Lin Cheng, Haiyu Shen, Guoguo Zhi, Baojie Li, Qian Yu.  (2025)  Luteolin attenuates experimental dry eye disease via dual modulation of macrophage JAK-STAT signaling and corneal epithelial MAPK pathways.  PHYTOMEDICINE,      [PMID:41005053] [10.1016/j.phymed.2025.157300]

7. Feng Li, Xinrong Fan, Bohao Wang, Jingyang Tong, Menglai Ling, Haibin Tong, Yumei Huang.  (2025)  Phillyrin counters β2 integrin-mediated neutrophil adhesion and chemotaxis to alleviate endotoxin-induced acute lung injury in neonatal rats.  BIOCHEMICAL PHARMACOLOGY,      [PMID:40210127] [10.1016/j.bcp.2025.116934]