Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Galanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and
Storage
Protected from light, Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
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Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as galanthamine-type amaryllidaceae alkaloids. These are amaryllidaceae alkaloids with a structure characterized a tetracyclic skeleton with two ortho aromatic protons in ring A.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Yijing Liao, Xi Mai, Xiaqing Wu, Xing Hu, Xiaoqiao Luo, Guowen Zhang. (2022) Exploring the Inhibition of Quercetin on Acetylcholinesterase by Multispectroscopic and In Silico Approaches and Evaluation of Its Neuroprotective Effects on PC12 Cells. MOLECULES, 27 (22):(7971). [PMID:36432070][10.3390/molecules27227971]
2.Yijing Liao, Xing Hu, Junhui Pan, Guowen Zhang. (2022) Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation. Foods, 11 (2):(168). [PMID:35053900][10.3390/foods11020168]
3.Pei-Pei WANG, Guo-Wei ZHAO, Wen XIA, En-Ji HAN, Lan XIANG. (2014) A new flavonol C-glycoside and a rare bioactive lignanamide from Piper wallichii Miq. Hand.-Mazz. Chinese Journal of Natural Medicines, [PMID:24856762][10.1016/S1875-5364(14)60047-9]
4.Ping Chen, Pei-Pei Wang, Ze-Zhao Jiao, Lan Xiang. (2014) Sesquiterpenoids from the Fruits of Alpinia oxyphylla and Their Anti-Acetylcholinesterase Activity. HELVETICA CHIMICA ACTA, 97 (3):(388-397). [PMID:][10.1002/hlca.201300234]
5.Chang Xu, Xiao Yu, Guiyang Wang, Shiqing You, Linlin Zhu, Ying Liu, Nuan Zhang, Zhengdong Wang, Bin Liu, Wei Zhang. (2024) Affinity ultrafiltration based metabolomic profiling directed discovery novel butyrylcholinesterase inhibitors from Uncaria sessilifructus. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39084425][10.1016/j.ijbiomac.2024.134179]
6.Chen Zhan, Jiahui Zhang, Junxing Hao, Zhihong Liu, Chengguo Hu. (2024) Scalable drop-casting construction of light-addressable photoelectrochemical biosensor on laser-induced graphene electrode arrays for high-throughput drug screening. BIOSENSORS & BIOELECTRONICS, [PMID:38878700][10.1016/j.bios.2024.116497]
7.Yuexiang CHANG, Hao TIAN, Jia-Huan QU, Jiaming YUAN, Rongkai GU, TingTing ZHANG, Jincai WANG, Zhengjin JIANG. (2025) Establishment of an at-line nanofractionation-based screening platform for rapid identification of influenza PAN/PAN I38T inhibitors from Artemisiae Argyi. Journal of Pharmaceutical Analysis, [PMID:41732320][10.1016/j.jpha.2025.101402]
8.Zhixu Chen, Rongkai Gu, Mingming Zhao, Kefeng Linghu, Huanwei Fan, Tingting Zhang, Jincai Wang, Zhengjin Jiang. (2025) Rapid screening and identification of influenza virus polymerase inhibitors from Rubus idaeus L. by at-line nanofractionation. Journal of Chromatography Open, [PMID:][10.1016/j.jcoa.2025.100278]
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