GW4869 - ≥97% , CAS No.6823-69-4
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SKU
G340097
a cell permeable selective inhibitor of N-SMase (neutral sphingomyelinase) which functions as an inhibitor, via a non-competitve manner
GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). GW4869 functions as an inhibitor, via a non-competitve manner. N-SMases are important in the metabolism of sphingomyelin producing ceramide and phosphocholine, which are important in cell signaling and regulation. Studies indicate that GW4869 can inhibit the activation of N-SMase by TNF-α in MC7 cells. As a result of this inhibition cell death and growth suppression are inhibited. Although GW4869 does not effect polymorphonuclear neutrophil (PMN) motility, it is useful with formylmethionylleucylphenylanaline (FMLP), since it inhibits PMN aggregation towards the chemotaxin.
Plus d’information
| CAS | 6823-69-4 |
|---|---|
| Synonymes | GW4869 also known as N-SMase Inhibitor | GW-4869 | GW 4869 | Sphingomyelinase | Inhibitor GW4869 | 4',4''-Di-2-imidazolin-2-yl-p-benzenediacrylanilide dihydrochloride |
| Spécifications et pureté | ≥97% |
| Conditions de stockage de stockage | Store at 2-8°C,Desiccated |
| Expédié en | Wet ice |
| Product Description | GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). GW4869 functions as an inhibitor, via a non-competitve manner. N-SMases are important in the metabolism of sphingomyelin producing ceramide and phosphocholine, which are important in cell signaling and regulation. Studies indicate that GW4869 can inhibit the activation of N-SMase by TNF-α in MC7 cells. As a result of this inhibition cell death and growth suppression are inhibited. Although GW4869 does not effect polymorphonuclear neutrophil (PMN) motility, it is useful with formylmethionylleucylphenylanaline (FMLP), since it inhibits PMN aggregation towards the chemotaxin. |
| Pubchem Sid | 488199033 |
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488199033 |
| Solubilité | Soluble in DMSO (~0.2 mg/ml). |
| Sensibilité | Moisture sensitive |
| PubChem CID | 16078967 |
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