HSD1590 - 10mM in DMSO , CAS No.2379279-96-4

CAS: 2379279-96-4 Cat. No.: H655706 Formule: C₂₀H₁₈BN₃O₃ Poids moléculaire: 359.19 PubChem CID: 139030519

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2 , respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s<2 nM). HSD1590 displays low cytotoxicity

In Vitro

HSD1590 (0.5-1 µM; 24 hours) exhibits an impressive attenuation in migration. HSD1590 (0.5-10 µM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MDA-MB-23 cells Concentration: 0.5-10 µM Incubation Time: 12-24 hours Result: Exhibited approximately 80% viability at 12 hours and yielded an overall viability of 63% at 24 h.

IC50& Target:ROCK1 1.22 nM (IC 50 ) ROCK2 0.51 nM (IC 50 )

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2 , respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s<2 nM). HSD1590 displays low cytotoxicity.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

• Isomères SMILES: B(C1=C(C(=CC=C1)C2=NC3=C(C4=C2CCC4)C5=C(C=C3)NN=C5)OC)(O)O
• PubChem CID: 139030519
• Poids moléculaire: 359.19

Cibles associées (humaines)

ROCK2 Tclin Rho-associated protein kinase 2 (0 Activities)

Discover Target: ROCK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ROCK1 Tclin Rho-associated protein kinase 1 (0 Activities)

Discover Target: ROCK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2379279-96-4, the molecular formula is C20H18BN3O3, and the molecular weight is 359.19 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.