Ibrolipim - ≥95% , CAS No.133208-93-2

CAS: 133208-93-2 Cat. No.: L339156 Formule: C₁₉H₂₀BrN₂O₄P Poids moléculaire: 451.25 Numéro CE: 634-329-1

GRADE & PURITY ≥95%

Synonyms

DMAA (Antiparkinson Agent) | Ibrolipim [USAN] | J-006332 | Lipoprotein Lipase Activator | N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide | Q5984863 | 2-Methyl-1,4-naphthochinon | HY-117549 | NO-1886 | AKOS005067076 | Diethyl 4-((4-bromo-2

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Lipoprotein Lipase Activator is a cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARα or PPARγ agonistic activities. Lipoprotein Lipase Activator lowers serum lipid levels and plasma triglycerides with concomitant elevation in high-density lipoprotein cholesterol (HDL-C) in animal models. Lipoprotein Lipase Activator also induces fatty acid oxidation related enzymes, lowers free fatty acids (FFA), and minimizes fat accumulation. Also reported to suppress the plasma levels of TNF-a and COX-2 and displays anti-tumor properties.

Specifications

Synonymes

DMAA (Antiparkinson Agent) | Ibrolipim [USAN] | J-006332 | Lipoprotein Lipase Activator | N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide | Q5984863 | 2-Methyl-1,4-naphthochinon | HY-117549 | NO-1886 | AKOS005067076 | Diethyl 4-((4-bromo-2

Spécifications et pureté

≥95%

Mécanismes biochimiques et physiologiques

Lipoprotein lipase activator. Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Long-term administration of NO-1886 protects against the development of experimental athero

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ACTIVATOR

Pureté

≥95%

Propriétés du produit

pKa

pKa: 11.51 (Predicted)

Noms et identifiants

Pubchem Sid

528764933

Sourires canoniques

CCOP(=O)(CC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)Br)C#N)OCC

IUPAC Name

N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide

InChIKey

KPRTURMJVWXURQ-UHFFFAOYSA-N

INCHI

1S/C19H20BrN2O4P/c1-3-25-27(24,26-4-2)13-14-5-7-15(8-6-14)19(23)22-18-10-9-17(20)11-16(18)12-21/h5-11H,3-4,13H2,1-2H3,(H,22,23)

Isomères SMILES

CCOP(=O)(CC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)Br)C#N)OCC

WGK Allemagne

3

Poids moléculaire

451.25

Reaxy-Rn

7497256

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7497256&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Anilides
        • Level5 Aromatic anilides
          • Level6 Benzanilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Anilides
• Intermediate Tree Nodes: Aromatic anilides
• Direct Parent: Benzanilides
• Alternative Parents: Benzamides Benzoyl derivatives Benzonitriles Dialkyl alkylphosphonates Bromobenzenes Phosphonic acid esters Aryl bromides Secondary carboxylic acid amides Nitriles Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organobromides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzanilide - Benzamide - Benzoic acid or derivatives - Benzonitrile - Benzoyl - Dialkyl alkylphosphonate - Bromobenzene - Halobenzene - Phosphonic acid diester - Phosphonic acid ester - Aryl bromide - Aryl halide - Organophosphonic acid derivative - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Nitrile - Carbonitrile - Hydrocarbon derivative - Organohalogen compound - Organobromide - Organonitrogen compound - Organooxygen compound - Organopnictogen compound - Organic oxygen compound - Organophosphorus compound - Organic nitrogen compound - Organic oxide - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

LPL Tchem Lipoprotein lipase (101 Activities)

Discover Target: LPL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPTEC (172 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in DMSO (≥20 mg/ml).
• Indice de réfraction: n20D1.59 (Predicted)
• Point d'ébullition (°C): 512.47° C at 760 mmHg (Predicted)
• Point de fusion (°C): 90.27° C (Predicted)
• Poids moléculaire: 451.200 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 450.034 Da
• Monoisotopic Mass: 450.034 Da
• Topological Polar Surface Area: 88.400 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 576.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1