Icaritin - ≥98%(HPLC) , CAS No.118525-40-9

CAS: 118525-40-9 Cat. No.: I137443 Molecular Weight: 368.38
AVAILABLE TO ORDER
GRADE & PURITY ≥98%(HPLC)
Synonyms
Icaritin | 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one | UFE666UELY | CHEMBL498485 | SGN162 | SGN-162 | 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one | Anhydroicaritin | Cycloicaritin
Storage
Store at 2-8°C
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25mg
I137443-25mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$9.90
100mg
I137443-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$29.90
250mg
I137443-250mg
2
$59.90
1g
I137443-1g
1
$199.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Icaritin is a component of Epimedium flavonoid isolated from Herba Epimedii; enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs by inhibiting PPAR-g pathway.

Specifications

Synonyms
Icaritin | 3, 5, 7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one | UFE666UELY | CHEMBL498485 | SGN162 | SGN-162 | 3, 5, 7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one | Anhydroicaritin | Cycloicaritin
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
Icaritin is a component of Epimedium flavonoid isolated from Herba Epimedii, which enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs by inhibiting PPAR-g pathway. Icaritin has no ef
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%(HPLC)
Names and Identifiers
Pubchem Sid504763584
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504763584
Canonical SmilesCC(=CCC1=C2C(=C(C=C1O)O)C(=O)C(=C(O2)C3=CC=C(C=C3)OC)O)C
IUPAC Name3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one
InChIKeyTUUXBSASAQJECY-UHFFFAOYSA-N
INCHI1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3
Isomeric SMILES CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C(=C(O2)C3=CC=C(C=C3)OC)O)C
WGK Germany 3
Molecular Weight 368.38
Reaxy-Rn 347627
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=347627&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassFlavonoids
SubclassFlavones
Intermediate Tree Nodes Not available
Direct Parent8-prenylated flavones
Alternative Parents 4'-O-methylated flavonoids  Flavonols  3-hydroxyflavonoids  5-hydroxyflavonoids  7-hydroxyflavonoids  Chromones  Phenoxy compounds  Methoxybenzenes  Anisoles  1-hydroxy-2-unsubstituted benzenoids  Pyranones and derivatives  Alkyl aryl ethers  Vinylogous acids  Heteroaromatic compounds  Oxacyclic compounds  Polyols  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents 8-prenylated flavone - 4p-methoxyflavonoid-skeleton - 3-hydroxyflavone - 3-hydroxyflavonoid - 5-hydroxyflavonoid - 7-hydroxyflavonoid - Hydroxyflavonoid - Chromone - Benzopyran - 1-benzopyran - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Pyranone - Phenol - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Pyran - Monocyclic benzene moiety - Vinylogous acid - Heteroaromatic compound - Oxacycle - Organoheterocyclic compound - Polyol - Ether - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Organic oxide - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as 8-prenylated flavones. These are flavones that features a C5-isoprenoid substituent at the 8-position.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMMC-7721 (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hep 3B2 (2332 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
PDE6C Phosphodiesterase 6C (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus cereus (7522 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

36 results found

Lot NumberCertificate TypeDateItem
D2630340Certificate of AnalysisApr 16, 2026 I137443
D2630338Certificate of AnalysisApr 16, 2026 I137443
D2630336Certificate of AnalysisApr 16, 2026 I137443
D2630337Certificate of AnalysisApr 16, 2026 I137443
B2428259Certificate of AnalysisDec 12, 2025 I137443
B2428261Certificate of AnalysisDec 12, 2025 I137443
L2508077Certificate of AnalysisOct 13, 2025 I137443
J2527637Certificate of AnalysisOct 13, 2025 I137443
J2527636Certificate of AnalysisOct 13, 2025 I137443
J2527635Certificate of AnalysisOct 13, 2025 I137443
J2527634Certificate of AnalysisOct 13, 2025 I137443
B2624236Certificate of AnalysisOct 13, 2025 I137443
E2521369Certificate of AnalysisApr 29, 2025 I137443
E2521378Certificate of AnalysisApr 29, 2025 I137443
E2521428Certificate of AnalysisApr 29, 2025 I137443
E2521429Certificate of AnalysisApr 29, 2025 I137443
G2522040Certificate of AnalysisApr 29, 2025 I137443
A2309777Certificate of AnalysisOct 24, 2024 I137443
A2309800Certificate of AnalysisOct 24, 2024 I137443
A2309801Certificate of AnalysisOct 24, 2024 I137443
A2309778Certificate of AnalysisOct 17, 2024 I137443
J2415820Certificate of AnalysisSep 23, 2024 I137443
J2415821Certificate of AnalysisSep 23, 2024 I137443
J2415822Certificate of AnalysisSep 23, 2024 I137443
G2408507Certificate of AnalysisJun 13, 2024 I137443
G2408509Certificate of AnalysisJun 13, 2024 I137443
G2408517Certificate of AnalysisJun 13, 2024 I137443
B2428297Certificate of AnalysisJan 31, 2024 I137443
B2428260Certificate of AnalysisJan 31, 2024 I137443
B2427605Certificate of AnalysisJul 25, 2023 I137443
G2321733Certificate of AnalysisJul 25, 2023 I137443
G2321947Certificate of AnalysisJul 25, 2023 I137443
A2309826Certificate of AnalysisDec 30, 2022 I137443
A2309750Certificate of AnalysisDec 30, 2022 I137443
E1705116Certificate of AnalysisDec 08, 2022 I137443
L2015152Certificate of AnalysisOct 15, 2022 I137443

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Chemical and Physical Properties
SensitivityHeat Sensitive
Melt Point(°C)233°C
Molecular Weight368.400 g/mol
XLogP34.800
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass368.126 Da
Monoisotopic Mass368.126 Da
Topological Polar Surface Area96.200 Ų
Heavy Atom Count27
Formal Charge0
Complexity612.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Kaijia Zhang, Jian Dong, Jun Lu, Lan Li, Huan Liang, Jing Jin, Peng Wang, Xiaolian Sun, Qing Jiang.  (2022)  Icaritin-Incorporated Porous Hollow Iron Oxide Nanostructures for Promoting Fracture Repair.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.2c00660]
2. Song Wang, Xinnan Chang, Jing Li, Zuoqiao Shi, Guowen Li.  (2025)  Identification of chemical components and metabolites in rats after oral administration of Epimedium-Astragalus granule pair by liquid chromatography-high resolution mass spectrometry combined with diagnostic fragment ions and mass defect filtering.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:40014893] [10.1016/j.jpba.2025.116768]
3. Jiaojiao Ding, Tiexiang Gao, Songlin Liu, Zhezhe Li, Baifei Hu, Junping Zhen, Xiaowei Yao, Hongtao Liu, Haiming Hu.  (2025)  Rhamnosidase from Parabacteroides distasonis exhibit the catabolism of epimedin C in the human gut microbiota.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40157660] [10.1016/j.ijbiomac.2025.142481]
4. Jiali Tang, Yanlu Chen, Hao Lai, Qi Zeng, Yu Li, Junqi Feng, Ningjing Lin, Ronghua Jin, Junjie Liu, Tao Luo, Zixuan Liang.  (2025)  Innovative immunosonogen nanoplatform combining sonodynamic oxygenation and immunomodulation for superior cancer therapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.163582]
5. Anyi Wu, Junping Zhou, Yinan Xue, Yun Liu, Jidong Shen, Xin Gao, Zhiqiang Liu, Yuguo Zheng.  (2025)  Efficient multi-enzyme system for icaritin production from naringenin with synchronous prenol utilization in Escherichia coli.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41314575] [10.1016/j.ijbiomac.2025.149283]
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