L-Carnosine - Moligand™, ≥98% , CAS No.305-84-0

CAS: 305-84-0 Cat. No.: C106843 Formule: C₉H₁₄N₄O₃ Poids moléculaire: 226.23 Beilstein Registry Number: 87671 Numéro CE: 206-169-9

GRADE & PURITY Moligand™, ≥98%

Synonyms

bêta-alanyl-L-histidine | H-bêta-Ala-His-OH | L-gnotine | β-alanyl-L-histidine

Storage

Stocker à -20°C, chargé d'argon

Shipped In

Glacière + blocs de glace

Vue d’ensemble

La carnosine est un antioxydant. Elle inhibe la guanylyl cyclase soluble (sGC) en interagissant avec le fer héminique pour former un complexe chélaté.
Inhibiteur antioxydant de la guanylyl cyclase soluble.

Specifications

Synonymes

bêta-alanyl-L-histidine | H-bêta-Ala-His-OH | L-gnotine | β-alanyl-L-histidine

Spécifications et pureté

Moligand™, ≥98%

Mécanismes biochimiques et physiologiques

La L-Carosine est un dipeptide que l'on trouve à des concentrations millimolaires dans le cerveau, les muscles et le cristallin. Dans les systèmes modèles, c'est un antioxydant puissant qui élimine les radicaux libres de l'oxygène et les ions des métaux d

Conditions de stockage de stockage

Stocker à -20°C, chargé d'argon

Expédié en

Glacière + blocs de glace

Grade

Moligand™

Pureté

≥98%

Noms et identifiants

Pubchem Sid

528765217

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/528765217

Sourires canoniques

C1=C(NC=N1)CC(C(=O)O)NC(=O)CCN

IUPAC Name

(2S)-2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid

InChIKey

CQOVPNPJLQNMDC-ZETCQYMHSA-N

INCHI

1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1

Isomères SMILES

C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)CCN

WGK Allemagne

2

RTECS

MS3080000

CAS alternatif

305-84-0,1370422-07-3

Termes d'entrée MeSH

beta Alanylhistidine;beta-Alanylhistidine;Carnosine;Carnosine Hydrochloride;Carnosine, (D-His)-Isomer;Hydrochloride, Carnosine;L Carnosine;L-Carnosine

Poids moléculaire

226.23

Beilstein

87671

Reaxy-Rn

535203

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=535203&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Peptidomimetics
      • Subclass Hybrid peptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Peptidomimetics
• Subclass: Hybrid peptides
• Intermediate Tree Nodes: Not available
• Direct Parent: Hybrid peptides
• Alternative Parents: Histidine and derivatives N-acyl-L-alpha-amino acids Beta amino acids and derivatives Imidazolyl carboxylic acids and derivatives Heteroaromatic compounds Secondary carboxylic acid amides Amino acids Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Hybrid peptide - Histidine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-acyl-l-alpha-amino acid - Beta amino acid or derivatives - Alpha-amino acid or derivatives - Imidazolyl carboxylic acid derivative - Azole - Heteroaromatic compound - Imidazole - Amino acid - Amino acid or derivatives - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organopnictogen compound - Primary aliphatic amine - Organic nitrogen compound - Amine - Organonitrogen compound - Organooxygen compound - Carbonyl group - Primary amine - Hydrocarbon derivative - Organic oxygen compound - Organic oxide - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
• External Descriptors: dipeptide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in 80% acetic acid (10 mg/ml), and water (1:3.1).
• Sensibilité: Hygroscopic;air sensitive
• Rotation spécifique [α]: 21 ° (C=2, H2O)
• Point de fusion (°C): 253°C
• Poids moléculaire: 226.230 g/mol
• XLogP3: -4.000
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 226.107 Da
• Monoisotopic Mass: 226.107 Da
• Topological Polar Surface Area: 121.000 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 259.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1