Leupeptin - EnzymoPure™, 10mM in DMSO , CAS No.103476-89-7

CAS: 103476-89-7 Cat. No.: L420424 Formule: C₂₀H₃₈N₆O₄·1/2(H₂SO₄) Poids moléculaire: 475.59 Numéro CE: 600-443-5 PubChem CID: 2733491

GRADE & PURITY EnzymoPure™, 10mM in DMSO

Synonyms

Leupeptin hemisulfate|103476-89-7|Leupeptin hemisulfate anhydrous|UNII-05V9Y5208M|05V9Y5208M|L-Leucinamide, N-acetyl-L-leucyl-N-((1S)-4-((aminoiminomethyl)amino)-1-formylbutyl)-, sulfate (2:1)|Leupeptin hemisulfate salt|(2S)-2-acetamido-N-[(2S)-1-[[(2S)-5

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

A reversible inhibitor of cysteine proteases and serine proteases resembling trypsin Reversible inhibitor Ultra pure grade Inhibits trypsin, plasmin, papain, kallikrein, thrombin and cathepsin A and B.

Specifications

Synonymes

Leupeptin hemisulfate | 103476-89-7 | Leupeptin hemisulfate anhydrous | UNII-05V9Y5208M | 05V9Y5208M | L-Leucinamide, N-acetyl-L-leucyl-N-((1S)-4-((aminoiminomethyl)amino)-1-formylbutyl)-, sulfate (2:1) | Leupeptin hemisulfate salt | (2S)-2-acetamido-N-[(2S)-1-[[(2S)-5

Spécifications et pureté

EnzymoPure™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

Reversible, competitive serine/cysteine protease inhibitor. Inhibits cathepsins B, H, L and S, calpain and trypsin. Orally active. Antioxidant and anti-inflammatory agent. Active in vivo and in vitro .

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

EnzymoPure™

Type d'action

INHIBITOR

Noms et identifiants

Pubchem Sid

528769873

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/528769873

Sourires canoniques

CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O

IUPAC Name

(2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide;sulfuric acid

InChIKey

CIPMKIHUGVGQTG-VFFZMTJFSA-N

INCHI

1S/2C20H38N6O4.H2O4S/c2*1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;1-5(2,3)4/h2*11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H2,1,2,3,4)/t2*15-,16-,17-;/m00./s1

Isomères SMILES

CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)C.CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O

PubChem CID

2733491

Poids moléculaire

475.59

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Dipeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Dipeptides
• Alternative Parents: Leucine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Organic sulfuric acids N-acyl amines Acetamides Secondary carboxylic acid amides Guanidines Propargyl-type 1,3-dipolar organic compounds Carboximidamides Organopnictogen compounds Organic oxides Hydrocarbon derivatives Aldehydes
• Molecular Framework: Not available
• Substituents: Alpha-dipeptide - Leucine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Sulfuric acid - Fatty amide - Fatty acyl - N-acyl-amine - Acetamide - Organic sulfuric acid or derivatives - Carboxamide group - Guanidine - Secondary carboxylic acid amide - Carboximidamide - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Aldehyde - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mécanismes d'action

Propriétés chimiques et physiques

• Poids moléculaire: 951.200 g/mol
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 28
• Exact Mass: 950.558 Da
• Monoisotopic Mass: 950.558 Da
• Topological Polar Surface Area: 421.000 Ų
• Heavy Atom Count: 65
• Formal Charge: 0
• Complexity: 683.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 6
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3