LGD-6972 - Moligand™, 10mM in DMSO , CAS No.1207989-09-0

CAS: 1207989-09-0 Cat. No.: L655135 Formule: C₄₃H₄₆N₂O₅S Poids moléculaire: 702.90 PubChem CID: 44625560

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

LGD-6972 is a selective and orally active Glukagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.

In Vitro

In vitro, LGD-6972 binds competitively to Glukagon receptor (GCGR) with high affinity and selectivity, suppressing both cAMP and glucose production. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo, LGD-6972 reduces acute Glukagon-stimulated hyperglycaemia as well as the hyperglycaemia observed in diabetic mouse models. The pharmacological activity of LGD-6972 appears to be mediated primarily by inhibiting Glukagon receptor signaling . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Spécifications et pureté

Moligand™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

LGD-6972 is a selective and orally active Glukagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Noms et identifiants

• Isomères SMILES: CC1=CC(=C(C(=C1)C)C2=CC=C(C=C2)NC(=O)[C@H](CC3=CC=C(C=C3)C(=O)NCCS(=O)(=O)O)C4=CC=C(C=C4)C5=CC=C(C=C5)C(C)(C)C)C
• CAS alternatif: 1207989-09-0
• PubChem CID: 44625560
• Termes d'entrée MeSH: 2-((4-((2R)-2-(4-(4-tert-butylphenyl)phenyl)-3-oxo-3-(4-(2,4,6-trimethylphenyl)anilino)propyl)benzoyl)amino)ethanesulfonic acid;LGD-6972;RVT-1502
• Poids moléculaire: 702.90