Licochalcone A - Moligand™,≥96% , CAS No.58749-22-7

Name: Licochalcone A - Moligand™,≥96% , CAS No.58749-22-7
SKU: L139040
Availability: InStock

CAS: 58749-22-7 Cat. No.: L139040 Formule: C₂₁H₂₂O₄ Poids moléculaire: 338.4 Numéro CE: 635-678-2

3 Citations COA

Skip to the end of the images gallery

Licochalcone A - Moligand™,≥96% CAS No(58749-22-7) by Aladdin Scientific

Skip to the beginning of the images gallery

DISPONIBLE À COMMANDE

GRADE & PURITY Moligand™ ? ≥96%

Synonyms

Storage

Stocker à -20°C, chargé d'argon

Shipped In

Glacière + blocs de glace

Vue d’ensemble Specifications Noms et identifiants Documentation Advanced Data Taxonomic Classification Structure 3D Cibles associées (humaines) Cibles associées (non humaines) Mécanismes d'action Certificats (CoA, COO, BSE/TSE et tableau d'analyse) Propriétés chimiques et physiques Citations of This Product Calculateurs de solution Avis Foire aux questions

🧪

Why this grade

Moligand™,≥96% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Stocker à -20°C, chargé d'argon Ships Glacière + blocs de glace Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Vue d’ensemble

La licochalcone A, synthétique, est un flavanoïde œstrogène dérivé à l'origine de la racine de réglisse (Glycyrrhiza glabra). La Licochalcone-A a démontré sa capacité à réduire l'expression de la protéine Bcl-2 et à induire l'apoptose dans plusieurs lignées cellulaires cancéreuses humaines. La licochalcone-A induit également la différenciation cellulaire et présente une activité antibactérienne, anti-inflammatoire et antitumorale. Il a été signalé qu'elle interférait avec la chaîne de transport d'électrons et le métabolisme énergétique des mitochondries parasitaires et qu'elle inhibait également la croissance in vitro du parasite du paludisme humain Plasmodium falciparum. Il existe également des preuves que la licochalcone-A peut réguler la prolifération des cellules musculaires lisses vasculaires chez le rat.

Specifications

Synonymes

Spécifications et pureté

Moligand™,≥96%

Conditions de stockage de stockage

Stocker à -20°C, chargé d'argon

Expédié en

Glacière + blocs de glace

Grade

Moligand™

Pureté

≥96%

Noms et identifiants

Pubchem Sid

504763586

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504763586

Sourires canoniques

CC(C)(C=C)C1=C(C=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)O)OC)O

IUPAC Name

(E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one

InChIKey

KAZSKMJFUPEHHW-DHZHZOJOSA-N

INCHI

1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+

Isomères SMILES

CC(C)(C=C)C1=C(C=C(C(=C1)/C=C/C(=O)C2=CC=C(C=C2)O)OC)O

Poids moléculaire

338.4

Reaxy-Rn

26898492

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26898492&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Classe Linear 1,3-diarylpropanoids
    - Subclass Chalcones and dihydrochalcones

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Classe	Linear 1,3-diarylpropanoids
Subclass	Chalcones and dihydrochalcones
Intermediate Tree Nodes	Not available
Direct Parent	Retrochalcones
Alternative Parents	Cinnamylphenols Hydroxycinnamic acids and derivatives Methoxyphenols Phenylpropanes Styrenes Phenoxy compounds Methoxybenzenes Benzoyl derivatives Aryl ketones Anisoles 1-hydroxy-2-unsubstituted benzenoids Alkyl aryl ethers Acryloyl compounds Enones Hydrocarbon derivatives Organic oxides
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Retrochalcone - Cinnamylphenol - Hydroxycinnamic acid or derivatives - Methoxyphenol - Phenylpropane - Phenoxy compound - Anisole - Benzoyl - Methoxybenzene - Phenol ether - Aryl ketone - Styrene - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Benzenoid - Enone - Alpha,beta-unsaturated ketone - Acryloyl-group - Ketone - Ether - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as retrochalcones. These are a form of normal chalcones that are structurally distinguished by the lack of oxygen functionalities at the C2'- and C6'-positions.
External Descriptors	Chalcones and dihydrochalcones
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Structure 3D

Cibles associées (humaines)

UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (1 Activities)

Discover Target: UGT1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCG2 Tchem ATP-binding cassette sub-family G member 2 (19 Activities)

Discover Target: ABCG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACE Tclin Angiotensin-converting enzyme (1423 Activities)

Discover Target: ACE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TYR Tclin Tyrosinase (717 Activities)

Discover Target: TYR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)

Discover Target: MMP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HT-1080 (3966 Activities)

Lot Number	Certificate Type	Date	Article
K2212222	Certificate of Analysis	May 11, 2026	L139040
K2212224	Certificate of Analysis	May 11, 2026	L139040
K2212226	Certificate of Analysis	May 11, 2026	L139040
B2603418	Certificate of Analysis	Jan 23, 2026	L139040
B2603446	Certificate of Analysis	Jan 23, 2026	L139040
B2603449	Certificate of Analysis	Jan 23, 2026	L139040
K2110130	Certificate of Analysis	Aug 15, 2023	L139040
K2110124	Certificate of Analysis	Aug 15, 2023	L139040

Solubilité	≥33.8 mg/mL in DMSO; insoluble in H2O; ≥52.5 mg/mL in EtOH
Sensibilité	Air sensitive;Heat sensitive
Poids moléculaire	338.400 g/mol
XLogP3	4.900
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	338.152 Da
Monoisotopic Mass	338.152 Da
Topological Polar Surface Area	66.800 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	488.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Licochalcone A - Moligand™,≥96% , CAS No.58749-22-7

Storage & shipping

Quality documents

Literature proof

Vue d’ensemble

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Avis des clients

Foire aux questions

📚 Citations by Application

Need help choosing the grade?

View related series

Produits apparentés