Magnetic adsorbent - Matrix:SiO2,Surface group:-NH2,Size:4-5um,unit:10mg/ml

Cat. No.: M121914

GRADE & PURITY Matrix:SiO2,Surface group:-NH2,Size:4-5um,unit:10mg/ml

Storage

Room temperature

Shipped In

Normal

Specifications

Spécifications et pureté

Matrix:SiO2,Surface group:-NH2,Size:4-5um,unit:10mg/ml

Conditions de stockage de stockage

Room temperature

Expédié en

Normal

Application Protocols

No tested applications or validated protocols are provided in the Product Data for SKU M121914. The workflow below is a general template for batch adsorption with magnetic recovery and should be adapted to the actual surface chemistry. It is not a substitute for the product IFU or SDS.

Generic batch adsorption workflow (literature/practice)

• Equilibration: Resuspend the magnetic adsorbent; wash 2–3× with working buffer/solvent to exchange the storage medium and remove fines.
• Binding: Combine sample with a measured mass/volume of adsorbent (e.g., 1–20 mg/mL starting point). Mix gently (end-over-end or orbital) for 5–30 min.
• Magnetic capture: Place the vessel on a strong magnet; allow particles to clear (seconds to minutes). Carefully decant or pipette the supernatant.
• Wash: Add fresh buffer/solvent; resuspend and capture; repeat 1–3×. Adjust stringency (salt/solvent) to balance recovery and purity.
• Elution/regeneration: Desorb the target with appropriate eluent (pH shift, salt, chelator, organic modifier, or competitive ligand). Collect eluate. For reuse, wash until neutral and store as recommended.

Tips

• Pre-determine the adsorbent capacity and optimal contact time using small-scale screens.
• Avoid overdrying beads; keep as a slurry when possible to minimize dust and aggregation.
• Validate absence of bead carryover by microscopic inspection or iron assay when needed.

For SKU M121914, any product-specific instructions (e.g., storage medium, preservatives, recommended buffers) are Not specified for this item; refer to CoA/Spec Sheet.

Biological Roles

Item-specific biological properties are not provided for this product. As a materials class, magnetic adsorbents are engineered tools rather than biomolecules and do not possess intrinsic biological roles in vivo.

General context (literature/practice)

• Functional purpose: provide magnetically retrievable surfaces for selective adsorption of biomolecules (nucleic acids, proteins, glycans, metabolites) via ion exchange, hydrophobic, affinity, or chelation interactions.
• Common bio-workflows: DNA/RNA cleanup and size selection, phosphopeptide enrichment for proteomics, immunocapture when conjugated to antibodies/aptamers, endotoxin or host-cell protein reduction during process development.
• Surface chemistry dictates selectivity: carboxylated beads favor nucleic acid binding in PEG/salt; IMAC-type surfaces (e.g., Ni2+/NTA on magnetic carriers) capture His-tagged proteins; TiO2-modified magnetic particles enrich phosphorylated species by Lewis acid–base interactions.
• Biocompatibility: many iron oxide–based cores are considered chemically inert under neutral aqueous conditions; bioburden/endotoxin levels and extractables depend on manufacturing controls.

Caveats

• For cell-based or diagnostic applications, sterility, endotoxin, and leachables specifications are critical. These are Not specified for this item; refer to CoA/Spec Sheet.
• No medical, clinical, or in vivo claims are made for SKU M121914. It is supplied strictly for research use only (per Product Data).

Buffer Applications

Magnetic adsorbents are routinely used in buffered systems; however, the optimal buffer composition depends on the surface functionality, which is not provided for SKU M121914.

General buffer guidance (literature/practice)

• Equilibration: match the buffer pH/ionic strength to the intended adsorption mechanism (e.g., low ionic strength near opposite-charge conditions for ion exchange; high salt for hydrophobic interactions to promote salting-out).
• Common buffers: Tris, HEPES, phosphate, acetate, and MES across pH ~4–9 for biomolecule workflows. Maintain buffer components that do not chelate metals unless using a metal-affinity mechanism (avoid EDTA with IMAC unless eluting).
• Nucleic acid workflows: binding promoted by PEG or isopropanol/ethanol with high salt (NaCl/NaOAc), followed by low-salt aqueous elution.
• Protein workflows: adjust pH around protein pI for ion exchange; add imidazole gradients for His-tag IMAC elution when applicable.
• Regeneration: harsh washes (high salt, chaotropes, organic modifiers, pH extremes) may strip foulants but can degrade coatings; confirm compatibility.

Practical tips

• Filter buffers (0.22–0.45 µm) to minimize fouling; degas if bubble entrapment affects mixing.
• Monitor pH drift due to adsorption of buffer components; re-equilibrate as needed.

For SKU M121914, specific buffer recipes, pH limits, and capacity data are Not specified for this item; refer to CoA/Spec Sheet.

Green Alternatives

Magnetic adsorbents can contribute to greener workflows by simplifying solid–liquid separations and reducing energy-intensive steps. The comparison below is general and not item-specific.

Environmental and operational considerations (general)

• Separation efficiency: magnetic capture eliminates vacuum filtration/centrifugation, lowering energy use and consumables (filters, centrifuge tubes) and reducing sample loss.
• Solvent minimization: rapid phase separation enables shorter wash cycles and less solvent for resin transfers.
• Reusability: many magnetic adsorbents can be regenerated, decreasing solid waste relative to single-use filtration media; durability depends on coating chemistry.
• Safety: avoids pressurized equipment for phase separation; however, nanopowders may pose inhalation risks—prefer slurry formats to minimize dust.

Comparison (literature-based, illustrative)

• Magnetic adsorbent vs. conventional activated carbon:
  • Pros: magnet-enabled recovery in turbid/viscous matrices; potential for lower pressure drop; easy batch operation.
  • Cons: lower thermal stability for polymer-coated beads; possible iron or ligand leaching if not properly stabilized.
• Magnetic adsorbent vs. centrifugation-only clarification:
  • Pros: does not require high g-forces; compatible with micro- to meso-scale; reduced equipment footprint.
  • Cons: requires magnets and careful handling to avoid bead carryover.
• Magnetic adsorbent vs. packed-bed chromatography:
  • Pros: simpler setup, scalable in batch mode, tolerant to particulates; fewer cleaning-in-place steps.
  • Cons: less sharp separations, typically lower dynamic binding capacity per volume.

For SKU M121914, regeneration protocols, recyclability, and leaching profiles are Not specified for this item; refer to CoA/Spec Sheet.

Pharmaceutical Uses

No therapeutic or clinical claims are made for this product. The information below addresses potential roles in pharmaceutical research/manufacturing contexts in general and is not specific to SKU M121914.

General formulation/manufacturing roles (literature/practice)

• Process development aids: magnetic adsorbents can be used for rapid screening of binding/elution conditions for downstream purification, enabling high-throughput scouting without columns.
• Impurity scavenging: removal of trace metals (e.g., Pd, Pt, Cu) from drug-substance intermediates using chelating functionalities immobilized on magnetic carriers.
• Bioprocessing R&D: capture/release of recombinant proteins or DNA during method development; host-cell protein or endotoxin reduction using functionalized surfaces.
• Analytical sample prep: cleanup of biological matrices prior to LC–MS (protein precipitation followed by magnetic sorbent cleanup) to reduce matrix effects.

Regulatory/status considerations

• Pharmacopeial monographs typically do not exist for heterogeneous “magnetic adsorbents”; qualification relies on vendor CoA, extractables/leachables studies, and process-specific risk assessments.
• For GMP use, requirements may include trace metal limits, bioburden/endotoxin controls, particulate specifications, and documentation of ligand leaching.

For SKU M121914, grade/purity, extractables, and bioburden/endotoxin status are Not specified for this item; refer to CoA/Spec Sheet. Use is restricted to research applications per Product Data.

Physical Properties

Item-specific physico-chemical data are not provided. Do not construe the values below as specifications for SKU M121914.

Item-specific facts (from Product Data)

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Grade/purity: Not specified for this item; refer to CoA/Spec Sheet.

General/literature values for magnetic adsorbents (illustrative ranges)

• Physical state: typically solid nanoparticles/microparticles supplied dry or as an aqueous slurry (literature).
• Magnetization: superparamagnetic iron oxide cores often exhibit saturation magnetization Ms ~30–80 emu/g (for Fe3O4 cores; depends strongly on core size and coating; literature).
• Particle size: common ranges 20 nm – 2 µm (DLS or SEM/TEM); polydispersity depends on synthesis (literature).
• Density: bulk apparent density varies widely; true density of magnetite ~5.2 g/cm³; silica shell ~2.0 g/cm³; polymer shells ~1.0–1.2 g/cm³ (literature).
• Surface area: 10–200 m²/g depending on porosity and size (BET; literature).
• Isoelectric point (IEP): iron oxide cores IEP ~6–8; surface chemistry can shift IEP across pH ~3–10 (literature).
• Solubility: insoluble solid; dispersible in water or organic media depending on surface functionalization and any stabilizers (literature).
• Thermal behavior: coatings may degrade <250–400 °C; iron oxides stable to >500 °C in inert/oxidizing atmospheres (literature).

Notes for practitioners

• Verify slurry concentration (wt% or mg/mL), particle size distribution, and magnetization for process calculations. For SKU M121914, these parameters are Not specified for this item; refer to CoA/Spec Sheet.

Quality and Grades

Item-specific quality grade and purity are not provided in the Product Data for SKU M121914.

Item-specific facts (from Product Data)

• Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.

How to interpret grades for magnetic adsorbents (general guidance)

• Research grade: suitable for method development and routine laboratory separations; may have broader particle-size distributions and less rigorous extractables/leachables limits.
• Chromatography/bioprocess grade: tighter control of bead size, ligand density, endotoxin/bioburden, and leachables; designed for reproducible adsorption isotherms and scale-up.
• High-purity or electronic grade: minimized trace metal contaminants and organics; relevant for catalysis or microelectronics wet processes.

Quality attributes commonly reported (seek on CoA/Spec Sheet)

• Particle size distribution (D50/D90), polydispersity index.
• Magnetic properties (Ms, remanence, coercivity) and capture time under defined magnets.
• Surface functionality: loading/capacity (e.g., mmol functional group per g, ion-exchange capacity, chelator density).
• Leachable iron or ligand content, ash content, and residual solvents/surfactants.
• Moisture content for dry powders; solids content for slurries.
• Microbiological status (bioburden/endotoxin) for bioprocess applications.

Stabilizers and format

• Some products are supplied as aqueous slurries with preservatives (e.g., low % ethanol or biocides). For this item, the presence/identity of any stabilizers is Not specified for this item; refer to CoA/Spec Sheet.

Recommendation

• Prior to critical use, request the CoA/Spec Sheet for SKU M121914 to confirm capacity, size, and magnetic capture specifications relevant to your workflow.

Reaction and Applications

This product class is widely used as a separations material and as a support/scavenger in chemical workflows. Because item-specific surface chemistry is not provided, the use cases below are general (literature/practice) and should be validated for SKU M121914.

Typical application families (general)

• Adsorptive separations: removal/enrichment of metal ions (e.g., Fe-binding chelators, iminodiacetate), dyes, PFAS surrogates, phenols, and other organics by ion exchange, H-bonding, hydrophobic, or π–π interactions.
• Biomolecule handling: magnetic capture of nucleic acids (carboxylated beads with PEG/NaCl binding), proteins/peptides (ion exchange, IMAC, heparin), phosphopeptide enrichment (TiO2/Fe3O4@TiO2 hybrids), and endotoxin reduction.
• Synthetic chemistry: scavenging residual catalysts (Pd, Ru, Cu) and reagents (isocyanates, anhydrides, acids/bases) post-reaction; supported catalysis (e.g., Pd on magnetic carbon/silica) enabling easy recovery by magnet.
• Environmental testing: batch adsorption studies (isotherms/kinetics) and SPE-like cleanup with magnetic separation.

Practical considerations

• Precondition the adsorbent to the target medium (pH, ionic strength, solvent). Equilibrate to achieve reproducible capacity.
• Kinetics: small magnetic particles often reach equilibrium in 1–60 min depending on diffusion and ligand density. Gentle end-over-end or orbital mixing improves mass transfer.
• Magnetic recovery: use sufficiently strong neodymium magnets; minimize bed compaction by intermittent resuspension if multiple wash cycles are needed.
• Regeneration: elute with competing ligands, pH/salt shifts, or suitable solvents; evaluate capacity retention across cycles.

For SKU M121914, specific adsorption capacities, ligand identity, and optimal operating ranges are Not specified for this item; refer to CoA/Spec Sheet.

Reaction Conditions

Without item-specific surface chemistry, only general operating envelopes can be offered. Treat the following as literature/practice guidance to plan small-scale scouting before scale-up.

General operating parameters (illustrative)

• Solid–liquid ratio: 1–50 mg sorbent per mL solution, depending on capacity and target concentration.
• Contact time: 5–60 min with end-over-end rotation, vortexing, or orbital shaking; finer particles equilibrate more rapidly.
• Temperature: ambient (20–25 °C) is common; elevated temperatures may accelerate kinetics but risk coating degradation.
• pH: optimize per mechanism (e.g., ion exchange effective when analyte and surface have opposite charge; chelation often favors neutral to slightly basic); avoid pH extremes unless validated.
• Ionic strength: can suppress electrostatic adsorption; adjust salt for selectivity.
• Magnets: neodymium bar or ring magnets positioned externally; typical capture in seconds to a few minutes depending on bead size and viscosity.

Validation and analytics

• Measure residual target by HPLC/GC/UV/ICP as appropriate; construct adsorption isotherms (Langmuir/Freundlich) to size the process.
• Assess reusability by cycling (adsorb–elute–wash) and monitoring capacity loss.

Cautions

• Strong oxidants/reductants and chelators can alter the iron oxide core or strip ligands; test compatibility.
• Viscous or high-solid matrices may require longer capture times or stepwise addition to avoid clumping.

For SKU M121914, definitive operating ranges and capacities are Not specified for this item; refer to CoA/Spec Sheet.

Safety and Handling

Authoritative safety information must be taken from the product SDS. The following summarizes general considerations for magnetic adsorbent materials.

Item-specific hazard data (from Product Data)

• Signal word: Not specified for this item; refer to SDS.
• H-statements and GHS classification/pictograms: Not specified for this item; refer to SDS.

General safety guidance (literature/practice)

• Likely hazards: nuisance dust (inhalation), eye/skin irritation from fine particulates or functional groups; combustible dust risk for some organic-coated powders; environmental persistence if released in bulk. If surface groups are corrosive/caustic (e.g., strong cation/anion exchangers), additional hazards may apply.
• PPE: safety glasses or goggles, lab coat, disposable nitrile gloves. Use a dust mask/respirator if generating aerosols or handling dry, fine powders. Work in a fume hood or at least a well-ventilated area for powders or volatile dispersants.
• Handling cautions:
  • Keep away from strong magnets/electromagnets on benches and instruments to prevent unintended particle movement and fouling.
  • Avoid contact with strong oxidizers or strong acids/bases unless the surface chemistry is designed for such conditions; acidic dissolution can release dissolved iron.
  • Prevent dust formation; antistatic measures for dry polymer-coated particles.
• First aid (overview, consult SDS): flush eyes/skin with water for several minutes; remove to fresh air after inhalation; if ingested, rinse mouth; seek medical attention as appropriate.
• Spill response: contain with damp disposable towels or HEPA vacuum; avoid spreading fine particles. Collect using a magnet when appropriate, then transfer to waste container.
• Waste disposal: follow local regulations; many labs treat spent magnetic adsorbents as solid chemical waste. Regeneration/elution streams may contain adsorbates requiring specialized disposal.

Solvent Selection

Item-specific solvent compatibility is not provided. The guidance below reflects general behavior of magnetic adsorbents.

General solvent/matrix compatibility (literature)

• Aqueous systems: hydrophilic/silica- or polymer-coated magnetic adsorbents commonly disperse well in water and buffered saline across a moderate pH range (e.g., pH 3–10), enabling biomolecule capture, metal scavenging, or dye adsorption.
• Organic systems: organophilic coatings (e.g., alkyl, polystyrene, carbon) allow dispersion in alcohols, ketones, esters, aromatics, and some chlorinated solvents; swelling and stability depend on the shell polymer.
• Mixed solvents: water–alcohol or water–acetonitrile blends are frequently used to tune adsorption and viscosity.

Polarity and dielectric considerations

• Magnetic cores are inorganic; dispersion is governed by the shell’s surface energy/charge. Choose solvent systems that maintain colloidal stability (zeta potential magnitude > |25–30| mV is a rough target in DLS measurements; literature) and preserve ligand integrity.

When to choose a magnetic adsorbent vs alternatives

• Choose magnetic adsorbents when rapid, equipment-light solid–liquid separations are desired, especially with viscous or particulate-laden matrices where filtration/centrifugation is inefficient.
• Consider conventional adsorbents (activated carbon, silica, polymer resins) when high-temperature regeneration or high-pressure packed-bed operation is required.

Practical tips

• Pre-wet and equilibrate beads in the working solvent/buffer to avoid aggregation and to exchange storage medium.
• For unknown compatibility, conduct a small-scale screening: 10–30 min gentle mixing in candidate solvents, then assess recovery with a bench magnet and inspect for leaching, swelling, or loss of magnetism.

For SKU M121914, solvent recommendations specific to the supplied surface chemistry are Not specified for this item; refer to CoA/Spec Sheet.

Storage and Reconstitution

Item-specific storage and reconstitution details are limited in the Product Data.

Item-specific facts (from Product Data)

• Storage conditions: Room temperature.
• Shipped: Normal.
• Appearance, formulation (dry vs slurry), and stabilizers/preservatives: Not specified for this item; refer to CoA/Spec Sheet.

General guidance (literature/practice)

• If supplied as a dry powder: store tightly sealed in a cool, dry place away from strong magnetic fields and moisture. Minimize mechanical shock to limit fines formation. To reconstitute, wet with a miscible solvent (e.g., ethanol or buffer) then dilute into the working medium with gentle agitation; sonication (brief, low-power) can help disperse aggregates.
• If supplied as an aqueous slurry: store upright to minimize valve clogging; gently invert/roll to homogenize before use. Avoid freezing unless specified by the manufacturer, as freeze–thaw can crack coatings and change dispersion behavior.
• Preservation: some slurries contain biocides or low % alcohol; verify compatibility with your application and remove by washing before sensitive assays if necessary.
• Shelf life: monitor performance (capacity, capture time) over time; discard if excessive leaching, rust coloration, or aggregation is observed.

Always defer to the product’s label and CoA/Spec Sheet for definitive storage, reconstitution, and use instructions specific to SKU M121914.

Structure and Identity

Item-specific identifiers and composition for this product are not provided in the Product Data. Where a specific value is needed, we state: Not specified for this item; refer to CoA/Spec Sheet.

Item-specific facts (from Product Data)

• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES/InChIKey/CAS/CID: Not specified for this item; refer to CoA/Spec Sheet.
• Storage conditions: Room temperature (per Product Data)
• Shipped in: Normal (per Product Data)

General description (literature/typical for “magnetic adsorbent” materials)

• A magnetic adsorbent commonly consists of a superparamagnetic iron oxide core (e.g., Fe3O4 magnetite or γ-Fe2O3 maghemite) enveloped by an inorganic (silica, carbon) or polymeric shell that bears surface functional groups (e.g., –OH, –COOH, –NH2, quaternary ammonium, imidazolium, chelators, or affinity ligands).
• Morphology: typically spherical or quasi-spherical nanoparticles or microparticles; may be aggregated into porous granules or beads. The shell imparts chemical selectivity and colloidal stability; the core enables rapid magnetic capture.
• Structural features (typical):
  • Core: inverse spinel iron oxide lattice responsible for magnetic behavior.
  • Shell: silanol-rich silica, graphitic carbon, or crosslinked polymers (e.g., polystyrene, polyacrylate, dextran) optionally bearing functional moieties for adsorption (ionic, hydrogen-bonding, π–π, or coordinate interactions).
  • No stereocenters (materials are heterogeneous solids). 2D depictions often show an iron oxide core with concentric coating layers and surface functionality icons rather than a discrete molecule.

Important note

• The exact core composition, coating, particle size, and surface functionality for SKU M121914 are Not specified for this item; refer to CoA/Spec Sheet.

Synthetic Utility

While not a reagent in the classical sense, magnetic adsorbents are highly useful tools in synthesis and workup. The points below are general to the class and not specific to SKU M121914.

Utility in synthetic workflows (general)

• Scavenging: post-reaction cleanup of residual metals (Pd, Ru, Cu, Ni), halides, acids/bases, isocyanates, boron species, and thiols using appropriately functionalized magnetic scavengers; magnetic decantation streamlines operations.
• Supported catalysis: immobilization of catalytic species (e.g., Pd, Cu, organocatalysts) on magnetic carriers permits easy separation and reuse, reducing catalyst loss and metal contamination.
• Catch-and-release strategies: temporary capture of intermediates (e.g., carbonyls via hydrazone/oxime linkers; boronic acids via diol interactions) enabling purification or switching solvents.
• Flow-to-batch bridging: magnetic beds can be used in oscillatory baffled reactors or stirred batch units where traditional packed beds would plug.

Practical guidance

• Select surface functionality aligned to the impurity class; for metals, chelators like IDA/NTA/dithiocarbamates are common; for electrophiles, amine/thiol surfaces; for acids, basic resins.
• Quantify capacity by small-scale isotherm tests; typical contact times range from 5–60 min under agitation; verify completeness by ICP-OES or HPLC.
• Validate absence of leaching from the adsorbent into product streams.

For SKU M121914, the specific functional groups, metal uptake capacities, and solvent windows are Not specified for this item; refer to CoA/Spec Sheet.

Target Specificity

This section is typically applicable to affinity reagents such as antibodies or ligand-defined capture media with declared selectivity. For SKU M121914, no item-specific ligand, epitope, or target-binding information is provided.

Item-specific facts (from Product Data)

• Target/ligand identity, species reactivity, clone/isotype: Not specified for this item; refer to CoA/Spec Sheet.

General note

• Magnetic adsorbents can be engineered for specificity via immobilized ligands (e.g., chelators for metals, antibodies/aptamers for proteins, ion-exchange groups for charge-based selectivity). In the absence of such declarations, treat the material as a general adsorbent and empirically determine selectivity.