Memantine HCl - 10mM in DMSO , Glutamate [NMDA] receptor negative allosteric modulator, CAS No.41100-52-1, Glutamate [NMDA] receptor negative allosteric modulator

CAS: 41100-52-1 Cat. No.: M409221 Formule: C₁₂H₂₁N·HCl Poids moléculaire: 215.76 Numéro CE: 255-219-6

GRADE & PURITY 10mM in DMSO

Synonyms

3,​5-​dimethyl-​tricyclo[3.3.1.13,​7]​decan-​1-​amine,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

Memantine HCl Memantine HCl is an antagonist of NMDAR . It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥100%

Specifications

Synonymes

3,​5-​dimethyl-​tricyclo[3.3.1.13,​7]​decan-​1-​amine,hydrochloride (1:1)

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

NEGATIVE ALLOSTERIC MODULATOR

Mécanisme d'action

Glutamate [NMDA] receptor negative allosteric modulator

Noms et identifiants

• Isomères SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
• WGK Allemagne: 3
• Poids moléculaire: 215.76
• Reaxy-Rn: 6573843
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6573843&ln=

Propriétés chimiques et physiques

• Point de fusion (°C): 292°C

Références

1. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan.  (2023)  Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection.  Biosensors-Basel,  13  (4): (489).  [PMID:37185564] [10.3390/bios13040489]

2. Fangfang Shen, Dingqiang Lu, Xiuquan Ling, Xinxian Wang, Tongqi Liu, Tianhua Huang, Kefei He.  (2016)  Thermodynamic analysis and calculation of solubility of Memantine hydrochloride in ethanol plus (acetonitrile, water, ethyl acetate) binary solvent mixtures.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2016.12.051]

3. Gong Chen, Panyang Gu, Wenfang Wu, Yuan Yin, Liangyu Pan, Shu Huang, Wei Lin, Meichun Deng.  (2024)  SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39476923] [10.1016/j.ijbiomac.2024.136767]