MKC-1 - 10mM in DMSO , Platelet-derived growth factor receptor inhibitor, CAS No.125313-92-0, Platelet-derived growth factor receptor inhibitor

CAS: 125313-92-0 Cat. No.: M655611 Formule: C₂₂H₁₆N₄O₄ Poids moléculaire: 400.39 PubChem CID: 5327686

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family .

In Vivo

MKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins incl

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Mécanisme d'action

Platelet-derived growth factor receptor inhibitor

Propriétés du produit

• ALogP: 2.6

Noms et identifiants

• Isomères SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=C4C=CC(=C5)[N+](=O)[O-])C
• PubChem CID: 5327686
• Poids moléculaire: 400.39